Is attention‐deficit/hyperactivity disorder associated with illicit substance use disorders in male adolescents? A community‐based case–control study

Szobot, Cláudia Maciel; Rohde, Luis Augusto; Bukstein, Oscar G.; Molina, Brooke S. G.; Martins, Caroline; Ruaro, Pauline; Pechansky, Flávio

doi:10.1111/j.1360-0443.2007.01850.x

Cited by 80 publications

(60 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…From a genetic point of view, provided compiled evidence for common genetic networks underlying a phenotype including the externalizing disorders ADHD, CD, ODD, and substance disorder. However, a community-based case-control study found an association between ADHD and illicit substance use disorders that was not mediated by CD [10]. Yet because the sample consisted of mainly marijuana or marijuana plus cocaine users, the results might not apply to subjects with a different profile of substance abuse or disorders.…”

mentioning

confidence: 81%

“…In this context, there is still no consensus on the question whether the ADHD inattention symptoms or the ADHD hyperactivity/impulsivity symptoms are more predictive of substance problems [7][8][9]. In addition, some studies found a direct association between ADHD and substance abuse [10], while others demonstrated that this relationship disappears when cooccurring conduct disorder (CD) is taken into account [8,11,12]. Flory et al [3] noted that any observed association between ADHD and substance abuse not considering the overlap of ADHD with CD may be spurious.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Externalizing disorders and substance use: empirically derived subtypes in a population-based sample of adults

Rodgers

Müller

Rössler

et al. 2014

Soc Psychiatry Psychiatr Epidemiol

View full text Add to dashboard Cite

Manuscript to be resubmitted to Social Psychiatry and Psychiatric Epidemiology (SPPE)(Attention-deficit/hyperactivity disorder (ADHD), conduct disorder (CD), and oppositional defiant disorder (ODD) are common externalizing disorders of childhood. The common effects of these disorders on substance abuse need further investigation. The current study investigated the joint clusters of childhood/adolescence ADHD, CD, and ODD, and their influence on substance abuse/dependence in a population-based sample of adults. Methods:The data were drawn from the PsyCoLaus study (n=3720) conducted in Lausanne, Switzerland. The populationbased sample included 238 subjects meeting criteria for ADHD/ODD/CD diagnoses before the age of 15. Latent class analyses (LCA) were performed in order to derive comorbidity subtypes, which were subsequently characterized with respect to psychosocial correlates and substance use. Results:The best fit in LCAs was achieved with three latent classes: an ADHD subtype (35.7%); an externalizing multimorbid subtype (33.6%) involving ODD, ADHD, and CD; and a third subtype with CD (30.7%). The CD subtype showed the highest association with substance use. Apart from this, the externalizing multimorbid subtype was also significantly linked to substance use. The ADHD subtype had only elevated frequencies for alcohol dependence in comparison with subjects that had no history of ADHD, ODD, and CD during childhood or adolescence. Finally, important interactions between subtypes and sex were observed with regard to substance use. Conclusions:This study provides evidence showing that subtyping the externalizing disorders, ADHD, ODD and CD, along their comorbidity patterns leads to important differences regarding substance use. This could have implications for the etiology, prevention, and treatment of substance use disorders. Key words: Attention-deficit/hyperactivity disorder, conduct disorder, oppositional defiant disorder, latent class analysis, epidemiologyExternalizing disorders and substance use Rodgers et al. 3 IntroductionAttention deficit hyperactivity disorder (ADHD) is the most common externalizing disorder of childhood, with prevalence rates between 3 and 7.5%, and, with looser definitions, even up to 17% [1]. Subjects with ADHD frequently remain symptomatic into adulthood. This disorder is associated with adverse long-term functional outcomes, such as poor interpersonal relationships and lower educational qualifications, leading to high economic and social burdens [2]. One of the most controversial issues in the research on ADHD is its relation to comorbid disorders such as substance abuse [3]. A recent meta-analysis demonstrated that childhood ADHD was associated with nicotine use in adolescence and with alcohol and drug use disorders in adulthood [4]. These results were confirmed in a large population-based study [5]. Prevalence rates of substance use disorders were shown to be more than two-fold higher than the 8-15% in the general population [6]. In this context, there is still no consensus on th...

show abstract

mentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Externalizing disorders and substance use: empirically derived subtypes in a population-based sample of adults

Rodgers

Müller

Rössler

et al. 2014

Soc Psychiatry Psychiatr Epidemiol

View full text Add to dashboard Cite

show abstract

“…For example, August et al (18) showed that only subjects with comorbid externalizing disorders (n = 82) had significantly higher rates of PSUD and regular tobacco use compared to both ADHD-only (n=27) and healthy control subjects (n=91). While some studies suggest that the increased risk for developing PSUDs that is seen in ADHD could be completely explained by comorbid CD/ODD in this group (for a review, see 19), but other studies could not confirm this (16,20).…”

mentioning

confidence: 98%

Substance use disorders in adolescents with attention deficit hyperactivity disorder: a 4-year follow-up study

Oosterlaan²,

et al. 2013

View full text Add to dashboard Cite

“…For instance, illicit stimulant use has been associated with psychiatric disorders, including attention-deficit/hyperactivity disorder. 37,38 Unfortunately, standardized assessment of psychiatric disorders was not undertaken as part of the At-Risk Youth Study. Similarly, there is increasing recognition of genetic factors that may predispose individuals to addictive disorders and high-risk drug use, 39 and these data were also not available in the present study.…”

Section: Limitationsmentioning

confidence: 99%

Crystal methamphetamine and initiation of injection drug use among street-involved youth in a Canadian setting

Werb

Kerr

Buxton

et al. 2013

CMAJ

View full text Add to dashboard Cite

show abstract

Is attention‐deficit/hyperactivity disorder associated with illicit substance use disorders in male adolescents? A community‐based case–control study

Abstract: Our results suggest an association between ADHD and illicit SUD in Brazilian adolescents that is not mediated by CD. These findings are potentially important from a prevention perspective because treatments are available for ADHD.

Cited by 80 publications

References 55 publications

Externalizing disorders and substance use: empirically derived subtypes in a population-based sample of adults

Externalizing disorders and substance use: empirically derived subtypes in a population-based sample of adults

Substance use disorders in adolescents with attention deficit hyperactivity disorder: a 4-year follow-up study

Crystal methamphetamine and initiation of injection drug use among street-involved youth in a Canadian setting

Contact Info

Product

Resources

About