Is cardiorespiratory fitness a determinant of cardiomyopathy in the setting of type 2 diabetes?

Sénéchal, Martin; Ayers, Colby; Szczepaniak, Lidia S.; Gore, M. Odette; See, Raphael; Abdullah, Shuaib; Berry, Jarett D.; McGuire, Darren K.; McGavock, Jonathan

doi:10.1177/1479164114540924

Cited by 5 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Low CRF was associated with increased cardiometabolic risk factor clustering in adolescence and cardiovascular disease–related morbidity in adulthood. 2 , 10 , 84 , 85 The mean V̇o 2peak derived from direct laboratory-based measures for youths with T2D was 20.7 mL/kg/min, a value approximately 45% lower than in controls with a healthy weight and without diabetes. This deficit was largely mediated by excess body weight, as differences with weight-matched controls were approximately 17%.…”

Section: Discussionmentioning

confidence: 89%

Cardiorespiratory Fitness and Physical Activity in Pediatric Diabetes

Steiman De Visser,

Fast,

Brunton

et al. 2024

JAMA Netw Open

View full text Add to dashboard Cite

ImportanceIt is unclear whether cardiorespiratory fitness (CRF) and physical activity are lower among youths with type 1 diabetes (T1D) and type 2 diabetes (T2D) compared with youths without diabetes.ObjectiveTo describe the magnitude, precision, and constancy of the differences in CRF and physical activity among youths with and without diabetes.Data SourcesMEDLINE, Embase, CINAHL, and SPORTDiscus were searched from January 1, 2000, to May 1, 2022, for eligible studies.Study SelectionObservational studies with measures of CRF and physical activity in children and adolescents aged 18 years or younger with T1D or T2D and a control group were included.Data Extraction and SynthesisData extraction was completed by 2 independent reviewers. A random-effects meta-analysis model was used to estimate differences in main outcomes. The pooled effect estimate was measured as standardized mean differences (SMDs) with 95% CIs. The Preferred Reporting Items for Systematic Review and Meta-Analyses guideline was followed.Main Outcomes and MeasuresThe main outcomes were objectively measured CRF obtained from a graded maximal exercise test and subjective or objective measures of physical activity. Subgroup analyses were performed for weight status and measurement type for outcome measures.ResultsOf 7857 unique citations retrieved, 9 studies (755 participants) with measures of CRF and 9 studies (1233 participants) with measures of physical activity for youths with T2D were included; for youths with T1D, 23 studies with measures of CRF (2082 participants) and 36 studies with measures of PA (12 196 participants) were included. Random-effects models revealed that directly measured CRF was lower in youths with T2D (SMD, −1.06; 95% CI, −1.57 to −0.56; I2 = 84%; 9 studies; 755 participants) and in youths with T1D (SMD, −0.39; 95% CI, −0.70 to −0.09; I2 = 89%; 22 studies; 2082 participants) compared with controls. Random-effects models revealed that daily physical activity was marginally lower in youths with T1D (SMD, −0.29; 95% CI, −0.46 to −0.11; I2 = 89%; 31 studies; 12 196 participants) but not different among youths with T2D (SMD, −0.56; 95% CI, −1.28 to 0.16; I2 = 91%; 9 studies; 1233 participants) compared with controls. When analyses were restricted to studies with objective measures, physical activity was significantly lower in youths with T2D (SMD, −0.71; 95% CI, −1.36 to −0.05; I2 = 23%; 3 studies; 332 participants) and T1D (SMD, −0.67; 95% CI, −1.17 to −0.17; I2 = 93%; 12 studies; 1357 participants) compared with controls.Conclusions and RelevanceThese findings suggest that deficits in CRF may be larger and more consistent in youths with T2D compared with youths with T1D, suggesting an increased risk for cardiovascular disease–related morbidity in adolescents with diabetes, particularly among those with T2D. The findings reinforce calls for novel interventions to empower youths living with diabetes to engage in regular physical activity and increase their CRF.

show abstract

Section: Discussionmentioning

confidence: 89%

Cardiorespiratory Fitness and Physical Activity in Pediatric Diabetes

Steiman De Visser,

Fast,

Brunton

et al. 2024

JAMA Netw Open

View full text Add to dashboard Cite

show abstract

“…Low cardiorespiratory fitness is associated with increased cardiometabolic risk factor clustering in adolescence and cardiovascular disease-related morbidity in adulthood 2,10,78,79 . The average VO 2 peak derived from direct lab-based measures for youth with type 2 diabetes was 20.6 ml/kg/min, a value ~50% lower than healthy weight controls without diabetes.…”

Section: Discussionmentioning

confidence: 99%

Cardiorespiratory fitness and physical activity among children and adolescents with diabetes: A Systemic Review and Meta-analysis

