Is arterial stiffness predicted by continuous metabolic syndrome score in obese children?

Prochotska, K.; Kovács, László; Vitariusova, Eva; Feber, Janusz

doi:10.1016/j.jash.2015.10.011

Cited by 7 publications

(3 citation statements)

References 37 publications

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“…Similarly to our data calculated using siMS score, specifi c population-derived continuous MS score rises with the number of manifested components of MS (12,13). Moreover, population-derived MS scores show a signifi cant relationship with different markers of cardiometabolic risk, such as those of infl ammation and fi brinolysis, adipokines, adhesion molecules (14) or subclinical atherosclerosis (12,15). Unlike e.g.…”

Section: Discussionsupporting

confidence: 75%

Continuous metabolic syndrome score (siMS) enables quantification of severity of cardiometabolic affliction in individuals not presenting with metabolic syndrome

Šebeková¹,

Šebek²

2018

BLL

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BACKGROUND: Assessment of degree of cardiometabolic affl iction in subjects not presenting with metabolic syndrome (MS) yet, would be helpful in the management of preventive health maintenance. OBJECTIVES: To evaluate continuous metabolic syndrome score (siMS) in estimation of severity of cardiometabolic affl iction in individuals not presenting with MS. METHODS: We analyzed data from 3166 volunteers (56 % females) aged ≥ 16 years. siMS score was calculated as waist/height/0.5 + fasting plasma glucose (FPG)/5.6 + triacylglycerols (TAG)/1.7 + systolic blood pressure (SBP)/130-high-density lipoprotein cholesterol (HDL-C)/1.02 (males) or 1.28 (females). In siMS quintiles, numbers of individuals presenting with 0-to-5 MS components were calculated. MS was considered as the presence of any 3 out of its 5 components. RESULTS: 33 % of participants without MS scored ≥ 4th quintile; 13 % of those free from MS components; 49 % of participants presenting with 1, and 83 % of those displaying 2 MS components. 11 % of individuals presented with MS, all but 1 displayed siMS within the 2 upper quintiles. CONCLUSIONS: Considerable proportion of individuals without MS presented with siMS in range displayed by individuals presenting with MS. SiMS might be useful in estimation of severity of cardiometabolic affl iction prior to manifestation of MS, to identify individuals requiring early intervention to counteract developing pathological processes (Tab. 1, Ref.

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Section: Discussionsupporting

confidence: 75%

Continuous metabolic syndrome score (siMS) enables quantification of severity of cardiometabolic affliction in individuals not presenting with metabolic syndrome

Šebeková¹,

Šebek²

2018

BLL

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“…11,26,27 In the obese population, AASI has been investigated in very few studies and was found to be significantly higher. 12,28 Similarly, the important finding in our study was that AASI increased significantly in obese children compared to matched lean children.…”

Section: Discussionsupporting

confidence: 70%

Ambulatory arterial stiffness index is increased in obese children

Taşdemir¹,

Erginöz²,

Gayret³

et al. 2020

Turk J Pediatr

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Background and objectives. One way to measure arterial stiffness is the ambulatory arterial stiffness index (AASI), which is the relationship between diastolic and systolic ambulatory blood pressure (BP) over 24-hours. Methods. We studied the difference in AASI between obese and lean children. AASI was calculated from 24hour ambulatory blood pressure monitoring in 53 obese children (33 girls) and compared with age-matched 42 healthy subjects (20 girls). Hypertension was defined according to the criteria of the American Heart Association. To evaluate inflammation, the blood level of high-sensitive C-reactive protein was measured. Results. The mean age was 10.6 ± 2.83 years in obese children and 11.3 ± 3.17 years in healthy subjects. Hypertension was determined in three (5.6%) obese children. The median heart rate-SDS, pulse pressure and blood pressure values did not differ between the two groups. The mean AASI was significantly higher in obese children compared to healthy subjects (0.42 ± 0.15 vs. 0.29 ± 0.18, p <0.001). AASI significantly correlated with nighttime SBP-SDS, nighttime SBP-load, systolic and diastolic nocturnal dipping, with no independent predictor. Conclusion. This study confirms that AASI is increased in obese children. AASI calculation is a useful, costeffective, and an easy method to evaluate arterial stiffness. Early detection of increased arterial stiffness can help clinicians come up with preventive measures in the management of patients.

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“…Different variables are used in cMetS as indicators of obesity, lipids, glucose or insulin, BP and other components including smoking or physical activity. Various statistical approaches including principal component analysis, standardized residuals of Z-scores, and centile rankings have been applied because of the differences in variables included in the definition [ 5 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Validity of a continuous metabolic syndrome score as an index for modeling metabolic syndrome in children and adolescents: the CASPIAN-V study

Heshmat

Heidari

Ejtahed

et al. 2017

Diabetol Metab Syndr

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BackgroundThe purpose of the present study was to assess the validity of continuous metabolic syndrome score (cMetS) for predicting metabolic syndrome (MetS) and to determine the cutoff values in a representative sample of Iranian children and adolescents.MethodsThis national study was conducted among 3843 students, aged 7–18 years country during the fifth survey of a national school-based surveillance program. The cMetS was computed by standardizing the residuals of waist circumference, mean arterial blood pressure, high-density lipoprotein cholesterol, triglycerides, and glucose by regressing them according to age and sex and aggregating them. The optimal cut-off points of cMetS for predicting MetS were determined by the receiver operation characteristic (ROC) curve analysis in different gender and age categories.ResultsTotally, 3843 students (52.3% boys) with average age of 12.45 years were assessed. The mean of cMetS increased according to elevating the number of MetS components. The overall cMetS cut-off point was 1.76 (sensitivity 93% and specificity 82%) in total pediatrics. The area under the ROC curve was 94%. The values for boys and girls were 1.79 and 2.72, respectively.ConclusionscMetS performed highly accurate in predicting pediatrics with MetS in all gender and age groups and it appears to be a valid index in children and adolescents.

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Is arterial stiffness predicted by continuous metabolic syndrome score in obese children?

Cited by 7 publications

References 37 publications

Continuous metabolic syndrome score (siMS) enables quantification of severity of cardiometabolic affliction in individuals not presenting with metabolic syndrome

Continuous metabolic syndrome score (siMS) enables quantification of severity of cardiometabolic affliction in individuals not presenting with metabolic syndrome

Ambulatory arterial stiffness index is increased in obese children

Validity of a continuous metabolic syndrome score as an index for modeling metabolic syndrome in children and adolescents: the CASPIAN-V study

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