Is CONUT score a prognostic index in patients with diffuse large cell lymphoma?

G, Akgün Çağlıyan; Hacioglu, Sibel; B, Ünver Koluman; İlkkılıç, Kadir; R, Nar; Mn, Başer; Bozdemir, Aslı; Şenol, Hande; N, Şen Türk; Erol, Veysel; Yılıdırım, O; Çağlıyan, Ö; Güler, Nil

doi:10.3906/sag-2101-406

Cited by 11 publications

(24 citation statements)

References 15 publications

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“…Six studies ( 10 , 14 – 18 ) investigated the OS of patients with hematologic malignancy. Following the results of the heterogeneity test with an I ² value 58.3 and a P-value of 0.035, the random-effects model was chosen.…”

Section: Resultsmentioning

confidence: 99%

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Prognostic impact of the controlling nutritional status score in patients with hematologic malignancies: A systematic review and meta-analysis

Chen

Fei

et al. 2022

Front. Immunol.

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BackgroundAn increasing number of studies have validated the prognostic significance of the controlling nutritional status (CONUT) score in patients with solid tumors. However, the extent of the correlation between the CONUT score and clinical outcomes of patients with hematologic malignancies is unclear.ObjectiveThis study aimed to investigate the prognostic role of the CONUT score in patients with hematologic malignancies.MethodsAll relevant articles published up to November 15, 2021, were identified by systematically searching PubMed, Embase, Web of Science, and Cochrane Library. Pooled hazard ratios (HRs) and 95% confidence intervals were used to quantitatively analyze the association between the CONUT scores and clinical outcomes of patients with hematologic malignancies. Subgroup and sensitivity analyses were performed. Funnel plots as well as Begg’s and Egger’s tests were used to assess publication bias.ResultsSix studies with 1811 patients were included in the meta-analysis. The results showed that a high CONUT score was associated with worse overall survival (OS) (HR=1.34, 95%CI 1.14-1.59, P < 0.001) and progression-free survival (PFS) (HR=1.20, 95%CI 1.10-1.32, P < 0.001).ConclusionsThe CONUT score is an independent prognostic factor in patients with hematologic malignancies.Systematic review registrationhttp://www.crd.york.ac.uk/prospero/, identifier CRD42021292621.

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Section: Resultsmentioning

confidence: 99%

“…ÇAĞLIYAN A et al. reported that a high CONUT score group was correlated to a worse PFS in patients with DLBCL after univariate analysis ( 18 ). Multivariate analysis also showed that the CONUT score was an independent prognostic factor for PFS.…”

Section: Resultsmentioning

confidence: 99%

Prognostic impact of the controlling nutritional status score in patients with hematologic malignancies: A systematic review and meta-analysis

Chen

Fei

et al. 2022

Front. Immunol.

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“…It can comprehensively reflect the nutritional status of patients by assessing their Alb, TC, LYM, and other aspects, such as protein reserves, calorie consumption, and immune defense status ( 12 , 13 ). The CONUT score can be used to comprehensively assess the nutritional status of patients with non-HIV-infected lymphoma and can be a sensitive predictor of prognosis in patients with lymphoma ( 14 , 15 ). As the most commonly used clinical index in the CONUT score to evaluate the nutritional status of the patient’s body functions, Alb is reduced in patients with lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of nutritional status in patients with human immunodeficiency virus infection-related lymphoma

Liu

Hu²,

Lv³

et al. 2022

Front. Nutr.

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ObjectiveTo investigate the predictive value of nutritional status on the prognosis of patients with human immunodeficiency virus (HIV) infection-related lymphoma.Materials and methodsA total of 149 patients with HIV infection-related lymphoma who were admitted to our hospital from August 2012 to May 2022 were selected as research subjects. Based on the patient prognosis, they were divided into a poor prognosis group (n = 30) and a good prognosis group (n = 119). General data from patients in both groups were collected, and the nutritional status of the patients was evaluated using the Controlling Nutritional Status (CONUT) score. Factors affecting the prognosis of HIV infection-related lymphoma were analyzed using univariate and multivariate analyses, and a prediction model was developed based on the analyzed factors. The receiver operating characteristic (ROC) curve was used to analyze the prediction model of the CONUT score alone and included the CONUT score in the prognosis of patients with HIV infection-related lymphoma. The predictive value of the data was assessed, and a survival curve was drawn to compare the survival of patients with different nutritional statuses.ResultsThere were significant differences in age, B symptoms, treatment conditions, International Prognostic Index (IPI), pathological stage, Eastern Collaborative Tumor Group physical status score (ECOG PS), CD4+ cell count, β2 microglobulin, and lactate dehydrogenase (LDH) between the poor prognosis group and the good prognosis group (p < 0.05). The CONUT score of the poor prognosis group was higher than that of the good prognosis group, and the difference was statistically significant (p < 0.05). A univariate analysis demonstrated that the age, B symptoms, treatment status, IPI, pathological stage, ECOG PS, CD4+ cell count, β2 microglobulin, LDH, and CONUT score were prognostic factors for patients with HIV infection-related lymphoma (p < 0.05). The results of a multivariate regression analysis demonstrated that the age, B symptoms, treatment status, IPI, pathological stage, ECOG PS, and CONUT score were independent risk factors for the prognosis of patients with HIV infection-related lymphoma (p < 0.05). The prediction model was constructed according to the multivariate Cox regression analysis results. The model formula was as follows: Logit(p) = −10.687 + 1.728 × age + 1.713 × B symptoms + 1.682 × treatment status + 1.810 × IPI + 1.643 × pathological stage + 1.584 × ECOG PS + 1.779 × CONUT score. The ROC curve was used to analyze the predictive value of the CONUT score alone and the predictive model including the CONUT score on the prognosis of patients with HIV infection-related lymphoma. The predictive value of the prognosis of patients with tumors was higher (p < 0.05). According to the results of the ROC curve analysis, the patients were divided into a high CONUT group (CONUT > 6.00 points, n = 31) and a low CONUT group (CONUT ≤ 6.00 points, n = 118) based on the Optimum threshold of the CONUT score. The survival curve showed that the survival rate of the high CONUT group was lower than that of the low CONUT group (p < 0.05).ConclusionThe poor prognosis of HIV infection-related lymphoma is related to nutritional status, which is an independent risk factor affecting the prognosis of patients and can be used as a practical indicator to predict the prognosis of patients.

