Is Colorectal Carcinoma in the Young a More Deadly Disease?

D’Onofrio, Giuseppe; Tan, Ernest

doi:10.1111/j.1445-2197.1985.tb00940.x

Cited by 36 publications

(27 citation statements)

References 10 publications

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“…However, we did detect a trend to increased recurrence incidence in patients with colorectal carcinoma r40 years of age. Numerous singleinstitution studies have demonstrated poor clinical outcomes for patients with early-onset colorectal carcinoma, [5][6][7][8][9] although none of these studies specifically excluded Lynch syndrome patients from their survival analyses. A number of these studies 5,6 found that patients with colorectal carcinoma r40 years of age had increased incidence of colorectal carcinoma with mucinous histology, a morphologic finding that is often seen in association with Lynch syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous singleinstitution studies have demonstrated poor clinical outcomes for patients with early-onset colorectal carcinoma, [5][6][7][8][9] although none of these studies specifically excluded Lynch syndrome patients from their survival analyses. A number of these studies 5,6 found that patients with colorectal carcinoma r40 years of age had increased incidence of colorectal carcinoma with mucinous histology, a morphologic finding that is often seen in association with Lynch syndrome. Other literature reports, including a large populationbased analysis with SEER data, have found that while young patients with colorectal carcinoma often present with advanced stage disease, these patients tend to have an equivalent or better cancer-specific survival rates compared with older patients.…”

Section: Discussionmentioning

confidence: 99%

“…A number of reports have demonstrated poor clinical outcomes for these patients. [5][6][7][8][9] Other reports have found an equivalent or better cancer-specific survival rates in young patients compared with older patients despite presenting with advanced stage disease. 8,10 The limited literature data are also conflicting with regards to the more common locations of colorectal carcinoma, with some indicating increased frequency of proximal right-sided colorectal carcinoma 11 while others demonstrating increased frequency of rectal and rectosigmoid carcinoma.…”

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Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features

et al. 2012

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Recent literature suggests an increasing incidence of colorectal carcinoma in young patients. We performed a histologic, molecular, and immunophenotypic analysis of patients with sporadic early-onset (r40 years of age) colorectal carcinoma seen at our institution from the years 2000-2010 and compared these tumors to a cohort of consecutively resected colorectal carcinomas seen in patients 440 years of age. A total of 1160 primary colorectal adenocarcinomas were surgically resected for the years 2000 through 2010. Of these, 75 (6%) were diagnoses in patients r40 years of age of which 13 (17%) demonstrated abnormalities in DNA mismatch repair, 4 (5%) were in patients with known germline genetic disorders (two patients with familial adenomatous polyposis, one patient with juvenile polyposis, and one patient with Li-Fraumeni syndrome), and three patients (4%) had long-standing chronic inflammatory bowel disease. The sporadic early-onset colorectal carcinoma group comprised a total of 55 patients (55/1160, 5%) and were compared with a control group comprising 73 consecutively resected colorectal carcinomas with proficient DNA mismatch repair in patients 440 years of age. For the early-onset colorectal carcinoma group, most cases (33/55, 60%) were diagnosed between the age of 35 and 40 years of age. Compared with the control group, the early-onset colorectal carcinoma group was significantly different with respect to tumor location (Po0.007) with 80% (44/55 cases) identified in either the sigmoid colon (24/55, 44%) or rectum (20/55, 36%). Morphologically, early-onset colorectal carcinomas more frequently displayed adverse histologic features compared with the control colorectal carcinoma group such as signet ring cell differentiation (7/55, 13% vs 1/73, 1%, P ¼ 0.021), perineural invasion (16/55, 29% vs 8/73, 11%, P ¼ 0.009) and venous invasion (12/55, 22% vs 4/73, 6%, P ¼ 0.006). A precursor adenomatous lesion was less frequently identified in the early-onset colorectal carcinoma group compared with the control group (19/55, 35% vs 39/73, 53%, P ¼ 0.034). Of the early-onset colorectal carcinomas, only 2/45 cases (4%) demonstrated KRAS mutations compared with 11/73 (15%) of the control group colorectal adenocarcinomas harboring KRAS mutations, although this difference did not reach statistical significance (P ¼ 0.13). BRAF V600E mutations were not identified in the early-onset colorectal carcinoma group. No difference was identified between the two

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features

et al. 2012

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“…It is known that budding or microtubular structure detected nore frequently than 20% in pathological examinations increases the risk of LNM in T1 colorectal cancers (24) . The mucinous and poorly differentiated tumors have a worse prognosis than well and intermediately differentiated tumors (26) . In the study of Ozdemir et al, (27) mucinous tumors were more frequently reported in colorectal cancers that were seen in young patients.…”

Section: Resultsmentioning

confidence: 96%

The Clinical And Pathologıcal Factors Affecting Lymph Node Metastasis In Patıents Operated On with the dıagnosıs of Colorectal Cancer

