2010
DOI: 10.4314/ajid.v4i2.55145
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Is Chloroquine better than Artemisinin combination therapy as first line treatment in adult Nigerians with uncomplicated malaria? a cost effective analysis

Abstract: The current case management and drug policy of malaria in Nigeria recommended by the Federal ministry of health may not be appropriate for all age categories. This suspicion was tested by running a cost effectiveness analysis of two possible and alternative strategies: Artemisinin Combination Therapy (ACT) or Chloroquine and ACT only if CQ fails (CANACT), in adult non pregnant Nigerians aged 20–45yrs. The result confirms that ACT is indeed more effective but also more costly with an incremental cost effectiven… Show more

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Cited by 5 publications
(3 citation statements)
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“…-for the prevention and treatment of malaria (Mengesha and Makonnen, 1999;Bello et al, 2010;Waqar et al, 2016); -in the treatment of leprosy (Meinao et al, 1996;Bezerra et al, 2005;Gordon et al, 2018);…”
Section: Basis For Directions Of Pathogenetic Therapymentioning
confidence: 99%
“…-for the prevention and treatment of malaria (Mengesha and Makonnen, 1999;Bello et al, 2010;Waqar et al, 2016); -in the treatment of leprosy (Meinao et al, 1996;Bezerra et al, 2005;Gordon et al, 2018);…”
Section: Basis For Directions Of Pathogenetic Therapymentioning
confidence: 99%
“…However, with COVID-19, there are emerging therapies which are purported to be associated with very good treatment outcomes. The Food and Drugs Administration (FDA) of the USA for instance has sanctioned the compassionate use of chloroquine [11], a 4-minoquinoline medicine which has been used for many years to treat rheumatoid arthritis, systemic lupus erythematosus, and porphyria cutanea tarda even though its use in the treatment of malaria in sub-Saharan Africa was banned in the early 2000s due to the incidence of adverse reactions and resistance [12]. This compassionate approval of chloroquine as well as a statement made by President Trump on the possible benefits of chloroquine in the treatment of COVID-19 has led many into believing that chloroquine is a magical COVID-19 drug.…”
Section: Interventionmentioning
confidence: 99%
“…Chloroquine was the recommended as a first-line drug for the treatment of uncomplicated malaria in all age groups in the year 2005, but 17 years later, it usage was officially banned in Nigeria [34] due to the emergence of a massive resistant-chloroquine strain of the parasite, with the hope to reduce drug pressure and with full hope that it may regain it susceptibility after it discontinuance usage in the country. Therefore this surveillance study aimed to evaluate the presence of molecular markers of resistance in the PCRT gene of P. falciparum isolates from Gombe L.G.A, Nigeria after the drug has been officially suspended for treating uncomplicated malaria.…”
Section: Introductionmentioning
confidence: 99%