Is Artificial Reproductive Technology a Risk Factor for Retinopathy of Prematurity Independent of the Generation of Multiple Births?

Barker, Lucy; Bunce, Catey; Husain, Shahid; Adams, Gill

doi:10.5301/ejo.5000832

Cited by 16 publications

(16 citation statements)

References 23 publications

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“…ART multiple birth babies make up a considerable proportion of the ROP screening burden, and their number is likely to increase as ART is increasingly available and utilised [ 15 ]. McKibbin et al were one of the first to investigate the workload imposed by the treatment for infertility on a ROP screening programme.…”

Section: Resultsmentioning

confidence: 99%

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Artificial Reproductive Technology – A Risk Factor for Retinopathy of Prematurity

Trifonova

Slaveykov

Mumdzhiev

et al. 2018

Open Access Maced J Med Sci

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BACKGROUND:Retinopathy of Prematurity (ROP) is a potentially blinding vasoproliferative disease in premature babies. The presentation and course of ROP are determined by a complex interaction of a series of risk factors, including artificial reproductive technology (ART).AIM:To analyse and combine the information relating ART as an independent risk factor for retinopathy of prematurity.METHODS AND MATERIAL:The article is systematic review and meta-analysis using RevMan 5. Pubmed, Scopus and Medline were searched for articles from 1990 to 2018.RESULTS:Studies suggest that ROP is observed more frequently in ART children. They are more likely to be premature and of low birth weight than those conceived naturally. Results vary from just a tendency to a five-fold increase in risk to develop ROP in ART babies. At the same time, they might develop ROP later, and more mature newborns might be affected.CONCLUSION:The data relating ART as a risk factor for ROP is inconclusive, but most studies show at least a tendency. The ART newborns need to be considered as a risk group for ROP and observed with greater suspicion. Even more mature ART newborns might need to be screened in order not to miss any significant pathology.

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Section: Resultsmentioning

confidence: 99%

“…They found no significant difference between the numbers of babies developing ROP in the ART vs non-ART groups. However, the estimated odds of developing ROP were slightly higher in the ART babies [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

Artificial Reproductive Technology – A Risk Factor for Retinopathy of Prematurity

Trifonova

Slaveykov

Mumdzhiev

et al. 2018

Open Access Maced J Med Sci

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“…Although the exact mechanism is not clear, association between assisted reproductive technology (ART) including in vitro fertilization (IVF) and ROP has been studied with conflicting results. 34,67,125,256,259,394 Some studies identified ART as an independent risk factor for ROP, but it is difficult to draw definite conclusions because ART is also associated with factors including low BW, early GA, and multiple births. Two United Kingdom studies suggest that improvements in IVF may have reduced the additional risk of severe ROP.…”

Section: Alternative Risk Factorsmentioning

confidence: 99%

Retinopathy of prematurity: a review of risk factors and their clinical significance

Kim

Port

Swan

et al. 2018

Survey of Ophthalmology

419

337

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Retinopathy of prematurity (ROP) is a retinal vasoproliferative disease that affects premature infants. Despite improvements in neonatal care and management guidelines, ROP remains a leading cause of childhood blindness worldwide. Current screening guidelines are primarily based on two risk factors: birth weight and gestational age; however, many investigators have suggested other risk factors, including maternal factors, prenatal and perinatal factors, demographics, medical interventions, comorbidities of prematurity, nutrition, and genetic factors. We review the existing literature addressing various possible ROP risk factors. Although there have been contradictory reports, and the risk may vary between different populations, understanding ROP risk factors is essential to develop predictive models, to gain insights into pathophysiology of retinal vascular diseases and diseases of prematurity, and to determine future directions in management of and research in ROP.

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“…Previous studies have shown multiple pregnancies to be a risk factor of GDM [14]. However, although twin pregnancies are often associated with high risk of cesarean section, pre-eclampsia, hypoglycemia, retinopathy, preterm birth and low birth weight [15][16][17][18][19][20], GDM in twin pregnancies have shown conflicting associations to these adverse outcomes [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Burden, associated risk factors and adverse outcomes of gestational diabetes mellitus in twin pregnancies in Al Ain, UAE

Al-Kaabi

Almazrouei

Zoubeidi

et al. 2020

BMC Pregnancy Childbirth

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Background Gestational diabetes mellitus (GDM) in singleton pregnancies represent a high-risk scenario. The incidence, associated factors and outcomes of GDM in twin pregnancies is not known in the UAE. Methods This was five years retrospective analysis of hospital records of twin pregnancies in the city of Al Ain, Abu Dhabi, UAE. Relevant data with regards to the pregnancy, maternal and birth outcomes and incidence of GDM was extracted from two major hospitals in the city. Regression models assessed the relationship between socio-demographic and pregnancy-related variables and GDM, and the associations between GDM and maternal and fetal outcomes at birth. Results A total of 404 women and their neonates were part of this study. The study population had a mean age of 30.1 (SD: 5.3), overweight or obese (66.5%) and were majority multiparous (66.6%). High incidence of GDM in twin pregnancies (27.0%). While there were no statistical differences in outcomes of the neonates, GDM mothers were older (OR: 1.09, 95% CI: 1.06–1.4) and heavier (aOR: 1.02, 95% CI: 1.00 -1.04). They were also likely to have had GDM in their previous pregnancies (aOR: 7.37, 95% CI: 2.76–19.73). The prognosis of mothers with twin pregnancies and GDM lead to an independent and increased odds of cesarean section (aOR: 2.34, 95% CI: 1.03–5.30) and hospitalization during pregnancy (aOR: 1.60, 95% CI: 1.16–2.20). Conclusion More than a quarter of women with twin pregnancies were diagnosed with GDM. GDM was associated with some adverse pregnancy outcomes but not fetal outcomes in this population. More studies are needed to further investigate these associations and the management of GDM in twin pregnancies.

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Is Artificial Reproductive Technology a Risk Factor for Retinopathy of Prematurity Independent of the Generation of Multiple Births?

Cited by 16 publications

References 23 publications

Artificial Reproductive Technology – A Risk Factor for Retinopathy of Prematurity

Artificial Reproductive Technology – A Risk Factor for Retinopathy of Prematurity

Retinopathy of prematurity: a review of risk factors and their clinical significance

Burden, associated risk factors and adverse outcomes of gestational diabetes mellitus in twin pregnancies in Al Ain, UAE

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