Is central hyperacusis a symptom of 5-hydroxytryptamine (5-HT) dysfunction?

Marriage, Josephine; Barnes, Nicholas M.

doi:10.1017/s0022215100131676

Cited by 123 publications

(73 citation statements)

References 59 publications

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“…While the higher incidence of sensorineural hearing loss shown in the current study was more associated with nonmigrainous etiologies, noise exposure and age differences between the groups could also partly explain the difference. Given the association of migraine and phonophobia/hyperacusis [Marriage and Barnes, 1995], the migrainous groups may have a lower incidence of noise-induced sensorineural hearing loss, as they are more likely to avoid loud noise. Furthermore, the NMV group is more likely to have a higher incidence of sensorineural loss due to presbyacusis as this group was significantly older.…”

Section: Discussionmentioning

confidence: 99%

Neuro-Otological Findings in Patients with Migraine- and Nonmigraine-Related Dizziness

Vitkovic

Paine²,

Rance³

2007

Audiol Neurotol

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This study presents the neuro-otological findings of 523 patients attending a tertiary vestibular clinic with migraine- and nonmigraine-related dizziness. Subjects were categorized into one of 4 groups, definite migrainous vertigo, probable migrainous vertigo, vestibular disorder coexisting with migraine and nonmigraine-related dizziness. No notable relationship was found between the numbers of abnormal findings between the groups for the majority of the neuro-otological tests. However, there was a significant trend in emetic response to caloric testing. The definite migrainous vertigo group were at least 4 times more likely to be nauseous to caloric testing than any other migraine category. This difference was independent of the magnitude of caloric responses between the emetic migraine groups. While further investigation is required, this study has potentially identified that nauseous/emetic response to caloric stimulation may be a distinguishing factor between migrainous vertigo and other vestibular disorders including those with a coexisting history of migraine.

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Section: Discussionmentioning

confidence: 99%

Neuro-Otological Findings in Patients with Migraine- and Nonmigraine-Related Dizziness

Vitkovic

Paine²,

Rance³

2007

Audiol Neurotol

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“…Serotonin regulates a variety of functions such as cognition, emotion, sleep, appetite, pain, circadian rhythms and endocrine activity [50] . Modifi cations of serotonin neurotransmission impair inhibitory associative learning [51] and have been proposed to contribute to tinnitus [52] and hyperacusis [53] .…”

Section: A Candidate Gene For Some Forms Of Tinnitus?mentioning

confidence: 99%

Tinnitus: Standard of Care, Personality Differences, Genetic Factors

Tyler

Coelho²,

Noble³

2006

ORL

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We comment on three areas related to tinnitus. The standard of care should include counseling that is collaborative and that addresses the overall emotional well-being of the patient. Utilizing management and coping strategies is desirable. Our new tinnitus activities treatment is an example of such a protocol. We believe that the notions of fearfulness and acceptance have the potential to be integrated into tinnitus treatment. Some patients reject, control or accept their tinnitus. We believe in some instances there may be a common genetic cause of tinnitus and depression. A potential candidate is the serotonin transporter gene SLC6A4.

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“…Patients reported that their sound tolerance was influenced by stress and tiredness, and that specific (though not necessarily loud) sounds caused physical pain and nerve grating [8]. Stephens [9] also reported a correlation between loudness tolerance and anxiety.…”

Section: Introductionmentioning

confidence: 99%

Psychometric Normalization of a Hyperacusis Questionnaire

Khalfa

Dubal

Veuillet

et al. 2002

ORL

369

358

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Clinical hyperacusis consists of a marked intolerance to ordinary environmental sounds, while hearing thresholds are quite often normal. Hyperacusis appears to be a subjective phenomenon, which is not easily defined or quantified by objective measurements. In order to create a tool suitable to quantify and evaluate various hyperacusis symptoms, a questionnaire screening several aspects of auditory symptomatology has been constructed. Two hundred and one subjects (who were either hyperacusic or not), randomly selected from the general population, were tested. A principal component analysis performed on the correlation matrix of the 14 items of the questionnaire isolated three dimensions: attentional, social, and emotional. The three dimensions had satisfactory internal consistency reliability. The mean ± SD total score was 15 ± 6.7 out of 42 (maximum of hyperacusis) and a score greater than 28 seems to represent a strong auditory hypersensitivity. This new psychometric tool should further be tested on hyperacusic patients to verify its relevance in pathology and define the involvement of the three dimensions statistically obtained on the hyperacusis symptomatology.

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Is central hyperacusis a symptom of 5-hydroxytryptamine (5-HT) dysfunction?

Cited by 123 publications

References 59 publications

Neuro-Otological Findings in Patients with Migraine- and Nonmigraine-Related Dizziness

Neuro-Otological Findings in Patients with Migraine- and Nonmigraine-Related Dizziness

Tinnitus: Standard of Care, Personality Differences, Genetic Factors

Psychometric Normalization of a Hyperacusis Questionnaire

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