Is a dopaminergic system involved in thyrotropin releasing hormone induced hyperthermia and in its potentiation by amphetamine?

Rips, Richard; Desiles, Marguerite; Puech, Alain J.

doi:10.1016/0364-7722(79)90044-4

Cited by 10 publications

(3 citation statements)

References 16 publications

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“…TRH-induced hyperthermia seems to depend specifically on the activation of an a-adrenergic system (Desiles, Constans & Rips, 1979;Rips, Desiles & Puech, 1979;. We have investigated the effects of new substances which possess antidepressant activity but which seem to have no a-adrenergic activity.…”

Section: Introductionmentioning

confidence: 99%

USE OF POTENTIATION OF THYROTROPHIN RELEASING HORMONE (TRH)‐INDUCED HYPERTHERMIA AS a TEST FOR SCREENING ANTIDEPRESSANTS WHICH ACTIVATE Α‐ADRENOCEPTOR SYSTEMS

Desiles

Rips

1981

British J Pharmacology

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1 The minimal dose which significantly potentiates the hyperthermia induced by thyrotrophin releasing hormone (TRH, 40mg/kgi.p.) in mice has been established for tricyclic and other antidepressants (imipramine, amitriptyline, clomipramine, nortriptyline, maprotiline, nomifensine, viloxazine) including a specific inhibitor of noradrenaline (NA) uptake (nisoxetine). 2 The minimal effective dose in this test has been compared with the minimal dose of the same compounds antagonizing reserpine-induced hypothermia. The ratio of the two doses for each substance indicates that potentiation of TRH-induced hyperthermia is, in general, the more sensitive test.3 A correlation seems to exist between the a-adrenergic effect of antidepressants and the potentiation of TRH-induced hyperthermia. Those antidepressants which do not act on aadrenergic systems (butriptyline, amineptine, trazodone, danitracen, fluoxetine) are inactive in this test. 4 This property may be used to select antidepressants that activate a-adrenoceptor systems.

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Section: Introductionmentioning

confidence: 99%

USE OF POTENTIATION OF THYROTROPHIN RELEASING HORMONE (TRH)‐INDUCED HYPERTHERMIA AS a TEST FOR SCREENING ANTIDEPRESSANTS WHICH ACTIVATE Α‐ADRENOCEPTOR SYSTEMS

Desiles

Rips

1981

British J Pharmacology

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“…It is not affected by agents acting on *dopamine (Rips, Desiles & Puech, 1979), 5-hydroxytryptamine or GABA receptors (Desiles, Constans & Rips, 1979). This suggests specific participation of an ax-adrenoceptor system.…”

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confidence: 99%

“…In contrast to some other effects of TRH such as increased motor activity which appear to involve a dopaminergic system (Heal & Green, 1979) hyperthermia is inhibited by a-adrenoceptor antagonists and potentiated by a-adrenoceptor agonists (Desiles & Rips, 1980). It is not affected by agents acting on *dopamine (Rips, Desiles & Puech, 1979), 5-hydroxytryptamine or GABA receptors (Desiles, Constans & Rips, 1979). This suggests specific participation of an ax-adrenoceptor system.…”

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confidence: 99%

INVOLVEMENT OF a CENTRAL Α‐ADRENOCEPTOR SYSTEM IN ANTIDEPRESSANT POTENTIATION OF HYPERTHERMIA INDUCED BY THYROTROPIN RELEASING HORMONE

Desiles

Puech

Rips

1980

British J Pharmacology

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Thyrotropin releasing hormone (TRH) causes hyperthermia in mice which is potentiated by tricyclic antidepressants (nortriptyline, imipramine, clomipramine, amitriptyline), the monoamine oxidase inhibitor, tranylcypromine, and various other antidepressants (maprotiline, nomifensin, viloxazine). Only iprindole is ineffective. The effect of mianserin, itself hypothermic, could not be interpreted. A property shared by the potentiating substances seems to be activation of a central adrenoceptor system. The potentiation of TRH-induced hyperthermia which seems to be specific to antidepressants might be used in the selection of antidepressants.

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Changes in body temperature after administration of adrenergic and serotonergic agents and related drugs including antidepressants

Clark

Lipton

1980

Neuroscience & Biobehavioral Reviews

105

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Is a dopaminergic system involved in thyrotropin releasing hormone induced hyperthermia and in its potentiation by amphetamine?

Cited by 10 publications

References 16 publications

USE OF POTENTIATION OF THYROTROPHIN RELEASING HORMONE (TRH)‐INDUCED HYPERTHERMIA AS a TEST FOR SCREENING ANTIDEPRESSANTS WHICH ACTIVATE Α‐ADRENOCEPTOR SYSTEMS

USE OF POTENTIATION OF THYROTROPHIN RELEASING HORMONE (TRH)‐INDUCED HYPERTHERMIA AS a TEST FOR SCREENING ANTIDEPRESSANTS WHICH ACTIVATE Α‐ADRENOCEPTOR SYSTEMS

INVOLVEMENT OF a CENTRAL Α‐ADRENOCEPTOR SYSTEM IN ANTIDEPRESSANT POTENTIATION OF HYPERTHERMIA INDUCED BY THYROTROPIN RELEASING HORMONE

Changes in body temperature after administration of adrenergic and serotonergic agents and related drugs including antidepressants

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