Irritable Bowel Syndrome, Depression, and Neurodegeneration: A Bidirectional Communication from Gut to Brain

Aziz, Muhammad Nazirul Mubin; Kumar, Jaya; Nawawi, Khairul Najmi Muhammad; Ali, Raja Affendi Raja; Mokhtar, Norfilza Mohd

doi:10.3390/nu13093061

Cited by 67 publications

(49 citation statements)

References 122 publications

(165 reference statements)

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“…The study of the effects of the gut microbiome on behavior and neurobiology, known as the MGBA, began with observations on patients with IBS [30]. IBS is characterized by abdominal pain and changes in bowel habits.…”

Section: Discussionmentioning

confidence: 99%

Bibliometric and Visual Analysis of Research on the Links between the Microbiome-Gut-Brain axis and Depression

Peng

Luo

et al. 2022

Preprint

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Background The pathways and mechanisms underlying the associations between the gut microbiome and the brain are collectively known as the microbiome-gut-brain axis (MGBA). Depression is a common and frequent psychological and psychiatric disease. The interactions comprising the MGBA may play a role in the pathogenesis of depression. Nevertheless, the general aspects of the links between the MGBA and depression have not been systematically investigated through bibliometric analysis. Methods Publications from 1994 to 2022, focusing on the links between the MGBA and depression, were downloaded from the Web of Science Core Collection. HistCite, VOSviewer, CiteSpace, and the Bibliometrix Package and were used for bibliometric analysis and visualization. The main analyses we performed included collaboration network analysis, co-citation analysis, co-occurrence analysis, and citation burst detection. Results A total of 829 publications related to the relationship between the MGBA and depression were identified. The number of such publications has been rapidly growing since 2014. The People's Republic of China, University College Cork, and John F. Cryan were the most influential country, institute, and scholar, respectively. BRAIN BEHAV IMMUN and NUTRIENTS were the most productive and co-cited journals. Five hot topics in research linking the MGBA with depression were depression, gut microbiota, gut-brain axis, microbiota, and anxiety. Five frontier topics in the field were cytokine, maternal separation, neuroinflammation, probiotics, and vagus. The most representative and symbolic reference with the highest co-citation number was an article by Bravo J. A. et al. (2011). Conclusions These results provide an instructive perspective for research on the relationship between the MGBA and depression, and a timely review and analysis of research hotspots and research trends, which will promote the development of this field. Future research will focus on understanding the underlying mechanism of action of the MGBA on depression, and on elucidating microbial-based interventions and treatment strategies for depression.

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Section: Discussionmentioning

confidence: 99%

Bibliometric and Visual Analysis of Research on the Links between the Microbiome-Gut-Brain axis and Depression

Peng

Luo

et al. 2022

Preprint

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“…In other words, the wide range of neuropsychiatric symptoms co-occurring in IBS could suggest common pathophysiological pathways of action or bidirectional potentiation of gastrointestinal, non-gastrointestinal, and socio-affective symtompatology. In this context, Aziz et al [24] and Cafer and Okan [14], respectively, showed that affective behaviour and sleep regulating brain areas changes were significantly associated with dysbiosis and IBS all of which could be relevant evidence for anxyiolitic and antidepressant treatments efficiency in IBS-associated symptoms alleviation, as shown by Cafer and Okan [14].…”

Section: Neuropsychiatric Comorbidities In Ibsfrom Start To What End?mentioning

confidence: 98%

A Preliminary view on some Genetic Aspects of Irritable Bowel Syndrome with regards to Neuropsychiatric Manifestations –

Luta¹,

Lefter²,

Ciobîcă³

et al. 2022

AnnalsARSciBio

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Since the newest functional gastrointestinal disorders diagnostic criteria (ROME IV), the formely functional bowel disorder – irritable bowel syndrome (IBS) – is currently known as a common chronic disorder of the brain – gut interaction. The main clinical symptomatology including abdominal pain, discomfort, and altered gastrointestinal motility, as well as the absence of any organic impairment or significant histological changes led to the confirmed hypothesis of multicomponent pathology and multifactorial etiogenesis. Thus, considering our previous experience in this area of research, this mini-review aimed to present a preliminary view of the possible genetic component underlying or predisposing to neurolopsychiatric and gastrointestinal impairments co-ocurring in IBS.

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“…Table 4 is a summary of the proposed factors as the cause of IBS and their role in the pathophysiology of the disease process of IBS. Serotonin reuptake receptor (SERT) and sucrose isomaltase (SCN5A) have been reported in IBS [17,18].…”

Section: Pathophysiology Of Ibsmentioning

confidence: 99%

The Role of Gut-Microbiota in the Pathophysiology and Therapy of Irritable Bowel Syndrome: A Systematic Review

Shrestha¹,

Patel²,

Shah³

et al. 2022

Cureus

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Irritable Bowel Syndrome (IBS) is one of the most prevalent chronic gastrointestinal diseases, which is characterized by recurrent abdominal pain and altered bowel habits. The pathophysiological mechanisms are not completely clear for IBS, multiple factors such as genetic, psychosocial, environmental, visceral hypersensitivity, low-grade inflammation, gastrointestinal motility changes, food components, and intestinal microbiota are thought to play a role in the disease process of IBS. The rapid progression of recent microbiome research using advanced microbiological technologies has shed light on dysbiosis related to the pathophysiology of IBS. We used PubMed, PubMed Central, and Medline as our primary databases to search for articles using keywords and medical subject heading (MeSH) keywords on April 30, 2022, to render a total of 4062 articles. Then, a total of 10 articles were selected following a quality assessment. Despite the variable findings in different studies, most studies have concluded that IBS patients have a reduction in bacterial diversity and an increase in the temporal instability of the microbiota. IBS is known as a stress disorder, and the gut-microbiome-brain axis has been associated with the pathogenesis of the disease. Additionally, the potential of dietary manipulation of gut microbiota and the use of probiotics, prebiotics, and synbiotics in the treatment of IBS has been studied in recent years and shown promising results. We concluded that the gut microbiome plays a substantial role in the pathophysiology of IBS.

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Irritable Bowel Syndrome, Depression, and Neurodegeneration: A Bidirectional Communication from Gut to Brain

Cited by 67 publications

References 122 publications

Bibliometric and Visual Analysis of Research on the Links between the Microbiome-Gut-Brain axis and Depression

Bibliometric and Visual Analysis of Research on the Links between the Microbiome-Gut-Brain axis and Depression

A Preliminary view on some Genetic Aspects of Irritable Bowel Syndrome with regards to Neuropsychiatric Manifestations –

The Role of Gut-Microbiota in the Pathophysiology and Therapy of Irritable Bowel Syndrome: A Systematic Review

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