Is carcinoma a mesenchymal disease? The role of the stromal microenvironment in carcinogenesis

Hemmings, Chris

doi:10.1097/pat.0b013e328360b600

Cited by 19 publications

(12 citation statements)

References 117 publications

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“…Over the last decades, the role of the tumor stroma in tumor occurrence and progression had been emphasized. Tumor cells change the characteristics of stromal tissues by exchanging cytokines and enzymes with the surrounding stroma (18)(19)(20). This exchange could contribute to a microenvironment beneficial for the initiation, growth, and invasion of tumor (18).…”

Section: Discussionmentioning

confidence: 99%

Tumor-stroma ratio (TSR) in non-small cell lung cancer (NSCLC) patients after lung resection is a prognostic factor for survival

Xi¹,

Wen²,

Zhu³

et al. 2017

J. Thorac. Dis.

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Section: Discussionmentioning

confidence: 99%

Tumor-stroma ratio (TSR) in non-small cell lung cancer (NSCLC) patients after lung resection is a prognostic factor for survival

Xi¹,

Wen²,

Zhu³

et al. 2017

J. Thorac. Dis.

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“…Earlier reports in colorectal cancer have shown an association between tumour budding and the presence of an immature stroma and a high density of stromal myofibroblasts ( Ueno et al , 2004 ). Furthermore, tumour stroma have been implicated to facilitate EMT, one of the features of budded cells ( Masugi et al , 2010 ; Zlobec and Lugli, 2010 ; Koyuncuoglu et al , 2012 ; Lugli et al , 2012 ; Taira et al , 2012 ; Liang et al , 2013 ), and metastasis of tumour cells into normal tissue ( De Wever and Mareel, 2003 ; Hemmings 2013 ). Therefore, the present finding may support an important role of the tumour stroma in facilitating tumour cell de-differentiation and dissemination, perhaps providing suitable energy substrate and reducing the build-up of metabolic waste ( Koukourakis et al , 2006 ).…”

Section: Discussionmentioning

confidence: 99%

The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer

et al. 2015

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Background:Tumour budding has previously been reported to predict survival in several solid organ tumours, including breast; however, whether this is independent of other aspects of the tumour microenvironment is unknown. In the present study, the relationship between tumour budding, the tumour microenvironment and survival was examined in patients with invasive ductal breast cancer.Methods:Patients presenting between 1995 and 1998 were studied (n=474). Using routine pathological sections, tumour budding was measured at the invasive margin and its association with clinicopathological characteristics and cancer-specific survival (CSS) was examined.Results:Tumour budding was associated with several adverse pathological characteristics, including lymph node involvement, lymph vessel invasion (LVI), increased tumour stroma percentage (TSP) and weaker local inflammatory infiltrative. Tumour budding was associated with reduced CSS (hazard ratio (HR) 2.08, 95% confidence interval (CI) 1.14–3.09, P=0.004), independent of nodal status, molecular subtypes, tumour necrosis, CD8+, CD138+, LVI, blood vessel invasion and TSP. Further, tumour budding was independently associated with reduced CSS in node-negative patients (HR 2.63, 95% CI 1.16–5.92, P=0.020) and those who have low TSP (HR 1.98, 95% CI 1.09–3.57, P=0.024) and high-grade local inflammatory infiltrative (HR 2.27, 95% CI 1.35–5.36, P=0.014).Conclusions:Tumour budding was a significant predictor of survival in patients with invasive ductal breast cancer, independent of adverse pathological characteristics and components of tumour microenvironment. The present study further confirms the clinical utility of both tumour and host-based factors of tumour microenvironment.

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“…These observations suggested a potential relationship between SCC development and sclerotherapy, and also promoted us to hypothesize that whether the carcinoma development after sclerotherapy was associated with the increased mesenchymal components, because a plenty of previous studies have indicated the promotive roles of stromal microenvironment during carcinogenesis [13]. …”

Section: Discussionmentioning

confidence: 99%

Unexpected development of tongue squamous cell carcinoma after sclerotherapy for the venous malformation: a unique case report and literature review

et al. 2013

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BackgroundSclerotherapy is a common and effective treatment for venous diseases, including venous malformations (VMs), which are common vascular anomalies in the oral and maxillofacial regions. However, the safety of sclerotherapy has not been fully elucidated. Occasionally, patients who underwent sclerotherapy may present diverse but minor side effects such as erythema, swelling, pain, tenderness, hyperpigmentation, skin ulceration and necrosis.Case presentationHere we report a unique case of a 65-year-old female patient presented with an original VM lesion on the right side of the tongue. Intralesional sclerotherapy and followed surgical resection resulted in major remission of the original lesion, without recurrence during a 3-year follow-up. However, two years later, the patient was again referred to us for a painful mass on the right side of the tongue that gradually enlarged for 1 month. The mass was biopsied under local anesthesia after complete systematic examination, and the result indicated a well-differentiated squamous cell carcinoma (SCC). Then, the patient underwent right neck dissection, extensive resection of the SCC, reconstruction of the defect with forearm flap, microvascular anastomosis, and repair of the forearm defect with free abdomen skin graft.ConclusionTo the best of our knowledge, this is the first study to document the development of oral SCC after sclerotherapy for VM, underscoring the need for long-term follow-up.Virtual slidesThe virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1897394831087742.

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Is carcinoma a mesenchymal disease? The role of the stromal microenvironment in carcinogenesis

Cited by 19 publications

References 117 publications

Tumor-stroma ratio (TSR) in non-small cell lung cancer (NSCLC) patients after lung resection is a prognostic factor for survival

Tumor-stroma ratio (TSR) in non-small cell lung cancer (NSCLC) patients after lung resection is a prognostic factor for survival

The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer

Unexpected development of tongue squamous cell carcinoma after sclerotherapy for the venous malformation: a unique case report and literature review

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