Is Amygdalin Outcomes Weighing Detriments of Sorafenib Treatment In Female Mice With Kidney Injury Induced By Ehrlich Ascites Carcinoma Model? Preliminary study

Ali, Radi; El-Tantawi, Hala Galal; Rizk, Mohammed El-Sayed; El‐Naggar, Sabry A.; Elmetwalli, Alaa; Salama, Afrah F.

doi:10.21608/blj.2021.194378

Cited by 7 publications

(7 citation statements)

References 5 publications

(5 reference statements)

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“…Given the restricted range of therapeutic interventions, using dietary phytochemicals in the first phases of cancer development is the most secure approach to cancer prevention now [ 6 , 7 ]. Previous studies have provided evidence to support the notion that 6-Gingerol (Gin), a primary pungent constituent found in ginger, has a diverse range of pharmacological characteristics, notably including antioxidative and anti-inflammatory attributes [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Gingerol and/or sorafenib attenuates the DAB-induced HCC and hepatic portal vein dilatation via ATG4/CASP3 and COIIV/COX-2/NF-κB expression

Salama,

El-Far,

Anbar

et al. 2024

Med Oncol

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Ginger (Gin) has numerous therapeutic properties. One of Gin’s most potent components is 6-gingerol, a naturally occurring phenol. This study aimed to investigate the therapeutic impact of gingerol and/or sorafenib on the ATG4/CASP3 and COIIV/COX-2/NF-B Expression as a potential therapy for DAB-induced HCC. Gin was administered to HCC mice induced by p-Dimethylaminoazobenzene (DAB) alone or combined with sorafenib (Sor). Superoxide dismutase (SOD), catalase (CAT), and oxidative stress malondialdehyde (MDA), as well as biochemical markers including AST, ALT, ALP, Albumin, and Bilirubin, were examined. The expression of oncogenes (COIIV, COX-2, NF-κB, and survivin) and tumor suppressor genes (ATG4 and CASP3) was evaluated using qPCR. According to the results, the levels of MDA have been markedly decreased, while SOD and CAT have been increased. Further, the expression levels of tumor suppressor genes were upregulated, whereas the expression levels of oncogene genes were downregulated. Furthermore, in a dose-dependent manner, gingerol has shown the potential to alleviate hepatic portal vein (PV) dilatation and could offer a reliable therapy for HCC. This suggests combining the two compounds may be more effective than alone and that Gin could be a promising therapeutic option for HCC. The binding of Gin and Sor to the active sites of the target genes prevents them from functioning normally, which in turn stops the pathways from carrying out their oncogenic functions. Additionally, COX-2 inhibition reduces the production of certain pro-inflammatory compounds, which further averts oncogenesis. Conclusively, this study indicated that Gin has cytoprotective properties and anti-cancer activity that may be related to controlling oxidative stress. This effect may be achieved by suppressing the COIIV/COX-2/NF-κB pathway and upregulating the ATG4 /CASP3 pathways. Graphical abstract

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Section: Introductionmentioning

confidence: 99%

Gingerol and/or sorafenib attenuates the DAB-induced HCC and hepatic portal vein dilatation via ATG4/CASP3 and COIIV/COX-2/NF-κB expression

Salama,

El-Far,

Anbar

et al. 2024

Med Oncol

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“…Then, using an optical microscope (AX80, Olympus, Tokyo, Japan), HEstained tissue slices were examined and photographed. Microscopic observations included evaluations of tissue architectural abnormalities and tissue structures exhibiting degeneration, necrosis, inflammation, and portal fibrosis [18], [19].…”

Section: Liver Histopathology Evaluationmentioning

confidence: 99%

Assessment of Histological Damage to Rat Liver Induced by Gold Nanoparticles Derived from Bacteria: Preliminary Investigation on Dose-Dependent Effects

G. Abd Elnasser,

Elmetwalli,

A. Hamed

et al. 2024

Benha Journal of Applied Sciences

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Background: Gold nanoparticles (GNPs) have garnered considerable attention in various biomedical applications due to their unique physicochemical properties. Understanding the dose-dependent histological effects of GNPs on liver tissue in animal models is crucial for evaluating their safety profile and optimizing their therapeutic applications. This study aimed to evaluate the hepatotoxicity of bacterially derived GNP on rat liver for proceeding into a further study. Material and Methods: Male Wistar rats were divided into four groups: control, 25, 50, 100, and 200 mg/kg GNP, and the rats were given a 15-day acclimatization period. The rats were subjected to lipid peroxidation, oxidative stress, and liver histology tests. Results: The levels of ALT, AST, and albumin significantly differed from the control group (P<0.001), as revealed in Fig. 1. The results revealed that the rats treated with 50 mg/Kg GNPs had the most beneficial effects, while GSH levels were higher in the group treated with 100 mg/GNPs than in the groups treated with 20 mg/L GNPs. In addition, GNPs-treated rats showed an increase in inflammation in the liver, with the presence of inflammatory cells. Conclusion: These findings emphasize the importance of thorough safety evaluations in GNPs for proceeding the coming research.

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“…The serum samples were used to measure liver function indicators such as GGT and alkaline phosphatase (ALK). Serum indicators were measured using commercial kits in accordance with the manufacturer's recommendations [9], [17].…”

Section: Analysis Of Liver Function Markersmentioning

confidence: 99%

Chitosan-doped gold nanoparticles with potent and selective activity against diabetes mellitus

.Elmetwalli,

. G. Hassan,

Ashraf

et al. 2024

Benha Journal of Applied Sciences

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Background: Diabetes Mellitus (DM) poses a significant global health challenge, with rising prevalence and associated complications. Despite available treatments, the search for safer and more effective options continues. This study investigates the potential of chitosan-doped gold nanoparticles (AuNPs-chito) as a novel therapeutic approach for DM. Chitosan shows promise as a flexible biomolecule for the management of several pathophysiological problems linked to diabetes mellitus (DM) because of its dual roles as an antidiabetic agent and medication carrierMethods: Streptozotocin-induced diabetic rats were treated with AuNPs-chito, and various biochemical and histopathological parameters were assessed.Results: Our data indicate that AuNPs-Chito administration led to significant improvements in blood glucose levels, lipid profiles, oxidative stress markers, and liver function compared to untreated diabetic rats. Histopathological examination revealed restoration of hepatic architecture in AuNPs-chito-treated rats. Conclusion: These findings suggest that AuNPs-chito may offer a promising strategy for managing DM by mitigating oxidative stress and improving metabolic parameters.

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Is Amygdalin Outcomes Weighing Detriments of Sorafenib Treatment In Female Mice With Kidney Injury Induced By Ehrlich Ascites Carcinoma Model? Preliminary study

Abstract: kidney toxicity rather than the undesirable effect of SOR in the tested parameters.

Cited by 7 publications

References 5 publications

Gingerol and/or sorafenib attenuates the DAB-induced HCC and hepatic portal vein dilatation via ATG4/CASP3 and COIIV/COX-2/NF-κB expression

Gingerol and/or sorafenib attenuates the DAB-induced HCC and hepatic portal vein dilatation via ATG4/CASP3 and COIIV/COX-2/NF-κB expression

Assessment of Histological Damage to Rat Liver Induced by Gold Nanoparticles Derived from Bacteria: Preliminary Investigation on Dose-Dependent Effects

Chitosan-doped gold nanoparticles with potent and selective activity against diabetes mellitus

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