Is age-related macular degeneration associated with serum lipoprotein and lipoparticle levels?

Abalain, Jean-Hervé; Carré, Jean‐Luc; Leglise, D; Robinet, A.; F, Legall; Meskar, A.; Floch, H.H.; Colin, Joseph

doi:10.1016/s0009-8981(02)00288-7

Cited by 42 publications

(34 citation statements)

References 37 publications

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“…22,23,100 Abalain et al investigated the association between AMD and serum levels of lipoproteins and lipoparticles. 1 They found that there was no difference in serum ApoA-I and ApoB levels between AMD patients and controls. However, they found that serum ApoE levels were higher, and that serum ApoC-III levels were lower, in AMD patients compared with controls.…”

Section: Apolipoproteinsmentioning

confidence: 96%

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Transport and Retinal Capture of Lutein and Zeaxanthin with Reference to Age-related Macular Degeneration

Loane

Nolan

O'Donovan

et al. 2008

Survey of Ophthalmology

100

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Abstract. Age-related macular degeneration (AMD) is the most common cause of irreversible blindness in the elderly population in the western world. The etiology and pathogenesis of this disease remain unclear. However, there is an increasing body of evidence supporting the hypothesis that the macular pigment carotenoids, lutein and zeaxanthin, play an important role in protection against AMD, by filtering out blue light at a pre-receptoral level, or by quenching free radicals. Lutein and zeaxanthin are dietary xanthophyll carotenoids, which are delivered to the retina via plasma lipoproteins. The biological mechanisms governing retinal capture and accumulation of lutein and zeaxanthin, to the exclusion of other carotenoids, are still poorly understood. Although these mechanisms remain unclear, it is possible that selective capture of these carotenoids is related to lipoprotein, or apolipoprotein, function and profile. Xanthophyll-binding proteins appear to play an important role in the retinal capture of the xanthophyll carotenoids. The Pi isoform of GSTP1 has been isolated as a specific binding protein for zeaxanthin. The binding protein responsible for retinal uptake of lutein remains elusive. This article reviews the literature germane to the mechanisms involved in the capture, accumulation and stabilization of lutein and zeaxanthin by the retina, and the processes involved in their transport in serum. (Surv Ophthalmol 53:68--81, 2008 The central retina, known as the macula, is responsible for central and color vision because of its high concentration of cone photoreceptors. The macula is characterized by a yellow color, attributable to the presence of macular pigment. 81 Macular pigment (MP) is composed of lutein and zeaxanthin, two hydroxycarotenoids, which are entirely of dietary origin. 17 The concentration of MP peaks at the center of the macula, known as the fovea, where zeaxanthin is the dominant carotenoid. In contrast, lutein dominates in the parafoveal region. 16,82 Dietary sources 68

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Section: Apolipoproteinsmentioning

confidence: 96%

“…65 Abalain et al found no difference in the levels of this particular lipoparticle between AMD patients and controls. 1 The evidence to date suggests that, of the apolipoproteins, ApoE has the strongest association with AMD.…”

Section: Apolipoproteinsmentioning

confidence: 99%

Transport and Retinal Capture of Lutein and Zeaxanthin with Reference to Age-related Macular Degeneration

Loane

Nolan

O'Donovan

et al. 2008

Survey of Ophthalmology

100

View full text Add to dashboard Cite

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“…In particular, several investigators have suggested an association between ApoE and various diseases, including Alzheimer's disease, atherosclerosis and AMD. [77][78][79][80] Abalain et al investigated the association between AMD and serum levels of lipoproteins and lipoparticles. [78] They found that there was no difference in serum ApoA-I and ApoB levels between AMD patients and controls.…”

Section: Apolipoproteinsmentioning

confidence: 99%

“…[77][78][79][80] Abalain et al investigated the association between AMD and serum levels of lipoproteins and lipoparticles. [78] They found that there was no difference in serum ApoA-I and ApoB levels between AMD patients and controls. However, they found that serum ApoE levels were higher, and that serum ApoC-III levels were lower, in AMD patients compared with controls.…”

Section: Apolipoproteinsmentioning

confidence: 99%

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Lipoproteins and Apolipoproteins of the Ageing Eye

Loane¹

2012

Lipoproteins - Role in Health and Diseases

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Subclinical Atherosclerotic Cardiovascular Disease and Early Age-Related Macular Degeneration in a Multiracial Cohort

Klein

Knudtson

et al. 2007

Arch Ophthalmol

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Objective: To investigate the relationship of subclinical atherosclerotic cardiovascular disease (CVD) and its risk factors with age-related macular degeneration (AMD) in the Multiethnic Study of Atherosclerosis.Methods: This study included 6176 white, black, Hispanic, and Chinese participants aged 44 to 84 years from 6 communities in the United States. Measurements of subclinical CVD were performed according to standardized protocols. Fundus images were graded using the Wisconsin Age-Related Maculopathy Grading System. Results: In analyses controlled for age, sex, race/ ethnicity, and study location, early AMD was associated with a higher serum high-density lipoprotein cholesterol level (odds ratio per 15 mg/dL, 1.16; 95% confidence interval, 1.01-1.36) and the presence of echolu-cent carotid artery plaque (odds ratio for present vs no plaque, 0.37; 95% confidence interval, 0.18-0.74) in the whole cohort. Interactions of race/ethnicity and early AMD were found for carotid intima-media thickness, increasing severity of maximum carotid artery stenosis, serum triglyceride level, subclinical CVD severity, and Agatston calcium score.Conclusion: Few associations were found between subclinical CVD and CVD risk factors with early AMD. The findings of associations of early AMD with some signs of subclinical atherosclerotic CVD are different among the 4 racial/ethnic groups, which suggests that care must be taken in generalizing from one racial/ethnic group to another.

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Is age-related macular degeneration associated with serum lipoprotein and lipoparticle levels?

Cited by 42 publications

References 37 publications

Transport and Retinal Capture of Lutein and Zeaxanthin with Reference to Age-related Macular Degeneration

Transport and Retinal Capture of Lutein and Zeaxanthin with Reference to Age-related Macular Degeneration

Lipoproteins and Apolipoproteins of the Ageing Eye

Subclinical Atherosclerotic Cardiovascular Disease and Early Age-Related Macular Degeneration in a Multiracial Cohort

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