2013
DOI: 10.3109/0886022x.2013.777891
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Is Administration of Preoperative Angiotensin-Converting Enzyme Inhibitors Important for Renal Protection after Cardiac Surgery?

Abstract: Objective: There are various reasons for renal dysfunction after cardiac surgery; however, activation of the reninangiotensin system has an important role following cardiac surgery. We investigated the effect of preoperative angiotensin-converting enzyme (ACE) inhibitors on renal functions after cardiovascular surgery. Material-methods: Three hundred sixty-six patients awaiting elective cardiac surgery were allocated to two groups, namely the treatment group, comprising the ACE inhibitor group (n ¼ 186), and t… Show more

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Cited by 6 publications
(2 citation statements)
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“…However, subsequent research, including small, randomized trials, failed to establish a definitive correlation between ACE inhibitor maintenance and major cardiac events ( van Diepen et al, 2018 ). Interestingly, studies showcasing a decrease in postoperative AKI in CABG patients continuing ACE inhibitors contrasted with our findings ( Benedetto et al, 2008 ; Drenger et al, 2012 ; Dag et al, 2013 ).…”
Section: Discussioncontrasting
confidence: 99%
See 1 more Smart Citation
“…However, subsequent research, including small, randomized trials, failed to establish a definitive correlation between ACE inhibitor maintenance and major cardiac events ( van Diepen et al, 2018 ). Interestingly, studies showcasing a decrease in postoperative AKI in CABG patients continuing ACE inhibitors contrasted with our findings ( Benedetto et al, 2008 ; Drenger et al, 2012 ; Dag et al, 2013 ).…”
Section: Discussioncontrasting
confidence: 99%
“…The European Association of Cardiothoracic Surgery (EACTS) guidelines recommend discontinuing ACE inhibitors 24–48 h before cardiac surgery due to the risk of postoperative AKI or vasoplegic shock ( Sousa-Uva et al, 2018 ). However, these recommendations lack definitive evidence, and some authors propose a potential protective role for ACE inhibitors ( Dag et al, 2013 ). The debate between withholding or continuing ACE inhibitors is still ongoing ( Tempe and Hasija, 2020 ).…”
Section: Introductionmentioning
confidence: 99%