Is Chlamydia pneumoniae seropositivity associated with atherothrombotic cerebrovascular infarction?

Alavi, Seyed Mohammad; Ahmadi, Fatemeh; abeshtan, Ahmad

doi:10.1016/j.jiph.2009.04.001

Cited by 2 publications

(2 citation statements)

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“…Several studies have found an association between chlamydia pneumonia infection and stroke that infection with Chlamydia pneumonia increases the risk of brain disease, but others have not (11)(12). The difference in these results may be due to the different sample sizes in other studies, the difference in the age of the participants in the current study, or the various detection methods for chlamydia pneumonia infection.…”

Section: Discussionmentioning

confidence: 63%

“…In contrast to these mentioned studies, there are also studies in which it was reported that there is no significant relationship between cerebrovascular infarcts and chlamydia pneumonia infection (11). As a result of the importance of the stated content and conflicting findings, the study was designed to investigate whether Chlamydia pneumonia infection may be associated with non-cardioembolic ischemic strokes.…”

Section: Association Between Infection With Chlamydia Pneumonia and C...mentioning

confidence: 99%

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Association between infection with Chlamydia pneumonia and cerebral noncardioembolic ischemic stroke

Abbas

Masoud

khorshidi

et al. 2022

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Introduction: Stroke is the third most common cause of mortality and the most common disability disorder among adults. We aimed to study the relationship between Chlamydia pneumonia infection and non-cardio Ambulatory ischemic stroke. Methods: This case-control study was performed on 162 patients with non-cardio ambulatory ischemic stroke admitted to Shahid Beheshti Hospital of Kashan in 2019 as the case group and patients with neurological headache and degenerative diseases as the control group. After filling out the questionnaire for all subjects, we took blood samples. We analyzed all three anti-chlamydia pneumonia antibodies (IgM, IgG, IgA) by ELISA method after data were analyzed by Chi-square and Fisher tests. Results: The findings of this study showed that positive IgA in the stroke group was significantly higher than in the control group (p=0.001); it was also found that the risk factors of HTN (p=0.001), HLP (p=0.001), DM (p=0.001), and age (p = 0.049) were significantly higher in the stroke patients' group than the control group. On the other hand, there was not a significant difference in serum IgG level (p = 0.349), IgM (p = 0.745), smoking (p = 0.211) and gender (p = 0.157) in understudied groups. Conclusion: Chlamydia IgA antibodies can be a complementary tool for predicting prognosis and monitoring new therapies for ischemic stroke. This study provides a way for further studies, especially with other markers of acute and chronic systemic Chlamydia pneumonia infection. Antibiotic treatment significantly helps to reduce mortality and stroke complications.

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Section: Discussionmentioning

confidence: 63%

Section: Association Between Infection With Chlamydia Pneumonia and C...mentioning

confidence: 99%

Association between infection with Chlamydia pneumonia and cerebral noncardioembolic ischemic stroke

Abbas

Masoud

khorshidi

et al. 2022

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Chlamydia pneumoniae infection and cerebrovascular disease: a systematic review and meta-analysis

Chen

Zhu

et al. 2013

BMC Neurol

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BackgroundA wealth of published studies have been published on association between Chlamydia pneumoniae (C.pneumoniae) infection and cerebrovascular (CV) disease, but the results were inconsistent. This meta-analysis provides a systematic review of the available evidence from all serological and pathological studies of CV disease and C.pneumoniae.MethodsA comprehensive research was conducted of MEDLINE, EMBASE, CNKI, WanFang technological periodical database and reference lists of articles to identify eligible case-control and cohort studies. Odds radio (OR) was calculated for each study outcome. Random effect model was used as pooling method and publication bias was estimated for the results.ResultsFifty-two published studies that met criteria were selected. In case control studies, an association between C.pneumoniae infection and CV disease was revealed by serum specific IgG (OR, 1.61; 95% CI: 1.34 to 1.94), serum IgA (OR, 2.33; 95% CI: 1.76 to 3.08) and PCR technique of C.pneumoniae in peripheral blood cells (OR, 1.90; 95% CI: 1.17 to 3.07). No significant association was found in serum anti-C.pneumonae IgM seropositivity or in-situ-detection of C.pneumoniae in arterial biopsies with CV disease. Subgroup analysis by available studies suggested that C.pneumoniae may paly a role in atherosclerotic stroke, but be less significant in stroke of cardioembolism or other etiologies.ConclusionAssociation between C.pneumoniae infection and CV disease depends on the analytical method adopted, which seems stronger with stroke due to large artery atherosclerosis. Establishing a causal relationship between C.peumoniae infection and CV disease will require more prospective studies with combination of techniques and stratified by etiological subtypes.

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Is Chlamydia pneumoniae seropositivity associated with atherothrombotic cerebrovascular infarction?

Abstract: Our finding suggests that there is no association between ACI and positive CP-IgG in Iranian patients.

Cited by 2 publications

References 15 publications

Association between infection with Chlamydia pneumonia and cerebral noncardioembolic ischemic stroke

Association between infection with Chlamydia pneumonia and cerebral noncardioembolic ischemic stroke

Chlamydia pneumoniae infection and cerebrovascular disease: a systematic review and meta-analysis

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