Is androgenetic alopecia a risk for atherosclerosis?

Background: Androgenetic alopecia (AGA) is a common form of patterned hair loss characterized by transformation of terminal hair of the scalp to vellous hair mediated mainly by androgens. Premature androgenetic alopecia can be defined as androgenetic alopecia developing before 35 years of age and presenting with at least stage 2 of Norwood-Hamilton classification. Premature AGA not only adds to psychological stress but is also reported as a risk factor for cardiovascular diseases, metabolic syndrome and carcinoma prostrate. In many subsequent studies, AGA has been shown to be associated with several diseases such as insulin resistance (IR), abnormal serum lipid profiles and obesity.Methods: Various parameters of metabolic syndrome were measured in 75 male patients of AGA in the department of dermatology, Safdarjung hospital from June 2015 to April 2016. ECG and echocardiography was done in all patients to look for any evidence of premature coronary artery disease.Results: In our study grade III and IV of AGA were the most common types (32% each). We found the prevalence of metabolic syndrome to be 8% in our patients with premature androgenetic alopecia in accordance with the NCEP ATP III guidelines. There was a significant positive correlation between grade of androgenetic alopecia and metabolic syndorme in our patients (p=0.049). Conclusions: The prevalence of metabolic syndrome was not increased as compared to general population.

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“…26 These findings were similar in our study where we did not detect premature CAD in any of our patients.…”

Section: Premature Coronary Artery Diseasesupporting

confidence: 80%

A study of the association of premature androgenetic alopecia with metabolic syndrome and coronary artery disease

2017

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“…9,11 Association with diseases proposed as being involved in the etiology of AGA, such as benign prostatic hyperplasia, prostate cancer, atherosclerosis, acne vulgaris, and testicular germ cell tumor, has been investigated in various studies, and it has been reported that AGA may be an early marker of these diseases. 9,10,[12][13][14] However, whether or not there is a correlation between AGA and urinary system stone disease, in whose etiology androgens have been shown to be involved, has not been investigated to date. In this study, we investigated whether patients with AGA were at risk in terms of urinary system stone disease.…”

Section: Introductionmentioning

confidence: 99%

“…8,9 Patients typically present with progressive hair thinning in the area affected, followed by hair loss. 10 The disorder affects nearly 50% of men in their lifetimes, and is more common in men with specific polymorphisms in their androgen receptor genes. 9,11 Association with diseases proposed as being involved in the etiology of AGA, such as benign prostatic hyperplasia, prostate cancer, atherosclerosis, acne vulgaris, and testicular germ cell tumor, has been investigated in various studies, and it has been reported that AGA may be an early marker of these diseases.…”

Section: Introductionmentioning

confidence: 99%

The association of urolithiasis and androgenetic alopecia

et al. 2015

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Objectives: The objective of this study is to investigate whether patients with androgenetic alopecia were at risk in terms of urinary system stone disease. Patients and methods: Patients with no baldness (Hamilton-Norwood Scala [HNS] stage I) were categorized as Group I, those with hair loss in the frontal region (HNS stages II, III, IIIa, and IVa) as Group II, those with hair loss in the vertex region (HNS stage III-vertex, V) as Group III and those with hair loss in both vertex and frontal regions (HNS stages IV, Va, VI, and VII) as Group IV. Patients in all groups were compared in terms of presence of stone, and the presence of any association between alopecia and urolithiasis, with common etiological risk factors, was investigated. Results: Three hundred and two male patients were included in the study. The presence of urolithiasis was detected in 28.9% of patients in Group I; 26.5% of Group II; 36.9% of Group III; and 44.4% of Group IV (p ¼ 0.085). Among patients aged under 60, urinary stone disease was detected in 30.8% of patients in Group I; 26.4% of Group II; 41.2% of Group III; and 53.8% of Group IV (p ¼ 0.001). In patients aged over 60, urolithiasis was detected in 12.5% of patients in Group I; 26.9% of Group II; 32.2% of Group III; and 37.8% of Group IV (p ¼ 0.371). Conclusions: We determined a significant correlation between vertex pattern and total alopecia with urolithiasis in patients younger than 60 years old.

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“…Such relationship has been surveyed in many studies in which some studies approved the relationship [12][13][14][15], but the other did not [16][17][18][19]. So, according to these different paradoxical results, in this study, carotid IMT was studied in patients with androgenetic alopecia in comparison to the controls.…”

Section: Introductionmentioning

confidence: 99%