Is cerebral glucose metabolism affected by chemotherapy in patients with Hodgkin’s lymphoma?

Chiaravalloti, Agostino; Pagani, Marco; Pietro, Barbara Di; Danieli, Roberta; Tavolozza, Mario; Travascio, Laura; Caracciolo, Cristiana Ragano; Simonetti, Giovanni; Schillaci, Orazio

doi:10.1097/mnm.0b013e32835aa7de

Cited by 23 publications

(35 citation statements)

References 29 publications

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“…This was also notably shown for the inferior temporal/fusiform gyrus in a study using a VBM procedure [23] as well as for the dorsolateral prefrontal cortex in morphometric studies [28,29].…”

Section: Discussionmentioning

confidence: 87%

“…Certain studies have shown limited effects of cancer or of cancer treatments on brain metabolism [29,30], whereas others have shown more marked impacts [31][32][33]. To minimise this possibly confounding effect, we only selected patients: (1) with a minimal interval time of one month between the last chemotherapy or radiotherapy and the FDG-PET exam and (2) with normal neuropsychological tests including no symptom of depression at MINI test.…”

Section: Discussionmentioning

confidence: 99%

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Age-related changes in FDG brain uptake are more accurately assessed when applying an adaptive template to the SPM method of voxel-based quantitative analysis

Gucht¹,

Verger

Guedj

et al. 2015

Ann Nucl Med

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Age-related changes in FDG brain uptake are more accurately assessed when applying an adaptive template to the SPM method of voxel-based quantitative analysis

Gucht¹,

Verger

Guedj

et al. 2015

Ann Nucl Med

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“…A dysfunction of this network could potentially explain the neurocognitive, behavioural and mood alterations found in some chemotreated cancer survivors [1-3]. Some authors hypothesized that prefrontal dysfunction could be linked to acute depression and posttraumatic stress in those patients that later normalize [44]. However, our patients were not depressed or anxious and were cognitively spared.…”

Section: Discussionmentioning

confidence: 95%

Multivariate analysis of brain metabolism reveals chemotherapy effects on prefrontal cerebellar system when related to dorsal attention network

et al. 2013

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BackgroundFunctional brain changes induced by chemotherapy are still not well characterized. We used a novel approach with a multivariate technique to analyze brain resting state [18 F]FDG-PET in patients with lymphoma, to explore differences on cerebral metabolic glucose rate between chemotherapy-treated and non-treated patients.MethodsPET/CT scan was performed on 28 patients, with 14 treated with systemic chemotherapy. We used a support vector machine (SVM) classification, extracting the mean metabolism from the metabolic patterns, or networks, that discriminate the two groups. We calculated the correct classifications of the two groups using the mean metabolic values extracted by the networks.ResultsThe SVM classification analysis gave clear-cut patterns that discriminate the two groups. The first, hypometabolic network in chemotherapy patients, included mostly prefrontal cortex and cerebellar areas (central executive network, CEN, and salience network, SN); the second, which is equal between groups, included mostly parietal areas and the frontal eye field (dorsal attention network, DAN). The correct classification membership to chemotherapy or not chemotherapy-treated patients, using only one network, was of 50% to 68%; however, when all the networks were used together, it reached 80%.ConclusionsThe evidenced networks were related to attention and executive functions, with CEN and SN more specialized in shifting, inhibition and monitoring, DAN in orienting attention. Only using DAN as a reference point, indicating the global frontal functioning before chemotherapy, we could better classify the subjects. The emerging concept consists in the importance of the investigation of brain intrinsic networks and their relations in chemotherapy cognitive induced changes.

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“…In the first such investigation (15), both 18 F-FDG and 15 O-water brain PET studies were performed on healthy control subjects and breast cancer patients previously treated or untreated by chemotherapy. Altered functioning of the prefrontal cortex and cerebellum in patients previously treated with adjuvant therapy, 5-10 y after their last dose of chemotherapy, was found.…”

Section: Crci: Neuroimagingmentioning

confidence: 99%

Long-Term Clinical and Neuronuclear Imaging Sequelae of Cancer Therapy, Trauma, and Brain Injury

et al. 2019

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Learning Objectives: On successful completion of this activity, participants should be able to (1) describe clinical features and therapeutic approaches in the evaluation and management of cancer-and chemotherapy-related cognitive impairment (CRCI), posttraumatic stress disorder (PTSD), and traumatic brain injury (TBI); (2) discuss the role of neuroimaging in contributing to understanding of relationships between clinical features of CRCI, PTSD, and TBI, with aspects of underlying regional cerebral function; and (3) identify which brain processes are most consistently shown to be affected in CRCI, PTSD, and TBI.

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Is cerebral glucose metabolism affected by chemotherapy in patients with Hodgkin’s lymphoma?

Abstract: Our results support the conclusion of a very limited impact of ABVD chemotherapy on brain metabolism in patients with HD.

Cited by 23 publications

References 29 publications

Age-related changes in FDG brain uptake are more accurately assessed when applying an adaptive template to the SPM method of voxel-based quantitative analysis

Age-related changes in FDG brain uptake are more accurately assessed when applying an adaptive template to the SPM method of voxel-based quantitative analysis

Multivariate analysis of brain metabolism reveals chemotherapy effects on prefrontal cerebellar system when related to dorsal attention network

Long-Term Clinical and Neuronuclear Imaging Sequelae of Cancer Therapy, Trauma, and Brain Injury

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