Is catechol‐O‐methyltransferase gene associated with temporomandibular disorders? A systematic review and meta‐analysis

Brancher, João Armando; Bertoli, Fernanda Mara de Paiva; Michels, Bruna; Lopes-Faturri, Aluhê; Pizzatto, Eduardo; Losso, Estela Maris; Orsi, Juliana Schaia Rocha; Souza, Juliana Feltrin de; Küchler, Érika Calvano; Wambier, Letícia Maíra

doi:10.1111/ipd.12721

Cited by 16 publications

(12 citation statements)

References 21 publications

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“…However, that the HTR3 receptor genes also seem to influence pain sensitivity in TMD is a novel finding. Regarding the other SNPs a few previous studies have reported an association between chronic TMD and genetic variations in SERT and COMT genes as well [10,11,51,52], but these findings could not be replicated in our study.…”

Section: Discussioncontrasting

confidence: 92%

“…In TMD pain, the role of genetic factors has been discussed as an important part of the etiology since several polymorphisms have shown to be associated with a higher or lower risk of TMD [8]. For example, previous studies show associations between TMD and SNPs in the HTR2A (rs9316233) and COMT genes (rs174697) [10][11][12]. Further, in another study the C allele (common genotype) in the HTR2A SNP (rs2770304) was associated with increased risk for sleep bruxism suggesting that serotonin (5-HT) and other neurotransmitters in the central nervous system and their related genes could be involved in the pathogenesis of bruxism [13].…”

Section: Introductionmentioning

confidence: 99%

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Polymorphisms in the HTR2A and HTR3A Genes Contribute to Pain in TMD Myalgia

Jounger

Christidis

Hedenberg-Magnusson

et al. 2021

Front. Oral. Health

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Background: The aim of this study was to investigate if single nucleotide polymorphisms (SNPs) related to monoaminergic neurotransmission, in particular the serotonergic pathway, contribute to pain perception in patients with temporomandibular disorder (TMD) myalgia and if there is a correlation to jaw function as well as psychosocial factors such as stress, anxiety and depression.Materials and Methods: One hundred and seventeen individuals with TMD myalgia were included. A venous blood or saliva sample was taken for genetic analyses and genotyped regarding HTR2A (rs9316233) HTR3A (rs1062613), HTR3B (rs1176744), SERT (5-HTTLPR) and COMT (rs4680). A clinical examination according to Diagnostic Criteria for TMD (DC/TMD) was performed and axis II data (psychosocial factors) were compared between participants with different genotypes for each gene using Kruskall–Wallis test. The characteristic pain intensity (CPI) was tested for correlations to scores for the Perceived Stress Scale, Generalized Anxiety Disorder, and Patient Health Questionnaires using Spearman's rank correlation test with Bonferroni correction for multiple testing. To further explore data factor analysis was performed to identify latent factors associated to the outcome variables.Results: Participants carrying at least one copy of the rare allele of the HTR2A (rs9316233) and HTR3A (rs1062613) had higher CPI compared with the participants with the homozygous common genotype (P = 0.042 and P = 0.024, respectively). Correlation analyses showed several significant positive correlations between CPI on one hand, and self-reported psychosocial distress and jaw function on the other hand for several genotypes that mostly were weak to moderate. The factor analysis identified two latent variables. One was positively correlated to the HTR3B gene, jaw function and self-reported parafunctions, and the other was positively correlated to psychological distress and negatively correlated to SERT.Conclusion: Taken together, the polymorphism rs1062613 in the HTR3A gene contributes to pain intensity in TMD myalgia. This together with positive interactions between pain variables and psychological factors in genotypes strengthens that pain and psychological distress are related. Further research is needed to explore this as well as the influence of gene-to-gene interactions on pain and psychological distress.

