Irritable bowel syndrome with food‐related symptoms: Future directions in the clinical management

Melchior, Chloé; Algera, Joost P.; Colomier, Esther; Törnblom, Hans; Simrén, Magnus

doi:10.1002/ueg2.12265

Cited by 6 publications

(4 citation statements)

References 44 publications

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“…The Hospital Anxiety and Depression scale contains 14 items and consists of two subscales: anxiety and depression. Each item is rated on a four-point scale, giving a maximum score of 21 for the total HADS score and anxiety and depression subscales according to Sun Cho et al [ 19 ], Melchior et al [ 20 ], and Groeger et al [ 21 ] for IBS subjects with values ≥ 8.…”

Section: Methodsmentioning

confidence: 99%

The Effects of Agave Fructans in a Functional Food Consumed by Patients with Irritable Bowel Syndrome with Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial

Camacho-Díaz,

Arenas-Ocampo,

Osorio-Díaz

et al. 2023

Nutrients

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Irritable bowel syndrome displays three different subtypes: constipation (IBS-C), diarrhea (IBS-D), and mixed (IBS-M). Treatment with dietary fiber is used, with consideration given both to the chemical composition of the fiber and to the different subtypes of IBS. The IBS-D subtype is usually treated with a low-FODMAPs diet, whereas the IBS-C subtype suggests prebiotics and probiotics to promote microbiota restoration. The aim of this study was to assess the effects of employing agave fructans as the soluble fiber of a jelly (Gelyfun®gastro) containing 8 g per serving in the IBS-C group (n = 50), using a randomized, double-blind, time-limited trial for four weeks. We evaluated changes in the frequency and types of bowel movements through the Bristol scale, and the improvement of the condition was evaluated using quality of life (IBS-QOL) and anxiety–depression (HADS) scales. The main results were that the number of bowel movements increased by more than 80%, with at least one stool per day from fifteen days onwards, without a laxative effect for the group treated. Finally, the quality of life with the prebiotic jelly was significantly improved compared to the placebo in all specific domains, in addition to significantly reducing anxiety and depression.

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Section: Methodsmentioning

confidence: 99%

The Effects of Agave Fructans in a Functional Food Consumed by Patients with Irritable Bowel Syndrome with Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial

Camacho-Díaz,

Arenas-Ocampo,

Osorio-Díaz

et al. 2023

Nutrients

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“…Although its etiology is not completely understood, 2 different therapeutic approaches are available, be it with limited efficacy. 5 More than 70% of IBS patients report that their symptoms are worsened by the meal, 6 , 7 and therefore, lately, dietary interventions have gained more attention. 8 , 9 The first-line approach for the treatment of IBS consists in encouraging healthy eating and lifestyle changes 5 , 10 according to the National Institute for Health and Care Excellence (NICE) guidelines and the British Dietetic Association (BDA).…”

Section: Introductionmentioning

confidence: 99%

DOMINO trial post hoc analysis: evaluation of the diet effects on symptoms in IBS subtypes

Di Rosa,

Van den Houte,

Altomare

et al. 2024

Therap Adv Gastroenterol

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Background: Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction characterized by recurrent abdominal pain related to defecation and/or associated to a change in bowel habits. According to the stool type, four different IBS subtypes can be recognized, constipation predominant (IBS-C), diarrhea predominant (IBS-D), mixed (IBS-M), and undefined (IBS-U). Patients report that their IBS symptoms are exacerbated by food. Thus, it is important to find a nutritional approach that could be effective in reducing IBS symptoms. Objective: The present work is a post hoc analysis of the previously published DOMINO trial. It aimed to evaluate the effects of a self-instructed FODMAP-lowering diet smartphone application on symptoms and psychosocial aspects in primary care IBS stratifying the results for each IBS subtypes. Design: Post hoc analysis. Methods: Two hundred twenty-two primary care IBS patients followed a FODMAP-lowering diet for 8 weeks with the support of a smartphone application. Two follow-up visits were scheduled after 16 and 24 weeks. IBS–Symptoms Severity Score (IBS-SSS), quality of life (QoL), and adherence and dietary satisfaction were evaluated. Results: After 8 weeks, IBS-SSS improved in all IBS subtypes ( p < 0.0001). Physician Health Questiionnaire (PHQ-15) improved only in IBS-D ( p = 0.0006), whereas QoL improved both in IBS-D ( p = 0.01) and IBS-M ( p = 0.005). Conclusion: This post hoc analysis showed that the app is useful in all IBS subtypes; thus, it could be used as an effective tool by both general practitioners and patients to manage symptoms in primary care. Trial registration: Ethical Commission University Hospital of Leuven reference number: S59482. Clinicaltrial.gov reference number: NCT04270487.

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“…It has also been convincingly demonstrated that diet can affect IBS, and this is the reason why many people tend to associate the various symptoms with nutrition. As a result, many patients tend to exclude certain foods from their diet on their own, or follow unsuitable nutritional patterns [ 17 , 18 ]. Although in the literature there is a lack of trials that evaluate the role of diet in the IBS-C subtype, this review aims to focus especially on the effects of fiber consumption on symptoms and microbiota.…”

Section: Introductionmentioning

confidence: 99%

Constipation-Predominant Irritable Bowel Syndrome (IBS-C): Effects of Different Nutritional Patterns on Intestinal Dysbiosis and Symptoms

et al. 2023

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Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by abdominal pain associated with defecation or a change in bowel habits. The pathogenesis of IBS is not completely clear, but it is known to be multifactorial and complex. Endogenous and exogenous factors such as abnormal GI motility, low-grade inflammation, increased epithelial permeability and visceral hypersensitivity, but diet and psychosocial aspects are also recognized as important actors. Furthermore, the interaction between diet and gut microbiota has gained interest as a potential contributor to the pathophysiology of IBS. To date, there is no specific diet for IBS with constipation (IBS-C); however, many studies show that fiber intake, especially soluble fiber such as inulin, could have a positive effect on symptoms. This review aims to evaluate the effects of some nutritional components such as fibers but also functional foods, prebiotics, probiotics and symbiotics on symptoms and microbiota in IBS-C subjects.

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Irritable bowel syndrome with food‐related symptoms: Future directions in the clinical management

Cited by 6 publications

References 44 publications

The Effects of Agave Fructans in a Functional Food Consumed by Patients with Irritable Bowel Syndrome with Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial

The Effects of Agave Fructans in a Functional Food Consumed by Patients with Irritable Bowel Syndrome with Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial

DOMINO trial post hoc analysis: evaluation of the diet effects on symptoms in IBS subtypes

Constipation-Predominant Irritable Bowel Syndrome (IBS-C): Effects of Different Nutritional Patterns on Intestinal Dysbiosis and Symptoms

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