Is contact allergy rare in psoriatics?

Barile, Mônica; Cozzani, Emanuele; Anonide, Antonio; Usiglio, David; Burroni, A.; Guarrera, Marcella

doi:10.1111/j.1600-0536.1996.tb02309.x

Cited by 29 publications

(34 citation statements)

References 4 publications

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“…Thus relatively high rates to the top five allergens among psoriatics can reflect contact sensitization to yarrow extract ( Achillea millefolium) and extracts of other Compositae plants, lanolin and benzocaine from pharmaceutical products (table 3). Just like in most other reports on contact allergy in psoriasis, nickel was found to be the most common allergen in the standard series that showed positive PTs [2,7,8,9, 13, 22]. Apart from these, rates differing in the two sexes were found for several allergens, e.g.…”

Section: Discussionsupporting

confidence: 63%

“…The overall frequency of contact allergy in patients with chronic plaque psoriasis was 26.78%. Previously published data have shown a prevalence of 20–25% [7,8,9,10,11]. However, regarding data on other forms of the disease, a great diversity exists mostly because of the large heterogeneity in the clinical appearance of psoriasis and some immunologic differences [12].…”

Section: Discussionmentioning

confidence: 99%

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Contact Sensitivity in Patients with Psoriasis in Vojvodina

Jovanović

Boża²,

Karadaglić

et al. 2008

Int Arch Allergy Immunol

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Background: Immunologic studies indicate that psoriasis may represent an organ-integrated response. Objective: We assessed contact hypersensitivity in plaque-type psoriasis, its frequency, etiology and association with severity of psoriasis. Methods: Contact hypersensitivity was defined as a positive patch test (PT) to at least one of 44 ubiquitous contact allergens. Patients with exclusively plaque psoriasis and control groups (patients with allergic contact or extrinsic atopic dermatitis and healthy persons) were tested with the European standard series; plant-related standard allergens; Compositae allergens, and our own extracts from Compositae plants ubiquitous in Vojvodina. Sensitization rates to allergens were standardized for age and sex, and rates in women and in men were both standardized for age. Disease severity was evaluated using the Psoriasis Area Severity Index score. Results: 15,123 PTs were performed. Among psoriatic patients in Vojvodina, the overall rate of sensitivity, standardized for age and sex, was 18.9%. Rates in women (27.7%) and men (5.8%), both standardized for age, were significantly different. Male psoriatic patients reacted less than healthy males, the difference being on the margin of significance. There was no relationship between severity of disease and PT reactivity. Yarrow extract, nickel and a Compositae mix were the most common allergens that produced positive reactions. Conclusion: Although patch testing in psoriatic patients can be quite challenging, time-consuming and difficult, it will provide further insight into the pathophysiology of psoriasis. Factors other than different exposure to allergens may also be responsible for a sex-related difference in contact sensitivity. Future studies should focus on this field.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Contact Sensitivity in Patients with Psoriasis in Vojvodina

Jovanović

Boża²,

Karadaglić

et al. 2008

Int Arch Allergy Immunol

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“…In Fleming's research, we can find very often: nickel, aromatic mixture, birch tar, rosin and neomycin. However, any significant differences concerning the results were noted [18,19]. Bangsgaard's research showed weaker contact hypersensitivity in psoriasis with reference to the control group without psoriasis [20].…”

Section: Discussionmentioning

confidence: 90%

Analysis of selected allergic reactions among psoriatic patients

Weryńska-Kalemba

Filipowska-Grońska

Kalemba

et al. 2016

pdia

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Introduction Psoriasis is a chronic and recurrent inflammatory skin disease. The aetiology is still unknown in spite of numerous scientific researches. There is very little evidence which does not provide enough knowledge about allergic reactions in psoriatic patients. Based on the fact that the epidermal barrier damage allows different allergen types to penetrate into deep layers of epidermis and skin, we can assume that it may lead to immunological reactions. Aim To investigate the allergic reaction indicators and hypersensitivity assessment about contact, inhalant and food allergens. The results were analysed with regard to clinical disease indicators and progression stage of dermal lesions. Material and methods Eighty patients with psoriasis were examined. The concentration of total IgE antibodies and allergen specific IgE antibodies (asIgE) were analysed. Standard epidermal tests and atopy patch tests were performed. All the patients were estimated for their dermatological condition based on the PASI scale. The control group consisted of 50 patients without psoriasis and allergic history. Results Significantly higher concentration of total E immunoglobulin has been stated in the patients with psoriasis. Higher concentrations of specific allergic IgE antibodies were more often observed in the examined group but the most frequently observed values were present in 1–3 class. The most common airborne allergens were birch, artemisia, timothy and rye pollens. There have not been any significant statistical differences in the case of positive epidermal test results. Conclusions There is slightly expressed hypersensitivity in psoriatic patients. This hypersensitivity degree correlates with the intensification of symptoms.

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“…Other studies have observed positivity in 20 to 25% of patients with psoriasis. [3915–17] One study[2] showed no difference in the frequency of allergic reactions between atopics, healthy persons, or psoriatics, whereas Henseler and Christophers[7] calculated that ACD was 3 times less frequent in patients with psoriasis compared with a control group. Another study by Stinco et al .…”

Section: Discussionmentioning

confidence: 99%

“…While some have suggested that allergic contact dermatitis (ACD) is uncommon in psoriasis, others have reported a frequent association. [1–9] In some psoriasis patients, the site of lesions and resistance to treatment often suggests the involvement of local triggering factors such as ACD. [8]…”

Section: Introductionmentioning

confidence: 99%

Prevalence and relevance of secondary contact sensitizers in subjects with psoriasis

Krupashankar

Manivasagam

2012

Indian Dermatol Online J

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Background:Psoriasis may be complicated by contact dermatitis due to an impaired cutaneous barrier. Patch testing helps elucidate sensitizers if any.Aims:To determine the prevalence and relevance of secondary contact dermatitis in subjects with psoriasis.Materials and Methods:Patch testing with Indian Standard Series was done and readings interpreted after 48 and 96 hours.Results:Among 110 subjects 47 (42.7%) showed reactions to at least one antigen. Fifteen (13.6%) reacted to fragrance mix, 10 (9.1%) to nickel sulfate, seven (6.4%) to parthenium, and six (5.5%) to balsam of Peru. Palmoplantar psoriasis was the commonest type of psoriasis patch tested. Fragrance mix was the commonest antigen showing 100% current relevance as an aggravating factor of psoriasis. Cosmetics, beauty preparations, skin and healthcare products followed by topical medications were found to be the most common sources of the patch test positivity.Conclusions:Secondary contact dermatitis is common in patients with psoriasis. Patch testing is necessary to determine the triggering or aggravating antigens in these patients to avoid sensitizers and improve quality of life.

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Is contact allergy rare in psoriatics?

Cited by 29 publications

References 4 publications

Contact Sensitivity in Patients with Psoriasis in Vojvodina

Contact Sensitivity in Patients with Psoriasis in Vojvodina

Analysis of selected allergic reactions among psoriatic patients

Prevalence and relevance of secondary contact sensitizers in subjects with psoriasis

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