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Section: Discussioncontrasting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Polymorphisms in the HTR2A and HTR3A Genes Contribute to Pain in TMD Myalgia

Jounger

Christidis

Hedenberg-Magnusson

et al. 2021

Front. Oral. Health

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“…They reported two polymorphisms rs6269 and rs9332377 to be related to myofascial pain or myofascial pain with painful TMD respectively. 12 COMT is an enzyme which is involved in the catalysis of catecholamines, such as dopamine, epinephrine, and norepinephrine. The forms of COMTs, that is, soluble COMT and membrane bound COMT, are encoded by the gene located at the cytogenetic loci 22q11.21.…”

Section: Discussionmentioning

confidence: 99%

A Computational Data Mining Strategy to Identify the Common Genetic Markers of Temporomandibular Joint Disorders and Osteoarthritis

Priyadharsini

2022

Glob Med Genet

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Statement of Problem Prosthodontic planning in patients with temporomandibular joint disorders (TMDs) is a challenge for the clinicians. Purpose A differential biomarker identification could aid in developing methods for early detection and confirmation of TMD from other related conditions. Materials and Methods The present study identified candidate genes with possible association with TMDs. The observational study delineates genes from three datasets retrieved from DisGeNET database. The convergence of datasets identifies potential genes related to TMDs with associated complication such as osteoarthritis. Gene ontology analysis was also performed to identify the potential pathways associated with the genes belonging to each of the datasets. Results The preliminary analysis revealed vascular endothelial growth factor A (VEGFA), interleukin 1 β (IL1B, and estrogen receptor 1 (ESR1) as the common genes associated with all three phenotypes assessed. The gene ontology analysis revealed functional pathways in which the genes of each dataset were clustered. The chemokine and cytokine signaling pathway, gonadotropin-releasing hormone receptor pathway, cholecystokinin receptors (CCKR) signaling, and tumor growth factor (TGF)-β signaling pathway were the pathways most commonly associated with the phenotypes. The genes CCL2, IL6, and IL1B were found to be the common genes across temporomandibular joint (TMJ) and TMJ + osteoarthritis (TMJ-OA) datasets. Conclusion Analysis through computational approach has revealed IL1B as the crucial candidate gene which could have a strong association with bone disorders. Nevertheless, several immunological pathways have also identified numerous genes showing putative association with TMJ and other related diseases. These genes have to be further validated using experimental approaches to acquire clarity on the mechanisms related to the pathogenesis.

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“…A systematic review from Visscher and Lobbezoo (4) reported that the literature mainly suggests genetic contributions from candidate genes that encode proteins involved in the processing of painful stimuli from the serotonergic and catecholaminergic systems. Another recent systematic review also supported that pain-related gene is involved in TMD (5). Two pain-related candidate genes are Dopamine Receptor D2 (DRD2) and Ankyrin Repeat and Kinase Domain Containing 1 (ANKK1).…”

Section: Introductionmentioning

confidence: 91%

Temporomandibular disorder in construction workers associated with ANKK1 and DRD2 genes

Baratto¹,

Meger

Camargo

et al. 2022

Braz. Dent. J.

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The study aimed to explore the influence of genetic polymorphisms in ANKK1 and DRD2 on the signs and symptoms of temporomandibular disorder (TMD) in construction workers. This cross-sectional study included only male subjects. All construction workers were healthy and over 18 years age. Illiterate workers and functionally illiterate workers were excluded. The diagnosis of TMD was established according to the Research Diagnostic Criteria for TMD (RDC/TMD). Genomic DNA was used to evaluate the genetic polymorphisms ANKK1 (rs1800497) and DRD2 (rs6275; rs6276) using Real-Time PCR. Chi-square or Fisher exact tests were used to evaluate genotypes and allele distribution among the studied phenotypes. The established alpha of this study was 5%. The sample included a total of 115 patients. The age of the patients ranged from 19 to 70 years (mean age 38.2; standard deviation 11.7). Chronic pain (87.7%), disc displacement (38.2%), and joint inflammation (26.9%) were the most frequently observed signs and symptoms. The genetic polymorphism rs6276 in DRD2 was associated with chronic pain (p=0.033). In conclusion, our study suggests that genetic polymorphisms in DRD2 and ANKK1 may influence TMD signs and symptoms in a group of male construction workers.

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Is catechol‐O‐methyltransferase gene associated with temporomandibular disorders? A systematic review and meta‐analysis

Cited by 16 publications

References 21 publications

Polymorphisms in the HTR2A and HTR3A Genes Contribute to Pain in TMD Myalgia

Polymorphisms in the HTR2A and HTR3A Genes Contribute to Pain in TMD Myalgia

A Computational Data Mining Strategy to Identify the Common Genetic Markers of Temporomandibular Joint Disorders and Osteoarthritis

Temporomandibular disorder in construction workers associated with ANKK1 and DRD2 genes

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