Irritable bowel syndrome in twins: Heredity and social learning both contribute to etiology

Levy, Rona L.; Jones, Kenneth R.; Whitehead, William E.; Feld, Shara I.; Talley, Nicholas J.; Corey, Linda A.

doi:10.1053/gast.2001.27995

Cited by 377 publications

(264 citation statements)

References 11 publications

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“…The parental history was an independent risk factor for IBS diagnosis after adjusting for trait anxiety, depression and perceived stress. These results supported the results from the twin study in the USA 4 and Australia. 5 Furthermore, IBS patients with parental history had significantly higher scores of major symptoms for IBS (7-point scales); abdominal pain, abdominal discomfort, changes in bowel movement with abdominal pain/discomfort and softer stools with abdominal pain/discomfort than those without the history.…”

supporting

confidence: 90%

Development of irritable bowel syndrome may be associated with a parental history of bowel problems

Kanazawa

Fukudo

2005

Aliment Pharmacol Ther

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supporting

confidence: 90%

Development of irritable bowel syndrome may be associated with a parental history of bowel problems

Kanazawa

Fukudo

2005

Aliment Pharmacol Ther

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“…Because monozygotic twins share the exact same genetic code and dizygotic twins share half of the same genetic code, comparing concordance rates between monozygotic and dizygotic twins allows the opportunity to quantitate the contributions that genetics and environment each make to the development of the disease. Five twin studies demonstrate that the genetic contribution to IBS appears to range between 0 and 20% (8)(9)(10)(11)(12). The reasons for the heterogeneity in genetic liability estimates are not clear; they may represent true population-based differences, but are likely the result of methodological differences with respect to how IBS status was defined and how the information was collected.…”

Section: What Evidence Is There For An Ibs Gene?mentioning

confidence: 99%

The Genetics of Irritable Bowel Syndrome

Saito

Petersen

Locke

et al. 2005

Clinical Gastroenterology and Hepatology

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Irritable bowel syndrome (IBS) is one of the most common diagnoses made by gastroenterologists and primary care providers alike, and yet the underlying mechanism remains poorly understood. Family and twin studies suggest that IBS may have a genetic basis. Several candidate gene association studies have been performed, but thus far, they have failed to clearly identify an "IBS gene." Epidemiological studies are needed to facilitate phenotype definition and identify relevant environment risk factors that will need to factor in gene and environment interactions in all future genetic studies. As genetic research in IBS is relatively nascent, much opportunity, as well as many challenges, exists in identifying the genes responsible for IBS.

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“…3,4 Thus far, numerous factors have been implicated in the development of IBS. The aetiology of IBS is thought to be genetic [5][6][7][8][9][10] ; however, the genetic penetrance is incomplete, 11 suggesting that the genetic component of IBS could involve other unknown factors. Indeed, environmental factors such as diet (for a review, see 12,13 ) and stress (for a review, see [14][15][16][17] ) can impact gut physiology.…”

Section: Introductionmentioning

confidence: 99%

Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome

Matricon

Méleine

Gelot

et al. 2012

Aliment Pharmacol Ther

187

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This uncommissioned review article was subject to full peer-review. SUMMARY BackgroundIrritable bowel syndrome (IBS), one of the most common gastrointestinal disorders, markedly impairing patients' quality of life. Drug development for IBS treatment has been hampered by the lack of understanding of IBS aetiology. In recent years, numerous data have emerged that suggest the involvement of immune activation in IBS, at least in a subset of patients. AimTo determine whether immune activation and intestinal permeabilisation are more frequently observed in IBS patients compared with healthy controls. MethodsThe scientific bibliography was searched using the following keywords: irritable bowel syndrome, inflammation, immune activation, permeabilisation, intestine, assay, histology and human. The retrieved studies, including blood, faecal and histological studies, were analysed to provide a comprehensive and structured overview of the available data including the type of assay, type of inflammatory marker investigated or intestinal segment studied. ResultsImmune activation was more frequently observed in IBS patients than in healthy controls. An increase in the number of mast cells and lymphocytes, an alteration in cytokine levels and intestinal permeabilisation were reported in IBS patients. No consistent changes in the numbers of B cells or enterochromaffin cells or in mucosal serotonin production were demonstrated. ConclusionsThe changes observed were modest and often heterogeneous among the studied population. Only appropriate interventions improving irritable bowel syndrome symptoms could highlight and confirm the role of immune activation in this pathophysiology.

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Irritable bowel syndrome in twins: Heredity and social learning both contribute to etiology

Cited by 377 publications

References 11 publications

Development of irritable bowel syndrome may be associated with a parental history of bowel problems

Development of irritable bowel syndrome may be associated with a parental history of bowel problems

The Genetics of Irritable Bowel Syndrome

Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome

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