Is calcitonin gene-related peptide a modulator of menopausal vasomotor symptoms?

Oliveira, M. R. de; Lima, William Gustavo; Schettini, Dante Alighieri; Tilelli, Cristiane Queixa; Chaves, Valéria Ernestânia

doi:10.1007/s12020-018-1777-z

Cited by 5 publications

(4 citation statements)

References 131 publications

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“…Hot flushes are experienced as being very brief, in accordance with the short biological plasma half-life of CGRP [10]. In contrast, administration of exogenous human CGRP leads to local reddening for as long as 1-6 hours after administration [24,25].…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Changing levels of sex hormones and calcitonin gene-related peptide (CGRP) during a woman’s life: Implications for the efficacy and safety of novel antimigraine medications

2021

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Changing levels of sex hormones and calcitonin gene-related peptide (CGRP) during a woman’s life: Implications for the efficacy and safety of novel antimigraine medications

2021

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“…Besides rosacea, our local heating protocol insights could impact other flushing disorders, such as postmenopausal hot flashes. Hot flashes have been associated with simultaneous increases in forehead CVC and common fibular skin sympathetic nerve activity (Hubing et al, 2010;Low et al, 2008;Low et al, 2011) and with increased neuropeptide release in response to local temperature changes (Oliveira et al, 2019). Neural mechanisms could include local axon reflex and sensory afferent roles, neither of which has been fully explored.…”

Section: Clinical Implications and Perspectivesmentioning

confidence: 99%

Effect of sensory blockade and rate of sensory stimulation on local heating induced axon reflex response in facial skin

Metzler-Wilson

Wilson

Ausmus

et al. 2021

Autonomic Neuroscience

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“…The neuropeptide calcitonin gene-related peptide (CGRP), which is found predominantly in sensory C and Aδ nerve fibers, has been suggested to be involved in hot flushes (Wyon et al, 2000; Spetz et al, 2001; Oliveira et al, 2018). CGRP is a potent dilator of the microvasculature and enhances cholinergic sweating in rats and possibly also in humans.…”

Section: Introductionmentioning

confidence: 99%

CGRP Is Critical for Hot Flushes in Ovariectomized Mice

et al. 2019

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Hot flushes are common and troublesome symptoms of menopause. The neuropeptide calcitonin gene-related peptide (CGRP) is increased in plasma during hot flushes but it has not been clear if CGRP is causally involved in the mechanism underpinning the flushes. Here, we examined the effect of interventions with CGRP in a mouse model of hot flushes based on flush-like temperature increases triggered by forced physical activity in ovariectomized mice. Compared to normal mice, ovariectomized mice reacted with an exaggerated, flush-like, temperature increase after physical exercise. This increase was completely blocked by the non-peptide CGRP-antagonist MK-8825 (-0.41 degrees Celsius, 95% CI: -0,83 to 0,012, p < 0.0001) at a dose that had no obvious effects on locomotor activity (50 mg/kg). Further, the flush-like temperature increases were strongly attenuated in ovariectomized mice lacking αCGRP due to a genetic modification. Collectively, our findings suggest that CGRP is an important mediator of experimentally induced hot flushes and they identify CGRP antagonists as promising treatment candidates for women and possibly also men with hot flushes.

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Is calcitonin gene-related peptide a modulator of menopausal vasomotor symptoms?

Cited by 5 publications

References 131 publications

Changing levels of sex hormones and calcitonin gene-related peptide (CGRP) during a woman’s life: Implications for the efficacy and safety of novel antimigraine medications

Changing levels of sex hormones and calcitonin gene-related peptide (CGRP) during a woman’s life: Implications for the efficacy and safety of novel antimigraine medications

Effect of sensory blockade and rate of sensory stimulation on local heating induced axon reflex response in facial skin

CGRP Is Critical for Hot Flushes in Ovariectomized Mice

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