Is air pollution affecting the disease activity in patients with systemic lupus erythematosus? State of the art and a systematic literature review

Gilcrease, Gregory Winston; Padovan, Darío; Heffler, Enrico; Peano, Cristiana; Massaglia, Stefano; Roccatello, Dario; Radin, Massimo; Cuadrado, María J.; Sciascia, Savino

doi:10.5152/eurjrheum.2019.19141

Cited by 24 publications

(16 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, a low number of cases ( N = 7) in some exposure groups may cause a bias. Another explanation is that particulate matter can have a shielding effect against ultraviolet light [ 45 , 46 ], a well-known risk factor for SLE, which could lead to a marginal protective effect. Future studies adjusting for meteorological variables, including ultraviolet radiation, are needed.…”

Section: Discussionmentioning

confidence: 99%

Association of particulate matter with autoimmune rheumatic diseases among adults in South Korea

et al. 2021

View full text Add to dashboard Cite

Objective The primary objective is to investigate adverse effects of ambient particulate matter (PM) in various size on the incidence of prevalent autoimmune rheumatic diseases (AIRDs): Rheumatoid Arthritis (RA), Ankylosing Spondylitis (AS), and Systemic Lupus Erythematosus (SLE). Methods We investigated 230,034 participants in three metropolitan cities of South Korea from the National Health Insurance Service-National Sample Cohort (NHIS-NSC). Starting from January 2010, subjects were followed up until the first event of prevalent AIRDs, death, or December 2013. 2008-2009 respective averages of PM2.5 (< 2.5μm) and PMcoarse (2.5μm to 10μm) were linked with participants’ administrative district codes. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) were estimated using Cox regression analysis in one- and two-pollutant model. Results Adjusted for age, sex, region, and household income in two-pollutant model, RA incidence was positively associated with 10μg/m³ increment of PM2.5 (aHR = 1.74, 95% CI: 1.06-2.86), but not with PMcoarse (aHR = 1.27, 95% CI: 0.87-1.85). In one-pollutant model, an elevated incidence rate of RA was slightly attenuated (PM2.5 aHR = 1.61, 95% CI: 0.99-2.61; PMcoarse aHR = 1.13, 95% CI: 0.80-1.61), with marginal statistical significance of PM2.5. RA incidence was also higher in 4th quartile group of PM2.5 compared to 1st quartile group (aHR = 1.83, 95% CI: 1.07-3.11). No adverse effects of PM were found on AS or SLE in one- and two-pollutant models. Conclusion Important components of PM10 associated with RA incidence were fine fractions (PM2.5), while no positive association was found between PM and AS or SLE.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of particulate matter with autoimmune rheumatic diseases among adults in South Korea

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Recently, epidemiological evidence suggest that exposure to air pollution could be a potential contributor for SLE activation and aggravation through systemic inflammation and oxidative stress [ 10 , 11 ]. Air pollution is the major environmental risk for health; last reports from the World Health Organization (WHO) showed that annually more than 4 million deaths could be associated with exposure to ambient air pollution [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Chronic exposure to PM2.5 aggravates SLE manifestations in lupus-prone mice

et al. 2021

View full text Add to dashboard Cite

Background Air pollution causes negative impacts on health. Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations and multifactorial etiology. Recent studies suggest that air pollution can trigger SLE and induce disease activity. However, this association has not been deeply investigated. Thus, the aim of this study was to evaluate whether exposure to fine particulate matter (PM2.5) exacerbates SLE manifestations, focusing on renal complications, in a lupus-prone animal model. Female NZBWF1 mice were exposed daily to 600 μg/m3 of inhaled concentrated ambient particles (CAP) or filtered air (FA). Survival rate, body weight, weight of organs (kidney, spleen, thymus, liver and heart), blood cell count, proteinuria, kidney stereology, renal histopathology, gene expression and oxidative stress were analyzed. Results Female NZBW mice exposed to CAP showed decreased survival, increased circulating neutrophils, early onset of proteinuria and increased kidney weight with renal cortex enlargement when compared to NZBW mice exposed to FA. Conclusions This work shows that air pollution aggravates some SLE manifestations in lupus-prone mice. These results reinforce the need of reducing air pollutant levels in order to promote a better quality of life for individuals diagnosed with SLE.

