2015
DOI: 10.4172/2157-7595.1000216
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Is Aquatic Physical Therapy a Feasible Treatment for Musculoskeletal Dysfunction of Sickle Cell Disease Patients?

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“…Another study performed in patients with SCD who received gene therapy with the use of lentiviral gene addition of an antisickling β-globin variant, showed that normal blood cell counts were attained after the transduced stem cells were engrafted. While adverse events related to the BB305-transduced cells were not observed, and the pattern of vector integration remained polyclonal without clonal dominance, insertional oncogenesis was reported in clinical gene-transfer studies with gamma retroviral vectors [94,95].…”
mentioning
confidence: 96%
“…Another study performed in patients with SCD who received gene therapy with the use of lentiviral gene addition of an antisickling β-globin variant, showed that normal blood cell counts were attained after the transduced stem cells were engrafted. While adverse events related to the BB305-transduced cells were not observed, and the pattern of vector integration remained polyclonal without clonal dominance, insertional oncogenesis was reported in clinical gene-transfer studies with gamma retroviral vectors [94,95].…”
mentioning
confidence: 96%