Irritable bowel syndrome is associated with novel inflammatory markers derived from hemogram parameters

Abstract

Background. Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is associated with sub-clinical inflammation. Some hemogram parameters are thought to be novel inflammatory markers. Objectives. We aimed to study novel inflammatory markers derived from hemograms and to compare them to those in healthy subjects. Material and methods. The platelet distribution width (PDW), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) of patients with IBS were gathered from a database and compared to those in a healthy population.Results. The PLR of the IBS group (144 ± 50%) was higher than the PLR of the control group (111 ± 32%; p < 0.001). The PDW of the IBS group (16.3 [1%]) was higher than the PDW of the control group (15.4 [2.4%]; p < 0.001). The NLR of the IBS group (2.2 [1.1%]) was higher than the NLR of the control group (1.8 [0.7%]; p < 0.001). The MLR of the IBS group (0.25 [0.14%]) was higher than the MLR of the control group (0.2 [0.12%]; p < 0.001). Conclusions. We think that PDW, NLR, PLR, and MLR could all serve as diagnostic tools for IBS. Although the diagnosis of IBS is based on history and clinical findings, the simplicity and low cost of these hemogram tests could provide laboratory support in establishing a diagnosis, especially in suspected cases.

Thrombocytopenia as a Diagnostic Marker for Malaria in Patients with Acute Febrile Illness

“…The suggested mechanism of accelerated clearance or consumption of platelets during malarial infection includes disseminated intravascular coagulation (DIC), immune-mediated destruction, pooling within the reticuloendothelial system, sequestration in the microcirculation, and malaria-mediated apoptosis [ 13 – 16 ]. In contrast to this study, a study was reported no association between the mean platelet count and irritable bowel syndrome [ 35 ]. A study was reported no difference between mean platelet count and TSH levels between the malignant thyroid nodule group and benign nodule group [ 36 ].…”

Evaluation of hematological parameters as an indicator of disease severity in Covid‐19 patients: Pakistan's experience

“…PLR is also identified as a diagnostic tool in inflammatory bowel syndrome. 23 Similarly, Mean…”

“…22 It can also as a diagnostic tool in inflammatory bowel disease. 23 This ratio has also been considered as a determinant of outcomes of various malignancies and coronary arterial diseases as well as patients suffering from recurrent ulcerative colitis. All these conditions are associated with overt inflammation as in COVID-19.…”

Relationship between blood neutrophil‐lymphocyte ratio and renal tubular atrophy/interstitial fibrosis in IgA nephropathy patients

“…NLR has been suggested to be associated with cardiac arrhythmia, 4 thyroiditis, 5 malignant nodules, 6 diabetes mellitus, 7 inflammatory bowel disease, 8 and irritable bowel syndrome. 9 All these conditions are characterized with overt or subtle inflammation, alike with IgA nephropathy. Yang H 10 found that NLR could predict the response to corticosteroids in IgAN.…”