Is aripiprazole the only choice of treatment of the patients who developed                 anti-psychotic agents-induced leucopenia and neutropenia? A case report

Yalçin, Demet; Göka, Erol; Aydemir, Makbule Çiğdem; Kısa, Cebrail

doi:10.1177/0269881107081559

Cited by 17 publications

(8 citation statements)

References 7 publications

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“…There has been no report of neutropenia associated with aripiprazole as a single agent. In addition, some case reports suggested that aripiprazole can be used in the case of antipsychotic-induced neutropenia 5,9. However, it needs to be reconsidered because, similar with our case, aripiprazole-induced neutropenia subsequent to other antipsychotic-induced neutropenia were reported 10…”

Section: Discussionsupporting

confidence: 78%

“…However, neutropenia has also been reported when patients were treated with other second generation antipsychotics such as olanzapine,2 quetiapine,3 risperidone,4 and amisulpride 5. Although the risk of these individual medicines has been documented, it is still not clear whether the risk of neutropenia is further increased when a patient is sequentially treated with different antipsychotics.…”

Section: Introductionmentioning

confidence: 99%

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A Case with Neutropenia Related with the Use of Various Atypical Antipsychotics

Lim

Park

2013

Psychiatry Investig

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Herein, we report here a case of a 21-year-old patient with a conduct disorder, who had neutropenia associated with treatment with 4 different antipsychotics (olanzapine, quetiapine, risperidone, and aripiprazole) on a sequential basis. This case supports the hypothesis that patients who developed antipsychotic-induced neutropenia on one medication are more likely to develop neutropenia when taking other antipsychotics. Based on this finding, we may suggest that the number of white blood cell and neutrophil counts in patients with a history of antipsychotic-induced neutropenia needs to be carefully monitored during antipsychotic treatment.

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Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

A Case with Neutropenia Related with the Use of Various Atypical Antipsychotics

Lim

Park

2013

Psychiatry Investig

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“…Neutropenia (nadir 1.1 L −9 ) brought on by quetiapine (up to 600 mg/d) accompanied by thrombocytopenia (nadir 146 L −9 ) has been described (Shankar, 2007). In a further patient, neutropenia (nadir 1.4 L −9 ) was manifest on day 7 of quetiapine treatment (400 mg/d), and recovered to 2.5 L −9 5 days after stopping the drug (Yalcin et al ., 2008). Subsequent treatment with amisulpride (400 mg/d, 2 d) was accompanied by a neutrophil count of 1.8 L −9 and amisulpride was stopped as well—this seems unlikely to be an effect of this latter drug since (i) exposure was very brief and (ii) amisulpride has hardly ever been implicated as a cause of neutropenia/agranulocytosis.…”

Section: Neutropenia/agranulocytosis With Antipsychotics Other Than Cmentioning

confidence: 99%

Haematological toxicity of clozapine and some other drugs used in psychiatry

Nooijen

Carvalho

Flanagan

2011

Hum. Psychopharmacol. Clin. Exp.

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There remain several difficult areas, including the criteria for clozapine rechallenge. Experience has emphasised (i) the role of appropriate timing of WCC sample collection to ensure that clozapine is not withdrawn unnecessarily and (ii) the success of agents such as filgrastim in promoting rapid production of granulocytes if the situation so demands. On the other hand, the use of lithium to promote a leucocytosis has taken hold without a clear risk: benefit analysis. Be this as it may, should patients decide that they no longer wish to undergo WCC monitoring after 12 months on clozapine, cessation of monitoring is probably preferable to stopping the drug since overall mortality is decreased in patients treated with clozapine.

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“…3 In a German national study, leukocytopenia seems to be mostly induced by clozapine (0.18% patients exposed) and olanzapine/risperidone at lower proportions. 6 The relatively pure dopamine-affinity profile for amisulpride or aripiprazole might be a possible mechanism for lowering the risk of leukocytopenia or neutropenia. 5 It suggests that most second-generation antipsychotics still have the risk for leukocytopenia.…”

Section: Discussionmentioning

confidence: 99%