Is Arterial Stiffness a Determinant of Hypotension?

Rovella, Valentina; Gabriele, Marco; Sali, E; Barnett, Olga; Scuteri, Angelo; Daniele, Nicola Di

doi:10.1007/s40292-020-00388-9

Cited by 3 publications

(3 citation statements)

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“…Since arterial stiffness has been considered a marker of vessel aging and a predictor for cardiovascular diseases and future events [2,27], there is a strong recommendation to include this measure in clinical practice [28], sometimes even for pediatric routine [29]. Although it is not clear if arterial stiffness precedes hypertension or vice versa [30,31], several studies clearly demonstrate that hypertensive individuals have higher PWV [8,15,32,33].…”

Section: Discussionmentioning

confidence: 99%

“…An important predictor of cardiovascular events is arterial stiffness, which is assessed by pulse wave velocity (PWV). It is present in hypertension and has been considered an index of vascular aging [1][2][3][4]. In this sense, the imbalance between collagen and elastin, the rupture of elastic fibers, and alterations in several proteins of the vascular components contribute to increased arterial stiffening [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Physical Training vs. Perindopril Treatment on Arterial Stiffening of Spontaneously Hypertensive Rats: A Proteomic Analysis and Possible Mechanisms

et al. 2023

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(1) Background: Arterial stiffness is an important predictor of cardiovascular events. Perindopril and physical exercise are important in controlling hypertension and arterial stiffness, but the mechanisms are unclear. (2) Methods: Thirty-two spontaneously hypertensive rats (SHR) were evaluated for eight weeks: SHRC (sedentary); SHRP (sedentary treated with perindopril—3 mg/kg) and SHRT (trained). Pulse wave velocity (PWV) analysis was performed, and the aorta was collected for proteomic analysis. (3) Results: Both treatments determined a similar reduction in PWV (−33% for SHRP and −23% for SHRT) vs. SHRC, as well as in BP. Among the altered proteins, the proteomic analysis identified an upregulation of the EH domain-containing 2 (EHD2) protein in the SHRP group, required for nitric oxide-dependent vessel relaxation. The SHRT group showed downregulation of collagen-1 (COL1). Accordingly, SHRP showed an increase (+69%) in the e-NOS protein level and SHRT showed a lower COL1 protein level (−46%) compared with SHRC. (4) Conclusions: Both perindopril and aerobic training reduced arterial stiffness in SHR; however, the results suggest that the mechanisms can be distinct. While treatment with perindopril increased EHD2, a protein involved in vessel relaxation, aerobic training decreased COL1 protein level, an important protein of the extracellular matrix (ECM) that normally enhances vessel rigidity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Physical Training vs. Perindopril Treatment on Arterial Stiffening of Spontaneously Hypertensive Rats: A Proteomic Analysis and Possible Mechanisms

et al. 2023

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“…Среди пациентов, имеющих в анамнезе кардио-и цереброваскулярные события, большее число принимало бета-блокаторы (в основном бисопролол), однако между испытуемыми, отмечающими СЭГ, и без таковых значимых различий не выявлено. В ранее проведенных работах по выявлению транзиторной гипотонии по данным СМАД было установлено, что повышение скорости пульсовой волны является фактором, способствует развитию транзиторной гипотензии [13]. Поскольку скорость пульсовой волны является индикатором сосудистой жесткости, можно предположить, что указанные результаты не противоречат нашим наблюдениям.…”

Section: результатыunclassified

Symptomatic hypotensive episodes in patients with hypertension. Relationship with blood pressure self-monitoring parameters

