Is CCR5-Δ32 Mutation Associated with Diabetic Nephropathy in Type 2 Diabetes?

Arababadi, Mohammad Kazemi; Naghavi, Nima; Hassanshahi, Gholamhossein; Mahmoodi, Mehdi

doi:10.5144/0256-4947.2009.413

Cited by 6 publications

(9 citation statements)

References 7 publications

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“…Our previous findings demonstrated that the CCR5 Δ 32 mutation was not prevalent in either southeast Iranian T2D patients without nephropathy or T2D patients with nephropathy [36]. The control group in our study also carried a very low prevalence of this mutation (0.66 %) [36]. In agreement with our previous results, Kalev and colleagues reported that there was no association between the CCR5 Δ 32 mutation and native Estonian T2D patients [40].…”

Section: The Status Of the Ccr5 δ 32 Mutation In Type 2 Diabetessupporting

confidence: 93%

“…Some studies proposed that CCR5 can be involved in the recruitment of immune cells to the pancreas; hence, it seems that the genetic and epigenetic factors that alter CCR5 expression, including the CCR5 Δ 32 mutation, can be considered as an important risk factor in the pathogenesis of T2D and its complications including nephropathy. Our previous findings demonstrated that the CCR5 Δ 32 mutation was not prevalent in either southeast Iranian T2D patients without nephropathy or T2D patients with nephropathy [36]. The control group in our study also carried a very low prevalence of this mutation (0.66 %) [36].…”

Section: The Status Of the Ccr5 δ 32 Mutation In Type 2 Diabetesmentioning

confidence: 63%

“…It has been well documented that parameters that influence or regulate the immune system can be associated with T2D and its complications [32][33][34][35][36]. Previous studies have revealed that adiponectin can upregulate expression of CCL3, 4, and 5, while downregulating surface CCR5 expression [37].…”

Section: The Status Of the Ccr5 δ 32 Mutation In Type 2 Diabetesmentioning

confidence: 99%

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Is the CCR5 Δ 32 Mutation Associated with Immune System-Related Diseases?

et al. 2012

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Hypersensitivity and autoimmunity are the main features of immune system-related diseases such as type 2 diabetes (T2D), multiple sclerosis (MS), and asthma. It has been established that chemokines play key roles in the activation and regulation of immune cell migration which is important in the pathogenesis of the diseases mentioned. CC chemokines receptor 5 or CCR5 is a receptor for RANTES, MIP-1α, and MIP-1β and is expressed by several immune cells including NK cells, T lymphocytes, and macrophages. It plays key roles in the regulation of migration and activation of the immune cells during immune responses against microbe and self-antigens during autoimmunity and hypersensitivity disorders. Therefore, any alteration in the sequence of CCR5 gene or in its expression could be associated with immune system-related diseases. Previous studies revealed that a 32-base pair deletion (Δ 32) in exon 1 of the CCR5 gene led to downregulation of the gene. Previous studies demonstrated that not only CCR5 expression was altered in autoimmune and hypersensitivity disorders, but also that the mutation is associated with the diseases. This review addresses the recent information regarding the association of the CCR5 Δ 32 mutation in immune-related diseases including T2D with and without nephropathy, MS, and asthma. Based on the collected data, it seems that the CCR5 Δ 32 mutation can be considered as a risk factor for MS, but not asthma and T2D with and without nephropathy.

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Section: The Status Of the Ccr5 δ 32 Mutation In Type 2 Diabetessupporting

confidence: 93%

Section: The Status Of the Ccr5 δ 32 Mutation In Type 2 Diabetesmentioning

confidence: 63%

Section: The Status Of the Ccr5 δ 32 Mutation In Type 2 Diabetesmentioning

confidence: 99%

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Is the CCR5 Δ 32 Mutation Associated with Immune System-Related Diseases?

et al. 2012

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“…In SLE, the inflammatory process is initiated by lymphocytic infiltration into tissue spaces, and the biological distribution of lymphocytes appears to be determined by the expression of chemokines receptors, including CCR5 [35,36]. The deletion of 32 pb of CCR5 leads to a decreased expression and dysfunction of CCR5 protein and could exert a role in the immune system-related diseases [37].…”

