Is anticoagulation required in plasmapheresis? A University Hospital Experience in Bogota, Colombia

Membrane therapeutic plasma exchange with and without heparin anticoagulation

“…The number of apheresis procedures performed each year worldwide with UH is not negligible; however, there are surprisingly few studies about its complications and outcomes. Reports about apheresis or TPE without the use of anticoagulation or with the use of LMWH are even scarcer . Our study is the first to describe treatment and compare complications of a large number of TPE procedures performed with UH, with LMWH, and without anticoagulation.…”

“…When necessary, TPE can be performed without an anticoagulant by periodically flushing the bloodlines and filter with ∼500 mL saline. However, there are only a few studies on the usage of LMWH or saline flushing in TPE, and there are no recommendations . In the present study, we retrospectively analyzed our database to evaluate the safety of different types of heparin anticoagulation in TPE.…”

Therapeutic plasma exchange: Experience in a third level hospital, 2013–2016, Lima (Peru)

“…A number of TPE studies done in Latin America are based on procedures performed using centrifugal apheresis and done by hematology teams, like in our case, but it is interesting to note that in other institutions some nephrologists have performed TPE using membrane filtration devices without circuit anticoagulation. [15][16][17] Perhaps the most wellknown author publishing about membrane filtration TPE without using any type of anticoagulation is Juan Pablo Cordoba MD from Bogota DC, Colombia. [15][16][17] There are some remarkable differences between Dr. Cordoba's study and ours that we will discuss later.…”

“…[15][16][17] Perhaps the most wellknown author publishing about membrane filtration TPE without using any type of anticoagulation is Juan Pablo Cordoba MD from Bogota DC, Colombia. [15][16][17] There are some remarkable differences between Dr. Cordoba's study and ours that we will discuss later.…”

Double filtration plasmapheresis in the treatment of pancreatitis due to severe hypertriglyceridemia

“…Although there is lack of experience, some observational studies support this practice. 15 Although further studies evaluating its clinical efficacy and the absence of negative effects are needed, plasmapheresis has proven effective in achieving significant reductions in TG levels, with a low profile of adverse effects. However, apheresis is an expensive option that is not universally available.…”