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“…The CONUT score has been proven not only to correlate with malnutrition grade [ 11 ] but also to have a high predictive value concerning clinical outcomes and morbidity. For example, in patients with cancer, a higher CONUT score predicts a lower overall survival, a lower progress/recurrence-free survival, and a lower cancer-specific survival after surgery [ 15 , 16 ], and a similar predictive value has also been observed for non-solid tumors and other hematologic disorders [ 17 , 18 , 19 ]. However, the CONUT score has also been investigated as a predictor of morbidity or mortality in various conditions other than malignancies, for example, in patients undergoing liver transplant [ 20 ] or heart bypass surgery [ 21 ], in patients with acute heart failure [ 22 ], or in patients with pulmonary embolism [ 23 ].…”

Section: Introductionmentioning

confidence: 95%

COntrolling NUTritional Status (CONUT) as Predictive Score of Hospital Length of Stay (LOS) and Mortality: A Prospective Cohort Study in an Internal Medicine and Gastroenterology Unit in Italy

et al. 2023

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Background: Hospital malnutrition affects nearly 30% of patients in medical wards and correlates with worse outcomes. An early assessment is necessary to stratify the risk of short-term outcomes and mortality. The predictive role of COntrolling NUTritional status (CONUT) score in this context has not yet been elucidated in Western countries. We aimed to test CONUT at admission as a predictive score of hospital outcomes, in an Internal Medicine and Gastroenterology Department of an Italian Tertiary Care University hospital. Methods: We prospectively enrolled patients admitted to our center, stratifying them into the four CONUT classes (normal = 0–1; mild = 2–4; moderate = 5–8; severe = 9–12 points) according to serum albumin (g/dL), total lymphocyte count (/mm3), and total cholesterol (mg/dL); the primary outcome measure was length of stay (LOS) and the secondary one was in-hospital mortality. Results: Out of a total of 203 patients enrolled, 44 (21.7%) patients had a normal status (0–1), 66 (32.5%) had a mild impairment (2–4), 68 (33.5%) had a moderate impairment (5–8), and 25 (12.3%) a severe impairment (9–12). The mean LOS was 8.24 ± 5.75 days; nine patients died. A moderate-severe CONUT correlated with a higher LOS at the univariate [HR 1.86 (95% CI 13.9–3.47); p < 0.0001] and multivariate analysis [HR 1.52 (95% CI 1.10–2.09); p = 0.01]. The CONUT score was also a predictor of mortality, with an AUC of 0.831 (95% CI 0.680–0.982) and with an optimal cut-off at 8.5 points. Nutritional supplementation within 48 h from admission correlated with lower mortality [OR 0.12 (95% CI 0.02–0.56) p = 0.006]. Conclusions: CONUT is a reliable and simple predictor of LOS and in-hospital mortality in medical wards.

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Is CONUT score a prognostic index in patients with diffuse large cell lymphoma?

Cited by 11 publications

References 15 publications

Prognostic impact of the controlling nutritional status score in patients with hematologic malignancies: A systematic review and meta-analysis

Prognostic impact of the controlling nutritional status score in patients with hematologic malignancies: A systematic review and meta-analysis

Prognostic value of nutritional status in patients with human immunodeficiency virus infection-related lymphoma

COntrolling NUTritional Status (CONUT) as Predictive Score of Hospital Length of Stay (LOS) and Mortality: A Prospective Cohort Study in an Internal Medicine and Gastroenterology Unit in Italy

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