Section: Discussionmentioning

confidence: 99%

CCR5Δ32 (rs333) polymorphism is associated with the susceptibility to systemic lupus erythematosus in female Brazilian patients

et al. 2015

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The role of CCR5Δ32 (rs333) polymorphism in the pathogenesis of systemic lupus erythematosus (SLE) has been evaluated worldwide. The aim of this study was to determine the association between CCR5Δ32 polymorphism with the susceptibility to SLE and the activity of disease in female Southern Brazilian patients. The study enrolled 169 female SLE patients and 132 unrelated female healthy individuals. Baseline clinical, laboratorial characteristics, and the SLE activity (determined using the SLEDAI) were evaluated according to the CCR5Δ32 genotypes. The CCR5Δ32 polymorphism was determined from genomic DNA using a polymerase chain reaction. The frequencies of the genotypes CCR5/CCR5, CCR5/CCR5Δ32, and CCR5Δ32/CCR5Δ32 were 87.6, 11.8, and 0.6 %, respectively, among the patients and 96.2, 3.8, and 0.0 %, respectively, among the controls [CCR5/CCR5 vs. CCR5/CCR5Δ32 + CCR5Δ32/CCR5Δ32: p = 0.0081, odds ratio 3.604 (95 % confidence interval 1.321-9.4836)]. The frequencies of the CCR5 and the CCR5Δ32 alleles were 93.2 and 6.8 % among the patients, and 98.1 and 1.9 % among the controls, respectively (p = 0.0047, OR 3.758, 95 % CI 1.409-10.80). Patients carrying the genotypes with the CCR5Δ32 allele presented earlier age of onset of disease (p = 0.0293) and higher levels of anti-dsDNA (p = 0.0255) than those carrying the wild-type genotype. When the analysis was adjusted for ethnicity, only the age at onset of disease remained significant (p > 0.05). The results suggest that the CCR5Δ32 polymorphism might be associated with SLE genetic predisposition among female Brazilian patients and the age at onset of the disease; however, this genetic variant was not associated with the activity of SLE in this population.

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“…The crucial role of cytokine networks in orientating immune responses is well documented [26]. Several factors such as infectious agents, hormonal conditions, and cytokine gene polymorphisms regulate expression and secretion of cytokines [27].…”

Section: Discussionmentioning

confidence: 99%

Interleukin (IL)-10 Gene Polymorphisms Are Associated with Type 2 Diabetes With and Without Nephropathy: A Study of Patients from the Southeast Region of Iran

et al. 2011

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The impact of several environmental and genetic factors on diabetes and its complications is well documented. It has also been established that cytokines play a key role in the regulation of immune responses which have been shown to be important in the pathogenesis of diabetes. Studies showed that single-nucleotide polymorphisms within the -592 region of interleukin-10 (IL-10) are associated with the regulation of its expression. In this study, we aimed to find polymorphisms of this region that may be associated to type 2 diabetic (T2D) patients with and without nephropathy. In this study, peripheral blood samples were collected from 100 T2D patients without nephropathy, 100 T2D patients with nephropathy, and 100 healthy controls. DNA was extracted, and a polymerase chain reaction-restriction fragment length polymorphism technique was performed to examine the polymorphisms within the -592 region of the IL-10 gene. Our results showed a significant difference between the genotypes and alleles of the -592 region of IL-10 in nephropathic and non-nephropathic patients in comparison to the healthy controls. The differences between the two patient groups in relation to genotypes and alleles were not significant. Results of this study suggest that the functional gene polymorphism of IL-10 reported here may play an important role in the pathogenesis of diabetes, but it seems that these polymorphisms do not have an effect on the nephropathic complications of the disease.

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Is CCR5-Δ32 Mutation Associated with Diabetic Nephropathy in Type 2 Diabetes?

Cited by 6 publications

References 7 publications

Is the CCR5 Δ 32 Mutation Associated with Immune System-Related Diseases?

Is the CCR5 Δ 32 Mutation Associated with Immune System-Related Diseases?

CCR5Δ32 (rs333) polymorphism is associated with the susceptibility to systemic lupus erythematosus in female Brazilian patients

Interleukin (IL)-10 Gene Polymorphisms Are Associated with Type 2 Diabetes With and Without Nephropathy: A Study of Patients from the Southeast Region of Iran

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