2021

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Aim. To study the relationship between symptomatic hypotensive episodes (SHEs) and parameters of self-monitoring of blood pressure (SMPB) in patients with hypertension (HTN).Material and methods. A total of 77 patients from 40 to 76 years old with HTN were examined. To identify SHEs, an original questionnaire was used. Patients underwent SMBP in the morning and evening, as well as recorded SHE in the diary. The self-monitoring period lasted 4 weeks. Patients without prior myocardial infarction and/or stroke are conventionally called “uncomplicated” HTN, while with cardiovascular events in history — “complicated” HTN.Results. According to the questionnaire, 48 (62,3%) patients noted SHEs. Uncomplicated HTN was recorded in 19 (51,4%) participants, while complicated one — in 29 (72,5%) (p=0,05). Blood pressure during SHEs was on average higher in patients with complicated HTN than in uncomplicated HTN (103/60 vs 95/60 mm Hg (p=0,05)). With a combination of uncomplicated HTN and SEG, mean systolic blood pressure (SBP) (125,9±10,5 vs 137,9±8,2 mm Hg), evening SBP (125,3±8,1vs 133,3±10,4 mm Hg), maximum SBP (149,8±11,8 vs 161,7±12,1 mm Hg) in the morning, as well as minimum SBP in the evening (101,8±10,8 vs 113,7±9,7 mm Hg) were lower than in patients without SHEs (p<0,05).In complicated HTN, an opposite relationship was observed: patients with SHEs had higher mean SBP (133,49±12,4 vs 118,93±15,3 mm Hg), maximum SBP (162,8±11,6 vs 141,7±12,0 mm Hg), and diastolic blood pressure (DBP) (91,5±5,6 vs 83,5±8,8 mm Hg) in the morning (p<0,05), as well as higher variability of morning (11,8±2,1 vs 8,2±2,7 mm Hg) and evening SBP (11,9±4,2 vs 8,6±3,2 mm Hg) compared with patients without SHEs (p<0,05). There were no significant differences in antihypertensive therapy.Conclusion. More than half of patients with hypertension report SHEs. SHEs in patients without prior myocardial infarction and/or stroke were characterized by lower blood pressure level than in subjects with prior cardiovascular events. Among patients with SHEs without cardiovascular events, the values of morning, evening, and maximum SBP in the morning are lower than in patients without SHEs. In patients with complicated HTN and SHEs, the opposite trend was observed: higher SBP and DBP in the morning, as well as greater variability of morning and evening SBP, in comparison with those without SHEs. These patterns cannot be explained by the antihypertensive drugs taken.

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Characteristics of clinical course and comorbidity formation of arterial hypotension in farmer population

Mamasoliev,

Tursunov,

Nazarova

et al. 2024

BIO Web Conf.

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The criteria for a significant decrease in arterial pressure is considered to be an element of arterial pressure variability or a certain degree of manifestation. Implementation of various forms of epidemiologic research in order to establish the basis for new approaches to early diagnosis of arterial hypotension, to improve the prognosis, and to achieve high efficiency in prevention has become a necessity and a necessity for farmers in the conditions of Uzbekistan. In the regions of Uzbekistan, there is a great need and necessity to solve the problems of arterial hypotension in this approach. The lack of scientific study of this issue, especially among the large population of Uzbekistan engaged in farming, undoubtedly requires science to fill the “gap” in this direction. Keywords: arterial hypotension, cardiovascular diseases (CVD), chronic heart failure, cardiocomorbidity, non-infectious diseases (NID), arterial pressure variability, independent control of arterial pressure (ABMNQ).

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Is Arterial Stiffness a Determinant of Hypotension?

Cited by 3 publications

References 26 publications

Physical Training vs. Perindopril Treatment on Arterial Stiffening of Spontaneously Hypertensive Rats: A Proteomic Analysis and Possible Mechanisms

Physical Training vs. Perindopril Treatment on Arterial Stiffening of Spontaneously Hypertensive Rats: A Proteomic Analysis and Possible Mechanisms

Symptomatic hypotensive episodes in patients with hypertension. Relationship with blood pressure self-monitoring parameters

Characteristics of clinical course and comorbidity formation of arterial hypotension in farmer population

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