Is Classic Kaposi’s Sarcoma Endemic in Peru?: Report of a Case in an Indigenous Patient

Mohanna, Salim; Maco, Vicente; Gown, Allen M.; Morales, Domingo; Bravo, Francisco; Gotuzzo, Eduardo

doi:10.4269/ajtmh.2006.75.324

Cited by 15 publications

(14 citation statements)

References 16 publications

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“…A partir de estos casos, Mohanna et al consideraron la posibilidad que el SK en la población peruana es una condición frecuente e independiente de la infección por VIH (8) ; a ello se debe sumar el hecho que los registros oncológicos peruanos previos a los años de la epidemia de SIDA ya mostraban una incidencia relativamente alta de SK, en comparación con lo encontrado en otros países latinoamericanos; más llamativo aún era que la población afectada no era de origen europeo sino andino (9) . Además, las formas clínicas atípicas, tales como lesiones bilaterales, patrones zosteriformes o presentaciones que primariamente afectaban cabeza y cuello, usuales en el contexto de la infección por VIH pero raras en la forma clásica, no eran inusuales en pacientes autóctonos peruanos con serología negativa para VIH.…”

Section: Virus Papiloma Humanounclassified

Virus como inductores de neoplasias cutáneas

Puccio

2014

Rev Peru Med Exp Salud Publica

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El rol oncogénico de los virus en las neoplasias cutáneas es conocido por el hombre desde hace más de un siglo, cuando se atribuía el origen de la verruga vulgar al virus papiloma humano (VPH). En la actualidad, las neoplasias inducidas por virus pueden agruparse en tumores sólidos y procesos linfoproliferativos. Destacan entre los primeros el VPH, del cual ahora conocemos numerosos serotipos, cada uno vinculado a una neoplasia específica, el herpesvirus humano tipo 8 que produce el sarcoma de Kaposi y el poliomavirus vinculado al carcinoma de Merkel. Entre los procesos linfoproliferativos debemos mencionar al virus linfotrópico de células T humanas tipo 1 (HTLV-1) responsable de los linfomas de células T, en los cuales el compromiso cutáneo es inespecífico, con un amplio espectro de presentaciones clínicas y, que por consiguiente, plantean un reto para el diagnóstico diferencial. En este grupo también se encuentra el virus Epstein Barr vinculado a los linfomas nasales de Células NK/T y a los linfomas tipo Hidroa, de reciente descripción. En esta era en la que lo genético y lo molecular priman en las investigaciones en cáncer, no podemos dejar de lado el concepto de neoplasia como resultado de la infección por un agente viral, lo que abre una nueva veta de posibilidades de tratamiento anticanceroso basado en medicamentos antivirales. Palabras clave: Papillomaviridae; Poliomavirus; Carcinoma de células escamosas; Carcinoma de células de Merkel; Virus linfotrópico de células T humanas tipo 1; Linfoma extranodal de células NK-T (fuente: DeCS BIREME). VIRUSES AS AGENTS INDUCING CUTANEOUS NEOPLASMS ABSTRACTThe oncogenic role of viruses in cutaneous neoplasms has been known by humankind for more than a century, when the origin of the common wart, or verruca vulgaris, was attributed to the human papilloma virus (HPV). Currently, virusinduced cutaneous neoplasms may be grouped into solid tumors and lymphoproliferative disorders. HPV, from which various serotypes are now known, each being linked to a specific neoplasm, the human herpes virus type 8 producing Kaposi sarcoma, and the Merkel cell polyomavirus, highlight among the first group. Regarding the lymphoproliferative disorders, we should mention the human T-lymphotropic virus type I (HTLV-1), which is responsible for the T-cell lymphomas, in which the cutaneous manifestations are non-specific and have a wide spectrum, thus posing a challenge for differential diagnosis. The Epstein Barr virus, linked to nasal lymphomas of NK/T-cells and Hydroa-like cutaneous lymphomas, is also part of this group. In an era in which the genetic and molecular aspects of cancer research prevail, we may not leave behind the concept of neoplasms as a result an infection with a viral agent, which opens a wide array of new possibilities for cancer treatment based on antiviral drugs.

