Is alcohol consumption associated with gastroesophageal reflux disease?

Chen, Shaohua; Wang, Jie-wei; Li, Youming

doi:10.1631/jzus.b1000013

Cited by 20 publications

(13 citation statements)

References 33 publications

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“…Granted that some of the herbs have potentials for phytotherapeutic applications, contaminants like heavy metals and microbes pose dangers of toxicity and infection [46]. Furthermore, alcohol, which is often added to these herbal medicines has been shown to predispose to reflux by direct toxicity to esophageal mucosa and relaxation of the lower esophageal sphincter [47,48]. Other problems associated with these herbs include inadequate knowledge of their mechanisms of action, possible adverse reactions, contraindications and interactions with other orthodox pharmaceutical products.…”

Section: Discussionmentioning

confidence: 99%

Gastroesophageal reflux disease in a typical African population: a symptom-based multicenter study

et al. 2020

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Background: The prevalence of gastroesophageal reflux disease (GERD) in Africa is not known but is believed to be increasing because of demographic and epidemiologic transition. The main objectives of this study were to determine the prevalence and risk factors of GERD, and its degree of overlap with dyspepsia and irritable bowel syndrome (IBS) in Nigeria, a typical African population. Methods: This was an observational, cross-sectional and descriptive study of adult Nigerians. Diagnosis of GERD was by means of the gastroesophageal reflux disease questionnaire (GERDQ) while the diagnosis of dyspepsia and IBS was based on the Rome III criteria for the diagnosis of functional gastrointestinal disorders. The GERDQ and Rome III questionnaires for dyspepsia and IBS were merged into a composite questionnaire and administered to the study participants who were recruited with a multi-stage sampling technique. Results: Out of 3520 subjects who participated in the study across the country, 269 (7.6%) satisfied the diagnostic criteria for GERD, while 107 (3.0%) had GERD associated with significant impairment of quality of life. Risk factors of GERD (represented by odds ratios) were age 1.014(95% CI: 1.006-1.022), use of analgesics 1.461 (95% CI: 1.060-2.025), and use of herbs 1.318 (95% CI: 1.020-1.704). Overlap of GERD with dyspepsia and/or IBS was observed in over 50% of cases. Conclusions: The prevalence of GERD in this study is 7.6%. Age, use of analgesics and use of herbs increase the risk, albeit minimally. A high degree of overlap with dyspepsia and IBS exists in Nigerian patients with GERD.

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Section: Discussionmentioning

confidence: 99%

Gastroesophageal reflux disease in a typical African population: a symptom-based multicenter study

et al. 2020

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“…The clinical histories for all participants, which included body mass index (BMI), the existence of alcohol and tobacco use, and bruxism, were retrospectively collected to identify behavioural habits [ 18 – 21 , 24 ].…”

Section: Methodsmentioning

confidence: 99%

“…This retrospective clinical study aimed to evaluate the prevalence of OSTDs in GERD patients in the context of salivary flow volume and swallowing function, to test the above hypothesis. Other general association factors for GERD, including body mass index (BMI), alcohol and tobacco use were also investigated [ 18 – 21 ].…”

Section: Introductionmentioning

confidence: 99%

Oral soft tissue disorders are associated with gastroesophageal reflux disease: retrospective study

