Irritable bowel syndrome is strongly associated with generalized anxiety disorder: a community study

Lee, S.; Wu, Justin C. Y.; L., Y.; Tsang, Adley; Guo, Wanjun; Sung, Joseph J.Y.

doi:10.1111/j.1365-2036.2009.04074.x

Cited by 109 publications

(100 citation statements)

References 38 publications

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“…It was also shown in this study that there were more significant functioning disturbances among people with comorbid IBS and general anxiety disorder. In the current study, lifetime prevalence rates of anxiety and depressive disorders in the control group with GERD are similar to the prevalence rates obtained from epidemiological studies in the general population (anxiety disorders 30% vs. 25%, depressive disorders 16% vs. 16%;) [24][25][26], whereas in the group with IBS the prevalence rates ranged from 15% to 52% with respect to depressive disorders and from 22% to 44% with respect to anxiety disorders [13,[27][28][29][30][31][32][33].…”

Section: Discussionsupporting

confidence: 63%

“…In comparison with these data, in patients with IBS the prevalence of specific phobias, general anxiety disorder and agoraphobia was higher than in the general population, whereas social phobia and anxiety disorder with panic attacks occurred in individuals with IBS less frequently than in the general population. The higher prevalence of general anxiety disorder among IBS patients was pointed out by Lee et al [25]. In a random sample from the general population general anxiety disorder was 5 times more frequent in subjects with a diagnosis of IBS than in people without IBS.…”

Section: Discussionmentioning

confidence: 84%

“…According to the available literature, there is a higher prevalence of anxiety disorders among patients with IBS than in the general population (47% vs. 26%) [24,25]. Data showing that depressive disorders are also more prevalent in the group of patients with IBS in comparison to general population (33% vs. 16%) were published in an earlier article [26].…”

Section: Discussionmentioning

confidence: 92%

See 2 more Smart Citations

The Lifetime Prevalence of Anxiety Disorders Among Patients with Irritable Bowel Syndrome

Grzesiak¹,

Beszłej²,

Mulak³

et al. 2014

Adv Clin Exp Med

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Background. The prevalence of irritable bowel syndrome (IBS), the most common functional gastrointestinal disorder, ranges from 10% to 20% in the general population. It is estimated that from 40% to 90% of persons with a diagnosis of IBS suffer from mental disorders, mainly anxiety and depressive disorders. Objectives. The aim of the study was to assess the lifetime prevalence of anxiety disorders in IBS patients and to compare it with the prevalence of these disorders in a control group of patients with gastroesophageal reflux disease (GERD). Material and Methods. The study included 106 patients with IBS and 53 patients with GERD. IBS was diagnosed according to the Rome II criteria after a basic evaluation to exclude an organic disease. Anxiety disorders were diagnosed using the Composite International Diagnostic Interview (CIDI) in accordance with ICD-10 diagnostic criteria. Results. Anxiety disorders during the patient's lifetime were diagnosed in 50 IBS patients (47%). Specific phobias occurred in 23.5% of them, social phobias in 10.4 %, generalized anxiety disorder in 10.4%, panic disorder in 3.8% and agoraphobia in 8.5%. In the control group with GERD, anxiety disorders during the subject's lifetime were diagnosed in 30% of the group. The difference in the prevalence of anxiety disorders between patients with IBS and GERD was statistically significant (p < 0.05). Conclusions. The lifetime prevalence of anxiety disorders in IBS patients was higher than in the control group with GERD (47% vs. 30%). The prevalence rate of anxiety disorders in the control group with GERD was similar to the prevalence rate in the general population (Adv Clin Exp Med 2014, 23, 6, 987-992).