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Section: Virus Papiloma Humanounclassified

Virus como inductores de neoplasias cutáneas

Puccio

2014

Rev Peru Med Exp Salud Publica

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“…The fact that our patient is of sub-Saharan African origin is rather unusual for classical KS. Nevertheless, occurrence of classical KS in non-Mediterranean countries such as Peru and China has been documented [7,8]. The striking geographical variation in the incidence of classical KS and African-endemic KS points to a role for environmental factors.…”

Section: Iroezindu and Achusi Classical Kaposi's Sarcoma In Nigeriamentioning

confidence: 99%

Classical Kaposi’s Sarcoma in a Nigerian Farmer: A Case Report

Iroezindu¹,

Achusi²

2015

Eurasian J Med

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Classical Kaposi's sarcoma (KS) typically affects elderly men of Mediterranean and Jewish origin. We present an unusual case of classical KS in a human immunodeficiency virus (HIV) negative elderly farmer from rural Nigeria. He had multiple brownish nodules and plaques on both lower extremities associated with lymphoedema. Histopathological examination of a biopsy of the skin nodule confirmed the diagnosis of KS. The lesions only showed marginal improvement on chemotherapy which necessitated a referral for radiotherapy. There is a need to look beyond the traditional geographical distinction of KS variants as we continue to experience a dynamic role for environmental co-factors in the development of KS.

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“…It is a malignancy of skin, mucous membranes and blood vessels (Gilani et al 2009). It has a known association with Human Immunodeficiency Virus (HIV) infection (Sanna et al 2000& Mohanna et al 2006. It was the first clue to the diagnosis of Acquired Immunodeficiency Syndrome (AIDS) in the late 1970's (Beral et al 1990).…”

Section: Introductionmentioning

confidence: 99%

“…HHV-8 infection is required for the development of classical KS, but not all infected persons develop the disease. Four variants of are known that is classical (sporadic), endemic (African), iatrogenic (immunosuppressive drugs associated) and AIDS-associated (Mohanna et al 2006& Solivetti et al 2011). Classic KS occurs sporadically and is seen in immunocompetent individuals and may present as bluish-red or hyper-pigmented papules, plaques or nodules over feet or hands with pedal edema (Mohanna et al 2006& Mohanna et al 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Four variants of are known that is classical (sporadic), endemic (African), iatrogenic (immunosuppressive drugs associated) and AIDS-associated (Mohanna et al 2006& Solivetti et al 2011). Classic KS occurs sporadically and is seen in immunocompetent individuals and may present as bluish-red or hyper-pigmented papules, plaques or nodules over feet or hands with pedal edema (Mohanna et al 2006& Mohanna et al 2007). The incidence is higher in Southern and Eastern European countries and the condition is more commonly found in Jewish, Italian and Greek populations (Dal Maso et al 2005).…”

Section: Introductionmentioning

confidence: 99%

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A Rare non-auto immunodeficiency disease (AIDS) related neo-plasm Kaposi sarcoma in Iraqi man: a case report

Al-Helfi¹,

Al-Saad

Alshewered³

2015

IJM

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<p>The aim of this article is to report unusual case of KS presenting in the patient with negative serology for AIDS. Kaposi Sarcoma (KS) is a rare entity. It is a vascular neoplasm mainly affecting the skin of the lower extremities. Although it is the most common neoplasm affecting patients with AIDS, sporadic cases in HIV-negative people have been reported but it is rare. Here, we present a case of a non-auto immunodeficiency disease (AIDS) related KS. A 72 year-old male, Iraqi patient presented to our oncology outpatient’s unit in Al-Shafaa Oncology Center with multiple subcutaneous nodules. The diagnosis was based on histopathological and immunohistochemical analysis of the excised lesion, serology tests and imaging investigations. The patient had a 13-month history of a slowly progressing pigmented multiple lesions on the lower and upper extremities. The patient had visceromegaly as splenomegaly at the time of presentation. His serum was negative for the common types of viral infections including Human Immunodeficiency Virus (HIV) on routine serology. On general examination, the man look well, no pallor, no fever, no cachexia present and no jaundice. There are a multiple ill defined, irregular hyper-pigmented nodules to plaques were present on forearm, legs, feet and hands. The nodules and plaque was firm in consistency and was non-tender. The lesions were deep reddish to brownish in color. The size of the lesions were arranged from 0.5-1.5 cm. No scaling was evident. The patient was under treatment with chemotherapeutic regimen of Paclitaxel. </p>

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Is Classic Kaposi’s Sarcoma Endemic in Peru?: Report of a Case in an Indigenous Patient

Cited by 15 publications

References 16 publications

Virus como inductores de neoplasias cutáneas

Virus como inductores de neoplasias cutáneas

Classical Kaposi’s Sarcoma in a Nigerian Farmer: A Case Report

A Rare non-auto immunodeficiency disease (AIDS) related neo-plasm Kaposi sarcoma in Iraqi man: a case report

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