et al. 2017

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BackgroundDental erosion (DE), one of oral hard tissue diseases, is one of the extraoesophageal symptoms defined as the Montreal Definition and Classification of gastroesophageal reflux disease (GERD). However, no study evaluated the relationship between GERD and oral soft tissues. We hypothesized that oral soft tissue disorders (OSTDs) would be related to GERD. The study aimed to investigate the association OSTDs and GERD.MethodsGERD patients (105 cases), older and younger controls (25 cases each) were retrospectively examined for oral symptoms, salivary flow volume (Saxon test), swallowing function (repetitive saliva swallowing test [RSST]), teeth (decayed, missing, and filled [DMF] indices), and soft tissues (as evaluation of OSTDs, gingivitis; papillary, marginal, and attached [PMA] gingival indexes, simplified oral hygiene indices [OHI-S], and inflammatory oral mucosal regions). Clinical histories, which included body mass index [BMI], the existence of alcohol and tobacco use, and bruxism, were also investigated. A P value of <0.05 was defined as statistically significant.ResultsGERD patients, older and younger controls participated and aged 66.4 ± 13.0, 68.3 ± 8.2 and 28.7 ± 2.6 years old, respectively. The most common oral symptom in the GERD patients was oral dryness. Salivary flow volume and swallowing function in the GERD patients were significantly lower than in either of the controls (all P < 0.05). Inflammatory oral mucosal regions were found only in the GERD patients. The DMF indices, as a measure of dental caries, in the GERD patients were higher than in the younger controls (P < 0.001), but lower than in the older controls (P = 0.033). The PMA gingival indexes, as a measurement for gingival inflammation, and OHI-S, as a measure for oral hygiene, in the GERD patients were significantly higher than in either of the controls (all P < 0.05). Though no significant differences in BMI, the existence of alcohol and tobacco use were found, bruxism, as an exacerbation factor of periodontal disease, in the GERD patients was significantly more frequent than in either control group (P = 0.041).ConclusionsOSTDs were associated with GERD, which was similar to the association between DE and GERD.

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“…Multivariate analysis also identified alcohol use and a history of H. pylori eradication as negative predictors for resolution of GERD symptoms. First, alcohol directly damages esophageal mucosa and influences the function of esophagus and stomach [26]. Alcohol‐induced dysmotility and dysfunction of lower esophageal sphincter may diminish the therapeutic effect of acid suppression drugs.…”

Section: Discussionmentioning

confidence: 99%

Vonoprazan treatment improves gastrointestinal symptoms in patients with gastroesophageal reflux disease

Shinozaki

Osawa

Hayashi

et al. 2017

The Kaohsiung J of Med Scie

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The effects of vonoprazan, a new potassium-competitive acid blocker, on gastroesophageal reflux disease (GERD) symptom are not fully elucidated. The aim of this study is to determine the effect of vonoprazan on GERD and associated gastrointestinal symptoms. We retrospectively reviewed 88 Helicobacter pylori negative patients with GERD treated with vonoprazan 10 mg daily. Symptoms were evaluated using the Izumo scale, which reflects quality of life related to various abdominal symptoms. The rates of improvement and resolution of GERD symptoms were 86% (76/88) and 57% (50/88), respectively. Improvement and resolution in patients with erosive esophagitis was higher than in those with non-erosive reflux disease (91% vs 83%, p = 0.260 and 71% vs 47%, p = 0.025, respectively). We attempted to identify factors which predict the effects of vonoprazan. Multivariate analysis identified advanced age (≥60-year-old) (odds ratio [OR] 7.281, 95% confidence interval [CI] 2.056-25.776, p = 0.002), obesity (BMI ≥ 24) (OR 3.342, 95%CI 1.124-9.940, p = 0.030) and erosive esophagitis (OR 4.368, 95%CI 1.281-14.895, p = 0.018) as positive predictors of resolution of GERD symptoms. Alcohol use (OR 0.131, 95%CI 0.027-0.632, p = 0.011) and history of H. pylori eradication (OR 0.171, 95%CI 0.041-0.718, p = 0.015) were identified as negative predictors. Vonoprazan also improved epigastric pain (73%), postprandial distress (60%), constipation (58%) and diarrhea (52%) in patients with GERD. In conclusion, vonoprazan 10 mg daily is effective in improving GERD symptoms. Advanced age, obesity, erosive esophagitis, alcohol use and history of H. pylori eradication influence the resolution of GERD symptoms. Treatment with vonoprazan favorably affects gastrointestinal symptoms in patients with GERD.

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Is alcohol consumption associated with gastroesophageal reflux disease?

Cited by 20 publications

References 33 publications

Gastroesophageal reflux disease in a typical African population: a symptom-based multicenter study

Gastroesophageal reflux disease in a typical African population: a symptom-based multicenter study

Oral soft tissue disorders are associated with gastroesophageal reflux disease: retrospective study

Vonoprazan treatment improves gastrointestinal symptoms in patients with gastroesophageal reflux disease

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