Üstüner¹,

İlhan²,

Yeldan³

et al. 2016

Terh

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Objective: We aimed to examine the clinical and the pathological factors that affect lymph node metastasis, which is an important prognostic factor in the survival of the patients with colorectal cancer, and to determine the most appropriate patient-centered treatment method. Methods:The file records and electronic data of the patients who had been operated on with the diagnosis of colorectal cancer at the General Surgery Clinic between May 2008 and December 2012 were retrospectively evaluated. Results: Seventy-four patients including 50 males (67.6%) and 24 females (32.4%) were included in the study. The mean age of the patients was 69.3 years (range: 38-60 years). While lymphovascular invasion was observed in 21 (28.4%), and perineural invasion in 19 (25.7%) patients. When the growth pattern was examined, 48 patients (64.9%) demonstrated ulcerovegetative, 18 patients (24.3%) ulcerated, eight patients (10.8%) polyp-type growth patterns. The most frequent tumor localization was the middle third of rectum (n=20; 27%) and the most common type of surgery was the Miles operation (n=16; 21.6%). Conclusion: In conclusion, the risk of LNM significantly increases in patients with colorectal cancer who have surgical radial margin, lymphovascular and perineural invasion. Over time, the other risk factors affecting LNM will be determined with large scale studies that can be conducted together with advancing technology and broad sources of knowledge. In this way, minimally invasive surgery can be performed on cases with colon cancer and the patients will be protected from the side effects of unnecessary chemotherapy.Key words: Lymph node metastasis, colorectal cancer, lypmphovasculer invasion ÖZ Amaç: Kolorektal kanserli hastalarda sağkalımda önemli bir prognostik faktör olan lenf nodu metastazına etki eden klinik ve patolojik faktörleri inceleyerek hasta merkezli en uygun tedaviyi belirlemeyi amaçladık. Yöntemler: Cerrahi kliniğinde Mayıs 2008-Aralık 2012 tarihleri arasında kolerektal kanser tanısıyla ameliyat edilen hastaların dosya kayıtları ve elektronik ortam bilgileri retrospektif olarak incelendi. Bulgular: Araştırmamızda bulunan 74 hastanın 50'si (%67,6) erkek, 24'ü (%32,4) kadın-dı. Hastalarımızın yaş ortalaması 69,3 (38-60) yıl olarak bulundu, 50 (%67,6) hasta 65 yaş üstünde, 24 (%32,4) hasta 65 ve altındaydı. Yirmi bir (%28,4) hastada lenfovasküler invazyon gözlenirken 19 (%25,7), hastada perinöral invazyon gözlendi. Gelişim paternine baktığımızda 48 (%64,9) hasta ülserovegatatif, 18 (%24,3) hasta ülsere, 8 (%10,8) hastanın polip tipte gelişim paterni gösteriyordu. En sık gözlenen tümör lokalizasyonu rektum orta 1/3 olarak bulurken (20 (%27)), en sık yapılan operasyon Miles operasyonu olarak karşımıza çıktı (16 (%21,6)). Sonuç: Sonuç olarak, kolon kanserlerinde lenfovasküler invazyon, perinöral invazyona sahip hastalarda LNM riski önemli ölçüde artmaktadır. Zaman içinde, gelişen teknoloji ve bilgi birikimiyle yapılacak olan daha kapsamlı çalışmalarla LNM'yi etkileyen diğer risk faktörler de bulunacaktır. ...

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“…In conducted studies, these two features were reported to be detected in higher rates in young patients 14 . Berut M et al 10 reported the rate of mucinous carcinoma as 55% and poor differentiation ratio as 9.6%.…”

Section: Cumhuriyet Medical Journalmentioning

confidence: 99%

Evaluation of colorectal cancers in young patients

Kısaoğlu¹,

Özoğul²,

Atamanalp³

et al. 2015

Cumhuriyet Med J

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SUMMARYObjective: Even though the colorectal cancer is less common in young patients, it has a worse prognosis. The incidence of colorectal cancer in this age group is increasing in recent years. In this study we investigated young patients with colorectal cancer, whose follow-ups and treatments were performed in our clinic, according to the literature. Method: In our clinic the records of 39 patients under 40 years of age were examined between January 2005 and September 2013 retrospectively. Age and gender of the patients, tumor localizations, the shape of the operation and the tumor pathological features were recorded. Results: 19 patients (48.7%) were female, 20 (51.3%) were male and mean age was 32.6 (19-39) years. 34 patients (87.2%) operated electively and 5 patients (12.8%) had emergency surgery. The localization of the tumor was mostly in the rectum (41.0%, n = 16). For 13 (33.3%) patients, who have the tumor localized in the right column, right hemicolectomy was performed. For patients, who have the tumor localized in the rectum, mostly low anterior resection was performed and totally for 7 patients, a stoma was opened. Pathological investigation revealed mucinous adenocarcinoma in 17 (43.6%) patients. Conclusion: Rectal cancer is more common in young patients with colorectal cancer and is often diagnosed at an advanced stage. Therefore in this patient group, complaints, which cause suspicion of colorectal cancer, should be examined carefully and advanced inspection methods should be performed.

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Is Colorectal Carcinoma in the Young a More Deadly Disease?

Cited by 36 publications

References 10 publications

Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features

Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features

The Clinical And Pathologıcal Factors Affecting Lymph Node Metastasis In Patıents Operated On with the dıagnosıs of Colorectal Cancer

Evaluation of colorectal cancers in young patients

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