Steinman De Visser,

Fast,

Brunton

et al. 2023

Preprint

View full text Add to dashboard Cite

Introduction: It is unclear if cardiorespiratory fitness (CRF) and physical activity (PA) are lower among youth with type 1 (T1D) and type 2 diabetes (T2D) compared to youth without diabetes. The objective of this study was to describe the magnitude, precision and constancy of the differences in CRF and PA between youth with and without diabetes. Methods: We searched MEDLINE, Embase, CINAHL, and SPORTDiscus from 2000 to May 2022 for cross sectional studies of CRF and PA in youth with and without T1D or T2D. The main outcomes were objectively measured CRF obtained from a graded maximal exercise test and subjective or objective measures of PA. Three reviewers independently screened studies for eligibility, extracted data, and assessed studies for bias. Random effects meta-analysis model was used to estimate differences in main outcomes. The pooled effect estimate was measured as standardized mean differences (SMD) with its 95% confidence intervals (95%CI). This study was registered with PROSPERO (CRD42022329303) and followed the PRISMA reporting guideline. Results: Of 7857 unique citations retrieved, we included 9 studies (n = 755 participants) with measures of CRF and 9 studies (n = 1233 participants) with measures of PA for youth with T2D, as well as 23 studies (n = 2082 participants) and 36 studies (n = 12,196 participants) for youth with T1D. Random effects models revealed that directly measured CRF was lower in youth with T2D [SMD = -1.06; 95% CI: -1.57 to -0.56, I2=84%, n=9 studies; n=781 youth] and in youth with T1D compared to controls [SMD = -0.39; 95% CI: -0.70 to -0.09, I2=89%, n=22 studies; n=2082 youth]. Random effects models revealed that daily PA was marginally lower in youth with T1D [SMD= -0.29, 95% CI ?0.46 to -0.11, I2=89%, n=32 studies; n = 12196 youth] but not different among youth with T2D compared to controls [SMD= -0.56, 95% CI ?1.28 to +0.16, I2=91%, n=9 studies; n=1233 youth]. When analyses were restricted to studies with objective measures, PA was significantly lower in youth with T2D [SMD -0.71, 95% CI ?1.36 to -0.05; I2=23%, n=3 studies; n=332 youth] and T1D [SMD -0.67, 95% CI ?1.17 to -0.17; I2=93%; n=12 studies; n=1357 youth] compared to controls. Conclusion: Children and adolescents living with T1D and T2D display lower CRF and objectively measured PA compared to controls without diabetes. Deficits in CRF, but not PA are larger and more consistent in youth with T2D, compared to youth with T1D.

show abstract

“…Type 2 diabetes mellitus (T2DM) is one of the largest public health concerns leading to significant premature mortality and serious economic burden [ 1 , 2 , 3 , 4 ]. Evidence has shown that health-related fitness, such as cardiorespiratory fitness, muscle strength, and body composition, is an independent predictor of reduced quality of life, cardiovascular risks, and mortality among patients with T2DM [ 5 , 6 , 7 , 8 , 9 ]. Epidemiological studies found that patients with T2DM are frequently found to have low cardiorespiratory fitness and impaired muscle mass and strength as well as altered body composition [ 6 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Yoga on Health-Related Fitness among Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Wibowo

Nur’amalia

Nurrahma

et al. 2022

IJERPH

View full text Add to dashboard Cite

Background: There is a need for a type of physical activity that could address the challenging cycle of physical inactivity, impaired health-related fitness, and type 2 diabetes mellitus (T2DM) conditions. Yoga could be one type of exercise to overcome the barriers to adhere to regular physical activity. The current study aimed to systematically review the effect of yoga on health-related fitness, including cardiorespiratory fitness, muscle strength, body composition, balance, and flexibility, among patients with T2DM. Methods: We systematically searched four databases and two registries (Pubmed, Scopus, Cochrane, Embase, WHO-ITCRP, and Clinicaltrials.gov) in September 2021, following a registered protocol on PROSPERO (CRD42022276225). Study inclusion criteria were T2DM patients with or without complication, yoga intervention as a single component or as a complement compared to other kinds of exercise or an inactive control, health-related fitness, and a randomized, controlled trial or quasi-experimental with control group design. The ROBINS-I tool and ROB 2.0 tool were used to assess the risk of bias in the included studies. A vote-counting analysis and meta-analysis computed using random effects’ models were conducted. Results: A total of 10 records from 3 quasi-experimental and 7 randomized, controlled trials with 815 participants in total were included. The meta-analysis favored yoga groups compared to inactive controls in improving muscle strength by 3.42 (95% confidence interval 2.42 to 4.43), repetitions of chair stand test, and improving cardiorespiratory fitness by 6.6% (95% confidence interval 0.4 to 12.8) improvement of baseline forced vital capacity. The quality of evidence for both outcomes was low. Conclusion: Low-quality evidence favored yoga in improving health-related fitness, particularly muscle strength and cardiorespiratory fitness, among patients with T2DM. Funding: All authors in this systematic review received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

show abstract

Is cardiorespiratory fitness a determinant of cardiomyopathy in the setting of type 2 diabetes?

Cited by 5 publications

References 44 publications

Cardiorespiratory Fitness and Physical Activity in Pediatric Diabetes

Cardiorespiratory Fitness and Physical Activity in Pediatric Diabetes

Cardiorespiratory fitness and physical activity among children and adolescents with diabetes: A Systemic Review and Meta-analysis

The Effect of Yoga on Health-Related Fitness among Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About