Irritable bowel syndrome subtypes differ in body awareness, psychological symptoms and biochemical stress markers

Eriksson, Ejnar; Andrén, Kerstin; Eriksson, Henry; Kurlberg, G.

doi:10.3748/wjg.14.4889

Cited by 57 publications

(56 citation statements)

References 44 publications

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“…Our findings that there were no statistically significant differences in QOL and SCL-90-R scores between IBS subtypes are consistent with the results of other previous research (Katsinelos et al, 2009;Park et al, 2009;Jamali et al, 2012). However, Eriksson et al (2008) found that QOL was lower in IBS-C and IBS-M when compared with other subtypes, and showed that the mean psychosocial scores were higher in IBS-M and IBS-C compared with IBS-D. This can be explained by the different types of questionnaires, cultures, and selected subjects.…”

Section: Discussionsupporting

confidence: 93%

A cross-sectional study of irritable bowel syndrome in nurses in China: prevalence and associated psychological and lifestyle factors

Liu

Xiao

Yao

2014

J. Zhejiang Univ. Sci. B

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Abstract:The prevalence of irritable bowel syndrome (IBS) and associated factors, especially psychological and lifestyle factors, in nurses in China have not been investigated previously. The aims of this study were to assess the prevalence of IBS in nurses, to evaluate whether factors, such as psychological disorders, are associated with IBS, and to determine whether psychological disorders can influence the severity of symptoms of IBS and quality of life (QOL). A cross-sectional study was conducted for Chinese nurses from November 2012 to February 2013. Participants were asked to complete questionnaires. The prevalence of IBS was 17.4%. The revised symptom checklist 90 (SCL-90-R) scores were significantly higher for nurses with IBS than for those without IBS (P<0.001), and no difference in scores between IBS subtypes was found (F=1.893, P=0.142). The scores of QOL for nurses with and without IBS were 77.18±21.93 and 88.44±11.89 (P<0.001), respectively. Psychological disorders did not show statistically significant correlations with severity of symptoms of IBS or QOL. Alcohol consumption, low level of exercise, and psychological disorders were risk factors for IBS. In summary, nurses in China show a high prevalence of IBS. Psychological disorders and some related lifestyle factors are probably responsible for the development of IBS in nurses.

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Section: Discussionsupporting

confidence: 93%

A cross-sectional study of irritable bowel syndrome in nurses in China: prevalence and associated psychological and lifestyle factors

Liu

Xiao

Yao

2014

J. Zhejiang Univ. Sci. B

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“…In this latter study, there was a higher prevalence of psychiatric comorbidity, and IBS patients (bowel habit not specified) had a blunted waking cortisol, which contrasts with findings of most studies. (Eriksson et al, 2008; Patacchioli et al, 2001; Suarez-Hitz et al, 2012)…”

Section: Discussionmentioning

confidence: 99%

The effect of sex and irritable bowel syndrome on HPA axis response and peripheral glucocorticoid receptor expression

Videlock

Shih

Adeyemo

et al. 2016

Psychoneuroendocrinology

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Background and aims Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been reported in irritable bowel syndrome (IBS). Enhanced HPA axis response has been associated with reduced glucocorticoid receptor (GR) mediated negative feedback inhibition. We aimed to study the effects of IBS status, sex, or presence of early adverse life events (EAL) on the cortisol response to corticotropin-releasing factor (CRF) and adrenocorticotropic hormone (ACTH), and on GR mRNA expression in peripheral blood mononuclear cells (PBMCs). Methods Rome III+ IBS patients and healthy controls underwent CRF (1 μg/kg ovine) and ACTH (250 μg) stimulation tests with serial plasma ACTH and cortisol levels measured (n = 116). GR mRNA levels were measured using quantitative PCR (n = 143). Area under the curve (AUC) and linear mixed effects models were used to compare ACTH and cortisol response measured across time between groups. Results There were divergent effects of IBS on the cortisol response to ACTH by sex. In men, IBS was associated with an increased AUC (p = 0.009), but in women AUC was blunted in IBS (p = 0.006). Men also had reduced GR mRNA expression (p = 0.007). Cumulative exposure to EALs was associated with an increased HPA response. Lower GR mRNA was associated with increased pituitary HPA response and increased severity of overall symptoms and abdominal pain in IBS. Conclusion This study highlights the importance of considering sex in studies of IBS and the stress response in general. Our findings also provide support for PBMC GR mRNA expression as a peripheral marker of central HPA response.

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“…The study from Eriksson and Andre,[27] who investigated the differences in somatic, psychological and biochemical patterns between the subtypes of IBS, showed that IBS-C patients had higher psychological symptoms and higher prolactin values than IBS-D patients. However, the IBS-D group showed dysfunctional body awareness and higher C-peptide values, probably reflecting an altered adrenergic drive.…”

Section: Discussionmentioning

confidence: 99%

Anxiety, depression and distress among irritable bowel syndrome and their subtypes: An epidemiological population based study

et al. 2016

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Background:Psychiatric disorders are common in irritable bowel syndrome (IBS). We conducted this study to investigate the relationship of IBS and their subtypes with some of psychological factors.Materials and Methods:A cross-sectional study was performed among 4763 staff of Isfahan University of Medical Sciences in 2011. Modified ROME III questionnaire and Talley Bowel Disease Questionnaire were used to evaluate IBS symptoms. Hospital Anxiety and Depression Scale and 12-item General Health Questionnaire were utilized to assess anxiety, depression and psychological distress. Logistic regression analysis was used to determine the association of psychological states and IBS in the total subject and both genders.Results:About, 4763 participants with mean age 36/58 ± 8/09 were included the 2106 males and 2657 females. Three thousand and seven hundred and seventy-six (81.2%) and 2650 (57.2%) participants were married and graduated respectively. Subtype analysis of IBS and its relationship with anxiety, depression and distress comparing the two genders can be observed that: IBS and clinically-significant IBS have higher anxiety, depression symptoms, and distress than the subject without IBS (P < 0.001). Women with IBS, have higher scores than men (P < 0.001). Compared to other subtypes, mixed IBS subtype has a higher anxiety, depression, and distress score.Conclusion:A high prevalence of anxiety, depression symptoms and distress in our subjects emphasize the importance of the psychological evaluation of the patients with IBS, in order to better management of the patients and may also help to reduce the burden of health care costs.

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Irritable bowel syndrome subtypes differ in body awareness, psychological symptoms and biochemical stress markers

Abstract: Abstract

Cited by 57 publications

References 44 publications

A cross-sectional study of irritable bowel syndrome in nurses in China: prevalence and associated psychological and lifestyle factors

A cross-sectional study of irritable bowel syndrome in nurses in China: prevalence and associated psychological and lifestyle factors

The effect of sex and irritable bowel syndrome on HPA axis response and peripheral glucocorticoid receptor expression

Anxiety, depression and distress among irritable bowel syndrome and their subtypes: An epidemiological population based study

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