Is a healthy microbiome responsible for lower mortality in COVID-19?

Janda, Lubomír; Mihalčin, Matúš; Šťastná, Michaela

doi:10.2478/s11756-020-00614-8

Cited by 32 publications

(30 citation statements)

References 86 publications

(94 reference statements)

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“…The dysbiosis of the gut microbiota creates a suitable environment for SARS-CoV-2 replication and subsequent effects. The inflammatory proteins, cytokines and other mediators that are released because of gut dysbiosis will be augmented with coronavirus infection, which may induce a “cytokine storm” causing more damage than the virus alone, which can ultimately result in multiorgan injury[ 44 ]. Zuo et al [ 45 ] examined the effect of infection with SARS-CoV-2 on the gut microbiome.…”

Section: Implications Of Gastrointestinal Infection In Covid-19mentioning

confidence: 99%

Paediatric gastrointestinal disorders in SARS-CoV-2 infection: Epidemiological and clinical implications

Al‐Biltagi¹,

Saeed²,

Bediwy³

et al. 2021

WJG

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The coronavirus disease 2019 (COVID-19) pandemic is a threat worldwide for individuals of all ages, including children. Gastrointestinal manifestations could be the initial presenting manifestation in many patients, especially in children. These symptoms are more common in patients with severe disease than in patients with non-severe disease. Approximately 48.1% of patients had a stool sample that was positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA. Children typically form 1%-8% of all laboratory-confirmed cases of SARS-CoV-2. Gastrointestinal manifestations of COVID-19 in children are not rare, with a prevalence between 0 and 88%, and a wide variety of presentations, including diarrhoea, vomiting, and abdominal pain, can develop before, with or after the development of respiratory symptoms. Atypical manifestations such as appendicitis or liver injury could also appear, especially in the presence of multisystem inflammatory disease. In this review, we discussed the epidemiology of COVID-19 gastrointestinal diseases in children as well as their implications on the diagnosis, misdiagnosis, prognosis, and faecal-oral transmission route of COVID-19 and the impact of gastrointestinal diseases on the gut microbiome, child nutrition, and disease management.

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Section: Implications Of Gastrointestinal Infection In Covid-19mentioning

confidence: 99%

Paediatric gastrointestinal disorders in SARS-CoV-2 infection: Epidemiological and clinical implications

Al‐Biltagi¹,

Saeed²,

Bediwy³

et al. 2021

WJG

View full text Add to dashboard Cite

show abstract

“…Notably, although several papers have been published to recommend the use of probiotics in COVID-19 patients, which to some extent is supported by our data 44,45 , the e cacy of the intervention needs to be validated in rigorous clinical trials.…”

Section: Discussionmentioning

confidence: 58%

Dynamics of the Upper Respiratory Tract Microbiota and Its Association with Fatality in COVID-19 Patients

et al. 2020

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The pandemic of Coronavirus disease 2019 (COVID-19) is ongoing globally, which is a big challenge for public health. Alteration of human microbiota had been observed in COVID-19. However, it is unknown how the microbiota is associated with the fatality in COVID-19. We conducted metatranscriptome sequencing on 588 longitudinal oropharyngeal swab specimens collected from 192 COVID-19 patients recruited in the LOTUS clinical trial (Registration number: ChiCTR2000029308) (including 39 deceased patients), and 95 healthy controls from the same geographic area. The upper respiratory tract (URT) microbiota in COVID-19 patients differed from that in healthy controls, while deceased patients possessed a more distinct microbiota. Streptococcus was enriched in recovered patients, whereas potential pathogens, including Candida and Enterococcus, were more abundant in deceased patients. Moreover, the microbiota dominated by Streptococcus was more stable than that dominated by other species. In contrast, the URT microbiota in deceased patients showed a more signi cant alteration and became more deviated from the norm after admission. The abundance of Streptococcus on admission, particularly that of S. parasanguinis, was identi ed as a strong predictor of fatality by Cox and L 1 regularized logistic regression analysis, thus could be used as a potential prognostic biomarker of COVID-19. The generalization of the results in other populations and underlying mechanisms needs further investigations.

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“…patients, which to some extent is supported by our data 44,45 , the e cacy of the intervention needs to be validated in rigorous clinical trials. All patients were positive for SARS-CoV-2 RNA tested by RT-PCR assay (Shanghai ZJ Bio Tec or Sansure Biotech, China) before admission.…”

Section: Discussionmentioning

confidence: 69%

Dynamics of the upper respiratory tract microbiota and its association with fatality in COVID-19 patients

Ren

Wang

et al. 2020

Preprint

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The pandemic of Coronavirus disease 2019 (COVID-19) is ongoing globally, which is a big challenge for public health. Alteration of human microbiota had been observed in COVID-19. However, it is unknown how the microbiota is associated with the fatality in COVID-19. We conducted metatranscriptome sequencing on 588 longitudinal oropharyngeal swab specimens collected from 192 COVID-19 patients recruited in the LOTUS clinical trial (Registration number: ChiCTR2000029308) (including 39 deceased patients), and 95 healthy controls from the same geographic area. The upper respiratory tract (URT) microbiota in COVID-19 patients differed from that in healthy controls, while deceased patients possessed a more distinct microbiota. Streptococcus was enriched in recovered patients, whereas potential pathogens, including Candida and Enterococcus, were more abundant in deceased patients. Moreover, the microbiota dominated by Streptococcus was more stable than that dominated by other species. In contrast, the URT microbiota in deceased patients showed a more significant alteration and became more deviated from the norm after admission. The abundance of Streptococcus on admission, particularly that of S. parasanguinis, was identified as a strong predictor of fatality by Cox and L1 regularized logistic regression analysis, thus could be used as a potential prognostic biomarker of COVID-19. The generalization of the results in other populations and underlying mechanisms needs further investigations.

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Is a healthy microbiome responsible for lower mortality in COVID-19?

Cited by 32 publications

References 86 publications

Paediatric gastrointestinal disorders in SARS-CoV-2 infection: Epidemiological and clinical implications

Paediatric gastrointestinal disorders in SARS-CoV-2 infection: Epidemiological and clinical implications

Dynamics of the Upper Respiratory Tract Microbiota and Its Association with Fatality in COVID-19 Patients

Dynamics of the upper respiratory tract microbiota and its association with fatality in COVID-19 patients

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