show abstract

“…Baseado em estudos epidemiológicos, a associação entre poluição atmosférica e doenças autoimunes é cada vez mais evidente, sendo os mecanismos de inflamação sistêmica e estresse oxidativo importantes para o desencadeamento e agravamento de algumas dessas doenças, dentre elas o LES (Farhat et al, 2011;Gawda et al, 2016;Gilcrease et al, 2020).…”

Section: Poluição Atmosféricaunclassified

“…Recentemente, a poluição atmosférica ambiental tem sido reportada como um potencial fator de risco para o desenvolvimento ou agravamento de LES (Zhao et al, 2019a;Gilcrease et al, 2020). Estudos epidemiológicos realizados em algumas cidades têm evidenciado um aumento da atividade da doença decorrente do aumento da concentração dos poluentes atmosféricos.…”

Section: Poluição Atmosférica Ambiental E Lesunclassified

See 1 more Smart Citation

Avaliação dos efeitos da exposição à poluição atmosférica sobre o desenvolvimento de lúpus eritematoso sistêmico em camundongos NZBWF1

Yariwake¹

View full text Add to dashboard Cite

Veras (Mari) pela orientação, pela confiança, pela atenção e por me fazer crescer muito, muito mesmo, tanto profissionalmente quanto pessoalmente durante esses mais de 4 anos de convivência. Obrigado por proporcionar oportunidades, bolsas, desafios e experiências, me fazendo sair da zona de conforto ao assumir responsabilidades cada vez maiores e ao ajudar com as colaborações do laboratório. Obrigado também pelo congresso do Havaí, a experiência mais desafiadora que você proporcionou para mim. Realmente aprendi e continuo aprendendo muito ao seu lado. À Dra. Sylvia Farhat pela concepção da ideia inicial desse trabalho; por me apresentar à Mari e à linha de pesquisa em poluição atmosférica, pela qual acabei gostando e me interessando bastante; pela orientação e preocupação com o andamento do projeto e por me dar a oportunidade especial de trabalhar com LES. Ao Prof. Niels Câmara pela continuidade do apoio, do incentivo, da cobrança, do reconhecimento e da orientação desde o começo da Iniciação Científica até agora, no final do Mestrado. Obrigado por deixar as portas do Instituto de Ciências Biomédicas abertas, e por continuar abrindo portas e oportunidades. Ao Prof. Paulo Saldiva, pela contribuição com o conhecimento que temos hoje em relação aos efeitos da poluição atmosférica na saúde e por ser uma das principais referências na área. A todos os colegas e ex-colegas do laboratório pelos ensinamentos, amizade, companhia e risadas no laboratório, congressos e bandejões. Com agradecimento especial à Marlise Domenico e à Janaína Torres, que me ensinaram muitas coisas, principalmente no início, à Daiana Lima pelas aventuras nos congressos e à Sarah Benevenuto pelos conselhos e reflexões. Obrigado Iran Neves, Giovanna Costanzo,

show abstract

Is air pollution affecting the disease activity in patients with systemic lupus erythematosus? State of the art and a systematic literature review

Cited by 24 publications

References 30 publications

Association of particulate matter with autoimmune rheumatic diseases among adults in South Korea

Association of particulate matter with autoimmune rheumatic diseases among adults in South Korea

Chronic exposure to PM2.5 aggravates SLE manifestations in lupus-prone mice

Avaliação dos efeitos da exposição à poluição atmosférica sobre o desenvolvimento de lúpus eritematoso sistêmico em camundongos NZBWF1

Contact Info

Product

Resources

About