Is chronic plaque psoriasis triggered by microbiota in the skin?

Fry, Lionel; Baker, Barbara S.; Powles, A.V.; Fahlén, Annika; Engstrand, Lars

doi:10.1111/bjd.12322

Cited by 108 publications

(97 citation statements)

References 55 publications

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“…It has been proposed that a maladaptive innate immune response to the skin microbiota may be a key initiating event [5]. Increased numbers of dermal dendritic cells are activated by various innate immune cells, including macrophages, keratinocytes and NK T cells.…”

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confidence: 99%

Efficacy and Safety of Emerging Immunotherapies in Psoriasis

Yiu

Warren

2015

Immunotherapy

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Psoriasis is a common chronic inflammatory disease of the skin. Current biologic therapies are highly effective in the treatment of psoriasis, transforming the lives of patients with this significantly disabling disease. Advances in the understanding of the immunological pathogenesis of psoriasis have led to the development of new biologic therapies, targeting specific inflammatory cytokines upregulated in psoriasis. These include the IL-17 antagonists, secukinumab, brodalumab and ixekizumab; the IL-23 antagonists, guselkumab and tildrakizumab; and the oral small molecule therapies, tofacitinib and apremilast. Here, we review evidence for the efficacy and safety of these novel psoriasis therapies, providing clinicians with an overview of the next era in immunotherapy for psoriasis.

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mentioning

confidence: 99%

Efficacy and Safety of Emerging Immunotherapies in Psoriasis

Yiu

Warren

2015

Immunotherapy

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“…While these studies have identified potential differences in the composition of the microbiota between psoriatic and normal skin, no consensus microorganisms have been directly identified and linked to disease pathogenesis. Additionally, the number of innate immune-related genetic factors identified in patients with psoriasis further complicates the issue, again leaving researchers without a definitive cause-and-effect relationship between disease and microbial diversity [79,82]. …”

Section: Consequences Of Dysbiosis In the Microbiomementioning

confidence: 99%

Functions of the skin microbiota in health and disease

Sanford

Gallo

2013

Seminars in Immunology

381

303

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The skin, the human body’s largest organ, is home to a diverse and complex variety of innate and adaptive immune functions. Despite this potent immune system present at the cutaneous barrier, the skin encourages colonization by microorganisms. Characterization these microbial communities has enhanced our knowledge of the ecology of organisms present in normal skin; furthermore, studies have begun to bring to light the intimate relationships shared between host and resident microbes. In particular, it is apparent that just as host immunological factors and behaviors shape the composition of these communities, microbes present on the skin greatly impact the functions of human immunity. Thus, today the skin immune system should be considered a collective mixture of elements from the host and microbes acting in a mutualistic relationship. In this article we will review recent findings of the interactions of skin microbial communities with host immunity, and discuss the role that dysbiosis of these communities plays in diseases of the skin.

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“…Conversely, shifting of microbial communities can alter host–microbiome interactions has been associated with disease [22–24]. To better understand those changes in microbial compositions, the dynamics of microbial interactions at the skin surface will be discussed briefly.…”

Section: Host Interactions With Skin Microbiotamentioning

confidence: 99%

Structure and function of the human skin microbiome

Schommer¹,

Gallo²

2013

Trends in Microbiology

378

291

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An abundant and diverse collection of bacteria, fungi and viruses inhabit the human skin. These microorganisms have been reported to vary between individuals and between different sites on the skin. The factors responsible for the unique variability of the skin microbiome are only partially understood, but results suggest host genetic and environmental influences play a major role. Today, the steady accumulation of data describing the skin microbiome, combined with experiments designed to test the biological functions of surface microbes, have provided new insights into links between human physiology and skin microbiota. This review describes some of the current information regarding the skin microbiome and their impact on human health. Specifically, this review seeks to summarize the present understanding of the function of microbe–host interactions on the skin and highlight some unique features that distinguish skin commensals from pathogenic microbes.

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Is chronic plaque psoriasis triggered by microbiota in the skin?

Cited by 108 publications

References 55 publications

Efficacy and Safety of Emerging Immunotherapies in Psoriasis

Efficacy and Safety of Emerging Immunotherapies in Psoriasis

Functions of the skin microbiota in health and disease

Structure and function of the human skin microbiome

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