Is Chronic Kidney Disease Associated with a High Ankle Brachial Index in Adults at High Cardiovascular Risk?

Líu, Hao; Shi, Hong; Yu, Jinming; Chen, Fang; Jiang, Qingwu; Hu, Dayi

doi:10.5551/jat.6056

Cited by 14 publications

(13 citation statements)

References 35 publications

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“…11 Our results show that eGFR in groups with an ABI between 1.0 and 1.1 was significantly higher than other groups (P ¼ .000). Using this group as a reference, both a decrease and an increase in ABI were associated with a lower eGFR, showing a bell-shaped curve, which is consistent with the results of Liu Hao et al 7 The results also showed consistency between the change in ABI and eGFR, indicating a close relationship between lower PAD and kidney function.…”

Section: Discussionsupporting

confidence: 91%

An Analysis of the Relationship Between Ankle–Brachial Index and Estimated Glomerular Filtration Rate in Type 2 Diabetes

Jin

Shen

et al. 2012

Angiology

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We investigated the relationship between peripheral arterial disease (PAD) and renal function in patients with type 2 diabetes mellitus (T2DM). We enrolled 2057 hospitalized patients with T2DM and measured kidney function and ankle-brachial index (ABI). The estimated glomerular filtration rate (eGFR) was derived using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and ABI was grouped as low (<0.9), low-normal (0.9-1.09), normal (1.1-1.3), and high (>1.3). Logistic regression was used to evaluate the associations of eGFR with ABI. Generally speaking, the ABI was negatively correlated with systolic blood pressure, fasting C-peptide, total cholesterol, and low-density lipoprotein cholesterol while positively correlated with body mass index (P < .05 to <.01). Only a low ABI was positively correlated with eGFR (P < .01). In addition to the association of the ABI with cardiovascular events, stroke, and PAD, ABI may also predict the change in renal function in patients with T2DM.

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Section: Discussionsupporting

confidence: 91%

An Analysis of the Relationship Between Ankle–Brachial Index and Estimated Glomerular Filtration Rate in Type 2 Diabetes

Jin

Shen

et al. 2012

Angiology

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“…Previous studies have shown that the cardioankle vascular index is independently correlated with eGFR, and that a high ankle brachial index is associated with an increased risk of CKD in diabetic patients 33,34) . This seems to be in line with our study demonstrating that both improvements in the cardioankle vascular index and ankle-brachial index were non-significantly higher in fluvastatin plus ezetimibe where significant improvement in eGFR was observed.…”

Section: Efficacy Of Add-on Ezetimibe On Renal Functionmentioning

confidence: 99%

Effects of Adding Ezetimibe to Fluvastatin on Kidney Function in Patients with Hypercholesterolemia: a Randomized Control Trial

Kinouchi

Ichihara

Bokuda

et al. 2013

JAT

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Aims:Statins not only reduce low-density lipoprotein (LDL) cholesterol, but also prevent the progression of kidney dysfunction. Ezetimibe, a cholesterol-absorption inhibitor, also lowers LDL cholesterol levels when added to statins; however, the effect of add-on ezetimibe on kidney function has had conflicting results. Methods:We conducted an open-labeled, randomized, 12-month trial, comparing the effects of daily therapy with 20 mg fluvastatin either with or without 10 mg ezetimibe in 54 patients with dyslipidemia. The prespecified primary outcome was the percent change from baseline in kidney function, which was defined by the estimated glomerular filtration rate. The secondary outcomes were the changes in surrogate atherosclerotic markers. All analyses were by intention to treat.

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“…Patients with an ABI <0.9 and albuminuria had a significantly higher risk of composite events and all-cause mortality than those in the other groups. In a related study, Liu et al 41 examined patients at high risk of cardiovascular disease and measured kidney function and ABI. Their analysis showed that high ABI values were associated with increased risk of CKD in patients with DM and high risk of cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Relationships between Chronic Comorbidities and the Atherosclerosis Indicators Ankle-Brachial Index and Brachial-Ankle Pulse Wave Velocity in Patients with Type 2 Diabetes Mellitus

Lee

Tsai

Liu³

et al. 2018

Journal of Investigative Medicine

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This study aimed to determine associations between ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) with different comorbidities in patients with type 2 diabetes mellitus (DM). Records of patients with type 2 DM who received an ABI and baPWV examination between August 2013 and February 2015 were retrospectively reviewed. Associations of ABI and baPWV with chronic kidney disease (CKD), chronic liver disease (CLD), coronary artery disease (CAD) and diabetic nephropathy (DN) were examined by regression analysis. A total of 1232 patients (average age, 65.1±10.0 years) were included in the analysis. CKD and DN were associated with low ABI and increased baPWV (all, P<0.001). No associations were found between CAD and CLD and ABI or baPWV. Thus, regression analysis was performed for CKD and DN. Low ABI was associated with risk of CKD in the crude model (OR 0.724, 95% CI 0.648 to 0.808, P<0.001) and adjusted model (OR 0.872, 95% CI 0.762 to 0.999, P=0.048), whereas baPWV was only significant in the crude model (OR 1.199, 95% CI 1.112 to 1.294, P<0.001). Low ABI was associated with risk of DN in the crude model (OR 0.873, 95% CI 0.780 to 0.977, P=0.018) and adjusted model (OR 0.884, 95% CI 0.782 to 0.999, P=0.048). No association was found for baPWV. In conclusion, low ABI was associated with risk of CKD and DN in patients with type 2 diabetes.

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Is Chronic Kidney Disease Associated with a High Ankle Brachial Index in Adults at High Cardiovascular Risk?

Cited by 14 publications

References 35 publications

An Analysis of the Relationship Between Ankle–Brachial Index and Estimated Glomerular Filtration Rate in Type 2 Diabetes

An Analysis of the Relationship Between Ankle–Brachial Index and Estimated Glomerular Filtration Rate in Type 2 Diabetes

Effects of Adding Ezetimibe to Fluvastatin on Kidney Function in Patients with Hypercholesterolemia: a Randomized Control Trial

Relationships between Chronic Comorbidities and the Atherosclerosis Indicators Ankle-Brachial Index and Brachial-Ankle Pulse Wave Velocity in Patients with Type 2 Diabetes Mellitus

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