Is Chronic Inflammation a Possible Cause of Obesity-Related Depression?

Olszanecka-Glinianowicz, Magdalena; Zahorska-Markiewicz, Barbara; Kocełak, Piotr; Janowska, Joanna; Semik-Grabarczyk, Elżbieta; Wikarek, Tomasz; Gruszka, Wojciech; Dąbrowski, Piotr

doi:10.1155/2009/439107

Cited by 15 publications

(11 citation statements)

References 28 publications

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“…Our previous study [18] revealed that about 60.0% of obese subjects starting the group weight reduction program had mild or severe depression levels. Similar results were obtained in the present study (52.6%).…”

Section: Discussionmentioning

confidence: 97%

“…It has already been proved that occurrence of depression may precede the development of obesity and, quite the reverse, the development of depression may follow development of obesity, moreover, both diseases may develop at the same time [4,5]. Our previous studies [18] revealed that in a population of 217 patients starting the group weight reduction program, the prevalence of depression reached 59%. Numerous recent stud-7 ies have reported that weight loss achieved with a lifestyle modification improved symptoms of depression [19][20][21][22].…”

Section: Introductionmentioning

confidence: 95%

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Is the depression level the factor influencing the effectiveness of the group weight reduction program?

Olszanecka-Glinianowicz¹,

Kocełak²,

Gruszka³

et al. 2014

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Introduction: The aim of the study was to assess the influence of the depression level on the effects of the group weight reduction program. Material and methods:The study group involved 57 overweight and obese subjects [age 45.9 ± 13.9 years, body mass index (BMI) 35.5 ± 5.4 kg/m 2 ]. All patients participated in a 3-month group weight reduction program. Body mass and height were measured and BMI was calculated, the depression level was assessed using Beck's Depression Inventory (BDI) at baseline and at the end. Results: At baseline, the moderate depression level occurred in 8 women (BDI 23.1 ± 3.0 points), mild depression level in 22 subjects -20 women and 2 men (BDI 13.4 ± 2.4 points) and 27 subjects -22 women and 5 men did not have features of depression (BDI 5.5 ± 2.8 points). Subjects with severe and mild depression levels were significantly older than these without features of depression (p < 0.005). We did not observe differences of BMI between study subgroups. There were no correlations between body mass and BMI, and the depression levels. The body mass and depression levels decreased significantly in all study subgroups after the group weight reduction program with psychotherapy. We observed a significant decrease in both body mass and depression level in all study subgroups. The mean weight reduction was similar in all study subgroups. Conclusion:The depression level at baseline did not influence the effectiveness of the group weight reduction program.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 95%

Is the depression level the factor influencing the effectiveness of the group weight reduction program?

Olszanecka-Glinianowicz¹,

Kocełak²,

Gruszka³

et al. 2014

noms

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“…The results of a single study revealed that chronic microinflammation related to obesity may be a factor that participates in depression development [45]. However, our study did not confirm this link between obesity and depression [46]. The results of experimental studies have also suggested that gastrointestinal tract hormones, such as ghrelin and peptide YY (PYY), participate in mood disorders development.…”

Section: The Possible Links Between Obesity and Depressionmentioning

confidence: 62%

Psychological Disturbances and Quality of Life in Obese and Infertile Women and Men

Kocełak

Chudek

Naworska

et al. 2012

International Journal of Endocrinology

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Anovulatory cycles and endometriosis are the main causes of female infertility. The most frequently anovulatory cycles are related to polycystic ovary syndrome (PCOS) commonly associated with obesity and hormonal disturbances in the course of obesity. Recently published studies revealed that infertility affects about one in six couples during their lifetime and is more frequent in obese. Obesity is also associated with male infertility related to erectile dysfunction, hormonal disturbances and lower semen quality. Any of these above mentioned disorder is the important risk factor of psychological disturbances and poor quality of life among women and men in the reproductive age. On the other hand the mood disorders may exacerbate the hormonal disturbances and worsen the effectiveness of infertility management. Infertility, its therapy with accompanying psychological disturbances may also significantly affect the partners relationships. The review summarize the results described in the current literature on the association between obesity and infertility and psychological disturbances as well as their impact on quality of life and sexual functioning in women and men. Moreover, the impact of infertility and psychological disturbances on partners relationships is discussed.

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“…As is known, in depression disorders with regulation of the hypothalamicpituitary adrenal, HPA are observed [47]. Nowadays, participation of proinflammatory cytokines in causing depression, cardiovascular diseases and obesity is emphasized [48], [49]. From animal studies results, it is visible that inflammatory processes are observed also in the exposure to air pollution (PM) [50] and their growth in the hippocampus may be associated with the development of clinical depression [47].…”

Section: Discussionmentioning

confidence: 99%

The correlations between air pollution and depression.

Łopuszańska

Makara‐Studzińska

2017

Current Problems of Psychiatry

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Introduction: In the 21st century there is an increased prevalence of depression in the world. So far the mechanism of developing depression has not been exactly known. Risk factors of depression occurrence are complex and nowadays it has been emphasized that air pollution can affect the intensity of depressive symptoms.Objective: The analysis of the scientific works investigating the correlations between air pollution and depression.Material and method: The material consisted of the studies published between 2007 and 2017. A systematic review of Medline database (using PubMed search engine) was conducted by typing the English phrase (air pollution) and (depression), and 154 results were obtained. Those results which concerned nicotine addiction or dementia diseases were rejected. The inclusion criterion was the number of people tested, n>500 in case of adults, and n>200 in case of children (a small number of publications). All in all, 9 research in the population of adults and 1 research in the group of children were included to the final analysis. In the discussion part of this work some research carried out on animals and related to the subject matter of own analyses were also investigated.Results: As many as 8 out of 10 analyzed research demonstrated statistically significant correlation between long-term exposure to air pollution (mainly to fine particulate matter, PM) and depression. This correlation mainly concerned intensification of depressive symptoms during long exposure to air pollution. The exposure also resulted in changes in the neuro-transfer of serotonin and as well in neurodegenerative changes in children exposed to long-term pollution with polycyclic aromatic hydrocarbons (PAH) in prenatal life. Testing on animals indicates that air pollution affects the activation of proinflammatory processes in hippocampus, what may incidentally contribute to the formation of depressive and cognitive symptoms.Conclusions: In view of the increase of depression incidence and constantly sustained air pollution in the world, there is a need for further research on the correlation between air pollution and depression, taking into account the genetic, social and psychological factors.

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Is Chronic Inflammation a Possible Cause of Obesity-Related Depression?

Cited by 15 publications

References 28 publications

Is the depression level the factor influencing the effectiveness of the group weight reduction program?

Is the depression level the factor influencing the effectiveness of the group weight reduction program?

Psychological Disturbances and Quality of Life in Obese and Infertile Women and Men

The correlations between air pollution and depression.

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