2019
DOI: 10.1002/rmb2.12299
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Is age‐related increase of chromosome segregation errors in mammalian oocytes caused by cohesin deterioration?

Abstract: BackgroundMammalian oocytes initiate meiosis in fetal ovary and are arrested at dictyate stage in prophase I for a long period. It is known that incidence of chromosome segregation errors in oocytes increases with advancing age, but the molecular mechanism underlying this phenomenon has not been clarified.MethodsCohesin, a multi‐subunit protein complex, mediates sister chromatid cohesion in both mitosis and meiosis. In this review, molecular basis of meiotic chromosome cohesion and segregation is summarized. F… Show more

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Cited by 14 publications
(9 citation statements)
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“…We showed that widespread sex differences in broad-scale crossover positioning (Sardell and Kirkpatrick, 2020) apply across house mice, even in lineages where the direction of heterochiasmy is reversed. Faster spermatogenesis may select for synchronization of the separation across all homologs within the cell (Kudo et al, 2009), whereas in oogenesis, the slower cell cycle and multiple arrest stages may require chromosome structures with greater stability on the meiosis I spindle, especially for those organisms that undergo dictyate arrest (Lee, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…We showed that widespread sex differences in broad-scale crossover positioning (Sardell and Kirkpatrick, 2020) apply across house mice, even in lineages where the direction of heterochiasmy is reversed. Faster spermatogenesis may select for synchronization of the separation across all homologs within the cell (Kudo et al, 2009), whereas in oogenesis, the slower cell cycle and multiple arrest stages may require chromosome structures with greater stability on the meiosis I spindle, especially for those organisms that undergo dictyate arrest (Lee, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…While elegant studies of DNA damage, spindle abnormalities and meiotic errors have provided unique insight into oocyte aging and meiotic failure (Mihajlović and FitzHarris, 2018;Gruhn et al, 2019;Zielinska et al, 2019;Hassold et al, 2020;Mikwar et al, 2020), advances in the application of proteomic and RNA-sequencing technology to oocytes are beginning to reveal an additional layer of complexity to this process whereby declining proteostasis contributes widely to maternal aging processes (Duncan et al, 2017). Our improved understanding of reproductive failure has been marked by the discovery that proteins critical for meiosis, such as those comprising the cohesion complex, are in fact extremely long-lived with no capacity for renewal during oocyte development (Revenkova et al, 2010;Tachibana-Konwalski et al, 2010;Burkhardt et al, 2016;Lee, 2020). Furthermore, evidence for deleterious PTMs of proteasome subunits coupled with declining proteasome activity in aged oocytes has given rise to novel streams of research into the maintenance of oocyte proteostasis (Mihalas et al, 2018).…”
Section: Protein Health During Reproductive Aging In Womenmentioning
confidence: 99%
“…4HNE also elicits a reduction in kinetochore-microtubule and tubulin polymerization that may contribute to oocyte aging and increases in aneuploidy (Mihalas et al, 2017(Mihalas et al, , 2018. Coupled with the knowledge that cohesin and several centromere-specific histones are long-lived proteins that deteriorate with age in the absence of renewal pathways (Revenkova et al, 2010;Tachibana-Konwalski et al, 2010;Burkhardt et al, 2016;Greaney et al, 2018;Lee, 2020), proteostasis defects either driven by oxidative modifications or the collapse of protein quality control over time, form a compelling explanation to support many aspects of oocyte aging and the loss of meiotic fidelity.…”
Section: The Contribution Of Declining Proteostasis To Oocyte Agingmentioning
confidence: 99%
“…Processes critical for meiosis include sister chromatid cohesion, synapsis, assembly of the synaptonemal complex and recombination. A large number of genes have been identified as having a role in these processes 29 . A systematic way of identifying which of these candidate genes might be associated with an increased risk of trisomy 21 is to evaluate any associations between gene variants and the presence of segregation errors.…”
Section: Family Historymentioning
confidence: 99%
“…A large number of genes have been identified as having a role in these processes. 29 A systematic way of identifying which of these candidate genes might be associated with an increased risk of trisomy 21 is to evaluate any associations between gene variants and the presence of segregation errors. A broader approach is to carry out a genome-wide association study (GWAS).…”
Section: Gene Variants That Predispose To Trisomymentioning
confidence: 99%