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

The Lifetime Prevalence of Anxiety Disorders Among Patients with Irritable Bowel Syndrome

Grzesiak¹,

Beszłej²,

Mulak³

et al. 2014

Adv Clin Exp Med

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“…In another epidemiological study done in Hong Kong, the prevalence of GAD was seen to be considerably higher in subjects reporting symptoms of IBS compared to those who did not, and IBS was found to be associated with a 6-fold higher chance of having GAD. 42 In a study done by Kabra and Nadkarni 43 in India, the prevalence of depression in IBS patients was about 37% which is slightly higher than our study. The probable reason being different scales were used to assess depression in the 2 studies.…”

Section: Discussioncontrasting

confidence: 48%

Psychiatric Co-morbidity in Patients With Irritable Bowel Syndrome at a Tertiary Care Center in Northern India

Kawoos

Wani

Kadla

et al. 2017

J Neurogastroenterol Motil

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Background/AimsIrritable bowel syndrome (IBS) is a chronic psycho-physiological disorder. It is considered to be the most common functional gastrointestinal disorder, and about 50-90% of IBS patients have associated psychiatric co-morbidity. We aimed to study psychiatric co-morbidities in patients with IBS visiting a tertiary care center. MethodsThis was a cross-sectional case-control study conducted over a duration of one and a half years from January 2014 to July 2015. Patients were selected from the out-patient department of gastroenterology. About 160 patients with IBS who fulfilled the inclusion criteria and who gave written informed consent were selected as study cases. The healthy attendants of cases were selected as controls. A total of 200 controls were selected. Rome-III criteria were used to diagnose IBS. For diagnosing psychiatric disorders, we used the Mini International Neuropsychiatric Interview Schedule Plus. ResultsMean age of our cases and controls was 39.7 ± 11.4 and 37.7 ± 9.6 years, respectively. Females outnumbered males in our cases as well as their controls by a ratio of 2:1 approximately. Psychiatric disorders were seen in 84.4% of IBS patients as compared to 41.5% in controls. Major psychiatric disorders seen in our patients were generalized anxiety disorders (30.0%) and depression (28.0%). ConclusionsThe majority of patients with IBS who present to a tertiary care center have co-morbid psychiatric disorders. We need to screen these patients for such co-morbidities and develop a holistic approach for better outcome in such cases.

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“…Furthermore, the DSM-IV-TR included diarrhea as a feature associated with GAD (American Psychiatric Association, 2000), and approximately one-quarter of the GAD patients have comorbid irritable bowel syndrome (Gros, Antony, McCabe, & Swinson, 2009;Lee, Wu, Ma, Tsang, Guo & Sung, 2009). Accordingly, CC rats exhibit increased defecation and colonic hypermotility (increased number of colonic spike bursts) in the conditioned context (Antoniadis & McDonald, 1999;Gue, Junien, & Bueno, 1991;Verleye & Gillardin, 2004).…”

Section: Face Validitymentioning

confidence: 99%

Contextual conditioning in rats as an animal model for generalized anxiety disorder

Luyten

Vansteenwegen

Kuyck

et al. 2011

Cogn Affect Behav Neurosci

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Animal models of psychiatric disorders are important translational tools for exploring new treatment options and gaining more insight into the disease. Thus far, there is no systematically validated animal model for generalized anxiety disorder (GAD), a severely impairing and difficult-to-treat disease. In this review, we propose contextual conditioning (CC) as an animal model for GAD. We argue that this model has sufficient face validity (there are several symptom similarities), predictive validity (it responds to clinically effective treatments), and construct validity (the underlying mechanisms are comparable). Although the refinement and validation of an animal model is a never-ending process, we want to give a concise overview of the currently available evidence. We suggest that the CC model might be a valuable preclinical tool to enhance the development of new treatment strategies and our understanding of GAD.

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Irritable bowel syndrome is strongly associated with generalized anxiety disorder: a community study

Abstract: SUMMARY BackgroundNo previous study has examined the comorbidity of Irritable Bowel Syndrome (IBS) and Generalized Anxiety Disorder (GAD) in a general population using standardized diagnostic methods.

Cited by 109 publications

References 38 publications

The Lifetime Prevalence of Anxiety Disorders Among Patients with Irritable Bowel Syndrome

The Lifetime Prevalence of Anxiety Disorders Among Patients with Irritable Bowel Syndrome

Psychiatric Co-morbidity in Patients With Irritable Bowel Syndrome at a Tertiary Care Center in Northern India

Contextual conditioning in rats as an animal model for generalized anxiety disorder

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