Is administration n-3 fatty acids by enema mucosal protective against trinitrobenzene-induced colitis in rats?

Intestinal responsiveness to experimental colitis in young rats is altered by maternal diet

“…Consistent with this, the low incidence of IBD among the Inuit has been attributed to their habitual high intake of n-3 fatty acids, particularly eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) from marine foods (6). High dietary intakes of n-3 fatty acids have also shown therapeutic benefit in experimental models of colitis (1,36,37,49) and in several clinical studies including patients with ulcerative colitis and Crohn's disease (4,7,18,45). The absence of significant therapeutic efficacy in some clinical trials of n-3 fatty acids in patients with IBD (31,33) may be explained by differences in study design, patient selection, and the formulation, dose, and duration of n-3 fatty acids (6).…”

Role of Fatty Acids in the Resolution of Autoimmune and Inflammatory Diseases

“…Generally researches show that fish oil rich diet are involved in the amelioration of the disease comparing with n-6 fatty acid oil rich diet. In this way different studies have demonstrated convincingly the reduction on colonic damage and ulceration (Vilaseca et al, 1990;Yuceyar et al, 1999), reduction in cell recruitment and activation (Andoh et al, 2003;Whiting et al, 2005) decreasing levels of LTB 4 and PGE 2 on plasma and gut mucosa (Shoda et al, 1995;Nieto et al, 2002;Hudert et al, 2006) and reduction of pro-inflammatory cytokines (Andoh et al, 2003) in animals fed with n-3 PUFA rich diet. The effects of fatty acids on an animal model of Cronh's disease have been proved too.…”

Study of the effects of dietary polyunsaturated fatty acids: Molecular mechanisms involved in intestinal inflammation

“…The effects of dietary PUFA supplementation on disease severity are related to the production of proinflammatory eicosanoids. Four studies have found decreased colon or ileum damage and inflammation compared to n-6 PUFA diet in a rat model of chemically-induced colitis (Vilaseca et al, 1990;Empey et al, 1991;Yuceyar et al, 1999;Nieto et al, 2002). Vilaseca et al, (1990) compared the effects of dietary supplementation with either sunflower (n-6) or cod liver (n-3) oil on the development of chronic granulomatous lesions in the colon of a TNBS rat model.…”

“…In a TNBS-induced rat colitis model, the protective role of fish oil (n-3 PUFA) (both as an enriched diet, or administered intrarectally) was investigated (Yuceyar et al, 1999). The n-3 PUFA enriched diet showed a protective effect by decreasing production of LTB 4 and LTC 4 , and by decreasing activity of the myeloperoxidase, an enzyme which is stored in granules of polymorphonuclear neutrophils and macrophages and released into extracellular fluid in the setting of inflammatory processes.…”