Is blood transfusion safe? BDV and neuropsychiatric illness

Anand, Asha

doi:10.1111/j.1601-5215.2010.00473.x

“…It is of special interest that 33.3% of samples from blood donations were silent virus carriers, a finding confirming Australian [29] and German pilot reports [17, 26], thus being quite in contrast to an earlier report [45]. Transfusion issues relating to BDV infection are still awaiting further clarification [46]. …”

Section: Discussionmentioning

confidence: 72%

Borna disease virus (BDV) infection in psychiatric patients and healthy controls in Iran

Mazaheri-Tehrani

¹

,

Maghsoudi

²

,

Shams

³

et al. 2014

Virol J

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BackgroundBorna disease virus (BDV) is an evolutionary old RNA virus, which infects brain and blood cells of humans, their primate ancestors, and other mammals. Human infection has been correlated to mood disorders and schizophrenia, but the impact of BDV on mental-health still remains controversial due to poor methodological and cross-national comparability.MethodThis first report from the Middle East aimed to determine BDV infection prevalence in Iranian acute psychiatric disorder patients and healthy controls through circulating immune complexes (CIC), antibodies (Ab) and antigen (pAg) in blood plasma using a standardized triple enzyme immune assay (EIA). Samples of 314 subjects (114 psychiatric cases, 69 blood donors, and 131 healthy controls) were assayed and data analyzed quantitatively and qualitatively.ResultsCICs revealed a BDV prevalence of one third (29.5%) in healthy Iranian controls (27.5% controls; 33.3% blood donors). In psychiatric patients CIC prevalence was higher than in controls (40.4%) and significantly correlating with bipolar patients exhibiting overt clinical symptoms (p = 0.005, OR = 1.65). CIC values were significantly elevated in bipolar (p = 0.001) and major depressive disorder (p = 0.029) patients as compared to controls, and in females compared to males (p = 0.031).ConclusionThis study supports a similarly high prevalence of subclinical human BDV infections in Iran as reported for central Europe, and provides again an indication for the correlation of BDV infection and mood disorders. Further studies should address the morbidity risk for healthy carriers and those with elevated CIC levels, along with gender disparities.

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“…In animal models, the transfusion/transfer of lymphocytes from brain of BDV-infected to immuno-compromised rats results in clinical symptoms and neuropathology of Borna disease in the recipients (Batra et al, 2003). Thus, the need for blood test for BDV has been suggested to be included during blood donation and transfusion (Alwin Prem Anand, 2010). If the viral component and/or the lymphocyte are sufficient to cause the clinical symptoms and neuropathology in recipients, blood transfusion might result in the same.…”

Section: Blood Transfusion and Bdvmentioning

confidence: 99%

Blood Transfusion in Clinical Practice

Kochhar¹

2012

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“…In animal models, the transfusion/transfer of lymphocytes from brain of BDV-infected to immuno-compromised rats results in clinical symptoms and neuropathology of Borna disease in the recipients (Batra et al, 2003). Thus, the need for blood test for BDV has been suggested to be included during blood donation and transfusion (Alwin Prem Anand, 2010). If the viral component and/or the lymphocyte are sufficient to cause the clinical symptoms and neuropathology in recipients, blood transfusion might result in the same.…”

Section: Blood Transfusion and Bdvmentioning

confidence: 99%