Is Berlina grandiflora (Leguminosae) toxic in rats?

Toxicological evaluation of ethyl acetate extract of Cylicodiscus gabunensis stem bark (Mimosaceae)

“…CG had a LD 50 of 11 and 14.5 g/kg p.o., respectively in female and male rats but on administration of sub-lethal (0.75-6 g/kg) doses of the ethyl acetate extract, a high mortality rate of 30 and 50% were observed in rats that received 3 and 6 g/kg, respectively. This result was similar to that obtained by Anaigu et al (2004) who revealed that Berlina grandiflora (Leguminosae), with an LD 50 > 2000 mg/kg (p.o) in rats produced a high mortality rate of 50% in rats when it was administered at the sub-lethal dose of 500 mg/kg in sub-acute toxicity. ASL (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase), T.PRO (total protein), T.CHOL (total cholesterol), GLU (glucose), UR (urea) and CR (creatinine).…”

Subchronic oral toxicity evaluation of ethanolic whole plant extract of Eleucine indica on haematological and biochemical indices in Wistar albino rats

“…E. indica extract caused a significant reduction in the activity of ALP which suggests that there was no damage of the plasma membrane. The significant reduction in ALP levels following the administration of the extract also shows that no possible cholestasis occurred at the dose levels tested since a rise in plasma ALP level is usually a characteristic finding in cholestatic liver disease [29]. Excessive as well as insufficient liver enzymes indicate dysfunction of the liver.…”

“…This increase in urea was reflected in the increase in total protein, the liver capacity to produce the metabolite and also the preservation of the liver integrity of extract-treated rats [29]. Almost all creatinine is removed from the body by the kidneys, so levels in the blood are a good indication of how well the filtering units in the kidneys, called glomeruli, are functioning.…”

Preliminary toxicity study of dichloromethane extract of Kielmeyera coriacea stems in mice and rats

“…ALT is located primarily in the cytosol of hepatocytes, and this enzyme is considered a more sensitive marker of hepatocellular damage than AST. AST is an enzyme found in the cytoplasm and mitochondria in different tissues, chiefly in the heart and skeletal muscles, liver, kidneys, pancreas, and erythrocytes (Chaves and Silva, 1998;Aniagu et al, 2004). The increase in AST in the Fischer's test shows no significant difference between groups (n = 10, p > 0.05).…”