Is an Abbreviated Pediatric Crohn’s Disease Activity Index Better Than the Original?

Shepanski, Melissa A.; Markowitz, Jonathan E.; Mamula, Petar; Hurd, Linda B.; Baldassano, Robert N.

doi:10.1097/00005176-200407000-00014

Cited by 71 publications

(58 citation statements)

References 12 publications

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“…We used the Pediatric Ulcerative Colitis Activity Index (range: 0-85, with 0 indicating no disease and higher scores indicating worse disease) 7 for patients with ulcerative/ indeterminate colitis and the abbreviated Pediatric Crohn's Disease Activity Index (range: 0-70, with 0 indicating no disease) 8 for patients with Crohn disease. For CF, we used the Cystic Fibrosis Clinical Score (range: 10-50, with 10 indicating no disease) 9 .…”

Section: Disease Statusmentioning

confidence: 99%

Preparing Adolescents With Chronic Disease for Transition to Adult Care: A Technology Program

et al. 2014

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WHAT'S KNOWN ON THIS SUBJECT: Adolescents with chronic disease are a diverse population with common needs for transition. Disease-specific interventions have shown promise at improving patient outcomes but with substantial personnel and resource costs. Whether a generic approach across diseases may be useful is unknown. WHAT THIS STUDY ADDS:This study is among the first to evaluate a generic (across disease) approach to transition of adolescents to adult care. The approach demonstrated promise and cost savings due to reduced personnel requirement and use of lowcost technology dissemination methods.abstract BACKGROUND: Adolescents with chronic disease (ACD) must develop independent disease self-management and learn to communicate effectively with their health care team to transition from pediatric to adult-oriented health care systems. Disease-specific interventions have been implemented to aid specific ACD groups through transition. A generic approach might be effective and cost-saving.METHODS: Eighty-one ACD, aged 12 to 20 years, were recruited for a randomized clinical trial evaluating an 8-month transition intervention (MD2Me). MD2Me recipients received a 2-month intensive Web-based and text-delivered disease management and skill-based intervention followed by a 6-month review period. MD2Me recipients also had access to a texting algorithm for disease assessment and health care team contact. The intervention was applicable to adolescents with diverse chronic illnesses. Controls received mailed materials on general health topics. Disease management, health-related self-efficacy, and health assessments were performed at baseline and at 2 and 8 months. Frequency of patient-initiated communications was recorded over the study period. Outcomes were analyzed according to assigned treatment group over time. RESULTS:MD2Me recipients demonstrated significant improvements in performance of disease management tasks, health-related selfefficacy, and patient-initiated communications compared with controls.CONCLUSIONS: Outcomes in ACD improved significantly among recipients of a generic, technology-based intervention. Technology can deliver transition interventions to adolescents with diverse chronic illnesses, and a generic approach offers a cost-effective means of positively influencing transition outcomes. Further research is needed to determine whether improved short-term outcomes translate into an improved transition for ACD.

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Section: Disease Statusmentioning

confidence: 99%

Preparing Adolescents With Chronic Disease for Transition to Adult Care: A Technology Program

et al. 2014

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“…Two groups proposed an abbreviated PCDAI (abbrPCDAI), removing the height, extraintestinal manifestation and the three laboratory items (Appendix A1), Table 1 (see Supporting Information). 9,10 The remaining items of the abbrPCDAI were not reweighted. Recently, a larger study presented a short version of the PCDAI (shPCDAI), excluding items with a low frequency of completion in a patient registry (Appendix B1, Table 1) (see Supporting Information).…”

mentioning

confidence: 99%

Mathematical weighting of the pediatric Crohnʼs disease activity index (PCDAI) and comparison with its other short versions

Turner¹,

Griffiths²,

Walters³

et al. 2012

Inflammatory Bowel Diseases

233

198

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“…Patients with an increased residual volume/total lung capacity (RV/TLC) ratio of >30% or with an Hb-corrected TLCO <75% of predicted were invited for a follow-up assessment after a mean interval of 2.8 ± 2.8 years. Clinical IBD activity in CD was documented by means of the abbreviated Paediatric Crohn's Disease Activity Index (PCDAI), which excludes laboratory variables and growth velocity of the original PCDAI but correlates well with the latter [17]. As no pediatric UC activity score was available at the time of study initiation, the Simple Clinical Colitis Activity Index (SCCAI), which had been developed for adult patients, was used for UC patients [18].…”

Section: Methodsmentioning

confidence: 99%

Pulmonary Function Test Abnormalities in Pediatric Inflammatory Bowel Disease

et al. 2015

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Background: Pulmonary involvement in adult patients with inflammatory bowel disease (IBD) seems more common than previously appreciated. Its prevalence and development over time in pediatric IBD patients are largely unknown. Objectives: The aim was to study lung function including fraction of exhaled nitric oxide (FeNO) and transfer capacity for carbon monoxide (TLCO) in pediatric IBD patients and to describe the longitudinal development in a subset of patients with lung function abnormalities. Methods: Sixty-six measurements were made in 48 IBD patients (30 patients with Crohn's disease and 18 with ulcerative colitis) and 108 matched controls. Patients with abnormal TLCO or elevated residual volume/total lung capacity (RV/TLC) ratios were invited for a follow-up. Statistical comparisons were made by nonparametric tests and ANOVA. Results: TLCO was decreased in IBD patients [median: 88% predicted (interquartile range, IQR, 22) vs. 99% predicted (IQR 19) in controls]. RV/TLC ratios were mildly elevated in patients with ulcerative colitis [32% (IQR 9) vs. 27% (IQR 8) in controls], and maximum expiratory flows at 50 and 25% of vital capacity were mildly reduced in patients with Crohn's disease. FeNO and disease activity did not correlate with lung function abnormalities. Abnormalities did not consistently persist over a median follow-up period of 34 months. Conclusions: This study supports evidence that variable and fluctuating pulmonary involvement also occurs in pediatric IBD patients. Its clinical significance is unclear.

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Is an Abbreviated Pediatric Crohn’s Disease Activity Index Better Than the Original?

Cited by 71 publications

References 12 publications

Preparing Adolescents With Chronic Disease for Transition to Adult Care: A Technology Program

Preparing Adolescents With Chronic Disease for Transition to Adult Care: A Technology Program

Mathematical weighting of the pediatric Crohnʼs disease activity index (PCDAI) and comparison with its other short versions

Pulmonary Function Test Abnormalities in Pediatric Inflammatory Bowel Disease

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