Is cryosurgery less effective that conservative regimens in the treatment of actinic keratoses?

Zouboulis, C. C.

doi:10.1111/jdv.13294

Cited by 10 publications

(3 citation statements)

References 30 publications

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“…Cryosurgery is a nonspecific treatment option that involves liquid nitrogen to disrupt and separate the epidermis from the dermis, thereby destroying both atypical and normal cells. It is used widely against a small AK or a low number of AKs in a patient (Zouboulis, 2016). Cryosurgery has been the treatment of choice for focal lesions, and the British Association of Dermatologists suggests that it could be used for hypertrophic lesions (Bourke, Coulson, & English, 2009 Stockfleth et al, 2012;Stockfleth et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Relative efficacy of 5‐fluorouracil compared with other treatments among patients with actinic keratosis: A network meta‐analysis

Tang

Cai

et al. 2019

Dermatologic Therapy

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Objective The purpose of this study was to compare the efficacy of 5‐fluorouracil (5‐FU) with that of other treatments of actinic keratosis (AK). Methods A systematic literature review of five databases (including Medline and EMBASE) was first performed to identify randomized controlled trials (RCTs). A network meta‐analysis (NMA) based on a random‐effects Bayesian model was then performed on the outcomes for patients with total clearance and lesions reduced from baseline. Five treatments (viz., 0.5% 5‐FU with 10% salicylic acid [5‐FU/SA], 5% 5‐FU cream, 3% diclofenac sodium, cryosurgery, and vehicle) were evaluated. Results A total of 11 studies involving 2,256 patients with AK were included in this NMA. The overall risk of bias among the included studies was low. All treatments were significantly better than the vehicle both for patients with total clearance and for lesions reduced from baseline. Among patients with total clearance, 5% 5‐FU cream (56.8%) and 5‐FU/SA (35.7%) were likely to be more effective than the other treatments, whereas 5% 5‐FU cream (98.6%) was likely the most effective in the group of lesions reduced from baseline. Conclusion 5‐FU, diclofenac sodium, and cryosurgery are all useful for AK treatment, with 5‐FU being the most effective.

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Section: Discussionmentioning

confidence: 99%

Relative efficacy of 5‐fluorouracil compared with other treatments among patients with actinic keratosis: A network meta‐analysis

Tang

Cai

et al. 2019

Dermatologic Therapy

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“…There was no clear consensus on the cryotherapy method of AK treatment all over the world. Numerous variables can influence the success of cryotherapy: the skill and experience of the physician, freezing time, freezing depth, the pressure of the liquid nitrogen set, the size of the orifice on the device, the distance between the lesion, the number of sessions, size, and the presence of hyperkeratotic lesions [12][13][14]. To get a point of view, Zouboulis published the meta-analysis via 26 studies which compared the regional regimens; they declared that the response rate depends on the clinicians' technique, freezing time, and extended area [13].…”

Section: Actinic Keratosismentioning

confidence: 99%

“…Actually in routine clinical practices, two cycles were applied to BCC lesions. Additionally, thaw time is approximately three times longer than freezing time to share out the lesion [13]. According to oncology guidelines, two freeze-thaw cycles with a tissue temperature of −50°C are recommended [49].…”

Section: Basal Cell Carcinomamentioning

confidence: 99%

Cryotherapy for Common Premalignant and Malignant Skin Disorders

Akarsu¹,

Kamberoglu²

2018

Dermatologic Surgery and Procedures

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Cryotherapy, also known as cryosurgery or cryoablation, is a common dermatological treatment that is an expanded area from benign to malignant lesions. The system has been designed as a localized freezing cold that causes the destruction of cell integrity. The treatment has been also used for all ages, which is not required to have a condition of wellness. It is convenient, fast, and easy to apply in clinics, and there is no need for anesthesia. Additionally, multiple lesions are also cured in the same sessions. After the treatment, recovery period has not taken much longer and also has simple adverse effects, which are tolerable. Lastly, cryotherapy has gained excellent cosmetic results. It is highly effective for actinic keratosis and is the treatment of choice for most old patients who show poor cooperation and recurrent multiple lesions. Additionally, due to increasing premalignant lesions all over the world associated with increasing age, it is a considerable choice for lentigo maligna and Bowen's disease. In non-melanoma skin cancers, it is also the most important option in patients who do not undergo surgery and when other options are not appropriate. In this chapter, the use of cryotherapy for premalignant and malignant cutaneous disorders has been mainly focused.

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Dermatologische Therapie mit Kälte, Wärme oder elektromagnetischen Strahlen

Zouboulis

2018

Braun-Falco’s Dermatologie, Venerologie Und Allergologie

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Is cryosurgery less effective that conservative regimens in the treatment of actinic keratoses?

Cited by 10 publications

References 30 publications

Relative efficacy of 5‐fluorouracil compared with other treatments among patients with actinic keratosis: A network meta‐analysis

Relative efficacy of 5‐fluorouracil compared with other treatments among patients with actinic keratosis: A network meta‐analysis

Cryotherapy for Common Premalignant and Malignant Skin Disorders

Dermatologische Therapie mit Kälte, Wärme oder elektromagnetischen Strahlen

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