Is aerosol delivery by high‐flow nasal cannula in children an effective alternative to face mask aerosol nebulization?

Kesavan, Sajith; Amirav, Israel

doi:10.1002/ppul.24480

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…Meanwhile, another study demonstrated that treatment with mometasone furoate nasal spray 100 mcg once daily for 1 year was well tolerated in children aged 6-11 years (47). Although aerosol therapy with nasal cannula is a common treatment in children, a new nasal nebulized system should be specifically designed for this pediatric population (48). According to current guidelines, intranasal steroids are considered safe during pregnancy.…”

Section: Nebulization Therapy For the Nasal Diseases In Special Populationmentioning

confidence: 99%

Chinese expert recommendation on transnasal corticosteroid nebulization for the treatment of chronic rhinosinusitis 2021

Cheng¹,

Li²,

Liu³

et al. 2021

J Thorac Dis

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Section: Nebulization Therapy For the Nasal Diseases In Special Populationmentioning

confidence: 99%

Chinese expert recommendation on transnasal corticosteroid nebulization for the treatment of chronic rhinosinusitis 2021

Cheng¹,

Li²,

Liu³

et al. 2021

J Thorac Dis

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“…As we navigate the post-pandemic world, the lessons learned from these behavioral changes will likely inform future preparedness for potential outbreaks and other public health challenges [5]. Continued public health education, accessible healthcare, and effective communication between governments and communities will be essential in sustaining a culture of protective behaviors to safeguard public health in the years to come [6]. Respiratory diseases can be more dangerous than other infections due to several key factors, which include their mode of transmission, the vital function of the respiratory system, and the potential for rapid spread within populations [7].…”

Section: Introductionmentioning

confidence: 99%

Personalized Nasal Protective Devices: Importance and Perspectives

Quoc,

Bácskay,

Fehér

et al. 2023

Life

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Nowadays, in addition to diseases caused by environmental pollution, the importance of personalized protection against various infectious agents has become of paramount importance. Besides medicine, several technical and technological studies have been carried out to develop suitable devices. One such revolutionary solution is the use of personalized nasal filters, which allow our body to defend itself more effectively against external environmental damage and pathogens. These filters are small devices that are placed in the nose and specifically filter the inhaled environmental contaminants, allergens, and microorganisms according to individual needs. These devices not only play a key role in maintaining our health but also contribute to environmental protection, reducing the inhalation of pollutants and their harmful impact on the natural environment. Another advantage of personalized filters is that they also provide an opportunity to strengthen our individual immune systems. The use of personalized filters allows medicine to provide optimized protection for everyone, focusing on individual genetic and immunological conditions. The momentum behind the development and research of personalized nasal filters has reached astonishing proportions today. Nowadays, many research groups and medical institutions are working to create new materials, nanotechnologies, and bioinformatics solutions in order to create even more effective personalized nasal filters that can also be shaped easily and safely. Considering the needs of the users is at least as important during development as the efficiency of the device. These two properties together determine the success of the product. Industry research focuses not only on improving the efficiency of devices, but also on making them more responsive to user needs, comfort, and portability. Based on all this, it can be concluded that personalized nasal filters can be a promising and innovative solution for protection against environmental pollutants and pathogens. Through a commitment to the research and development of technology, the long-term impact of such devices on our health and the environment can be significant, contributing to improving people’s quality of life and creating a sustainable future. With unique solutions and continuous research, we give hope that in the future, despite the environmental challenges, we can enjoy the protection of our health with even more efficient and sophisticated devices.

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“…Nebulization via the HFNC system instead of using traditional face masks improves patient comfort, but lung deposition of the drug has been shown to be very sensitive to the flow rate used. Moreover, during invasive ventilation the correct placement of the nebulizer within the circuit is essential (Berlinski 2017, Valencia-Ramos et al 2018, Kesavan and Amirav 2019, Li et al 2019. Clinical assessment is insufficient to recognize salbutamol responders reliably (Schramm et al 2017), so additional tools are needed to better guide the treatment.…”

Section: Introductionmentioning

confidence: 99%

Bronchodilator effect on regional lung function in pediatric viral lower respiratory tract infections

et al. 2022

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Objective Viral lower respiratory tract infections (LRTI) are the leading cause for acute admission to the intensive care unit in infants and young children. Nebulized bronchodilators are often used when treating the most severe cases. Aim of this study was to investigate the bronchodilator effect on respiratory mechanics during intensive care with electrical impedance tomography (EIT) and to assess the feasibility of EIT in this context. Approach We continuously monitored the children with chest EIT for up to 72h in an observational study design. The treatment decisions were done by clinical assessment, as the clinicians were blinded to the EIT information during data collection. In a retrospective analysis, clinical parameters and regional expiratory time constants determined by EIT were used to assess the effects of bronchodilator administration, especially regarding airway resistance. Main results We included six children from 11 to 27 months of age requiring intensive care due to viral LRTI and receiving bronchodilator agents. Altogether 131 bronchodilator administrations were identified during EIT monitoring. After validation of the exact timing of events and EIT data quality, 77 administrations were included in the final analysis. Fifty-five bronchodilator events occurred during invasive ventilation and 22 during high-flow nasal cannulae treatment. Only 17% of the bronchodilator administrations resulted in a relevant decrease in calculated expiratory time constants. Significance Continuous monitoring with EIT might help to optimize the treatment of LRTI in pediatric intensive care units. Especially EIT-based regional expiratory time constants would allow objective assessment of the effects of bronchodilators and other respiratory therapies.

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Is aerosol delivery by high‐flow nasal cannula in children an effective alternative to face mask aerosol nebulization?

Cited by 5 publications

References 10 publications

Chinese expert recommendation on transnasal corticosteroid nebulization for the treatment of chronic rhinosinusitis 2021

Chinese expert recommendation on transnasal corticosteroid nebulization for the treatment of chronic rhinosinusitis 2021

Personalized Nasal Protective Devices: Importance and Perspectives

Bronchodilator effect on regional lung function in pediatric viral lower respiratory tract infections

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