Irritable bowel syndrome: anxiety in gastroenterology

Botha, Claude; Libby, G. W.

doi:10.12968/hmed.2006.67.7.21617

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2009

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“…IBS appears to involve alterations in intestinal motility, visceral hypersensitivity and abnormalities in the brain-gut axis that processes visceral information. Anxiety disorders are higher in IBS patients compared to the general population (Lydiard 2001 ; Botha and Libby 2006 ) and psychosocial distress both exacerbates and is a consequence of IBS (Drossman et al 1999 ). Because there is no physiological marker specific for IBS, outcome measures in clinical trials are based on validated scales of patient reports.…”

Section: Methods: the Parent Quantitative Studymentioning

confidence: 99%

“Maybe I Made Up the Whole Thing”: Placebos and Patients’ Experiences in a Randomized Controlled Trial

Kaptchuk

Shaw

Kerr

et al. 2009

Cult Med Psychiatry

136

120

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Patients in the placebo arms of randomized controlled trials (RCT) often experience positive changes from baseline. While multiple theories concerning such ''placebo effects'' exist, peculiarly, none has been informed by actual interviews of patients undergoing placebo treatment. Here, we report on a qualitative study (n = 27) embedded within a RCT (n = 262) in patients with irritable bowel syndrome. Besides identical placebo acupuncture treatment in the RCT, the qualitative study patients also received an additional set of interviews at the beginning,

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Section: Methods: the Parent Quantitative Studymentioning

confidence: 99%