Is Curcumine Useful in the Treatment and Prevention of the Tendinopathy and Myotendinous Junction Injury? A Scoping Review

Abstract

Physical activity in general and sports in particular, is a mechanism that produces stress and generates great force in the tendon and in the muscle-tendon unit, which increases the risk of injury (tendinopathies). Eccentric and repetitive contraction of the muscle precipitates persistent microtraumatism in the tendon unit. In the development of tendinopathies, the cellular process includes inflammation, apoptosis, vascular, and neuronal changes. Currently, treatments with oral supplements are frequently used. Curcumin seems to preserve, and even repair, damaged tendons. In this systematic review, we focus more especially on the benefits of curcumin. The biological actions of curcumin are diverse, but act around three systems: (a) inflammatory, (b) nuclear factor B (NF-κB) related apoptosis pathways, and (c) oxidative stress systems. A bibliographic search is conducted under the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) as a basis for reporting reliable systematic reviews to perform a Scoping review. After analysing the manuscripts, we can conclude that curcumin is a product that demonstrates a significant biological antialgic, anti-inflammatory, and antioxidant power. Therefore, supplementation has a positive effect on the inflammatory and regenerative response in tendinopathies. In addition, curcumin decreases and modulates the cell infiltration, activation, and maturation of leukocytes, as well as the production of pro-inflammatory mediators at the site of inflammation.

Effects of Curcuma longa (turmeric) and curcumin on the premenstrual syndrome and dysmenorrhea: A systematic review

“…Additionally, curcumin has been found to suppress the expression of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin (IL)-6, which may play critical roles in the initiation and propagation of inflammation. 43 Curcumin potentially regulates Mitogen-activated protein kinases (MAPK), Activator Protein 1 (AP-1), the Janus kinase/Signal transducer and activator of transcription (JAK/STAT), and other signaling pathways. It prevents the production of inflammatory mediators.…”

“…44 So, they play a crucial role in promoting inflammation and sensitizing pain receptors; thus, by inhibiting their activity, curcumin helps reduce pain sensations. 43…”

“…44 So, they play a crucial role in promoting inflammation and sensitizing pain receptors; thus, by inhibiting their activity, curcumin helps reduce pain sensations. 43 Additionally, curcumin has been found to modulate the transmission of pain signals by affecting neurotransmitters such as serotonin, dopamine, and glutamate. These neurotransmitters play a crucial role in transmitting pain-related signals and perceiving pain.…”

Metabolic Syndrome and Tendon Disease: A Comprehensive Review

“…Diabetes, Metabolic Syndrome and Obesity 2024:17 1602 agonist of CFTR, has been shown to benefit tendon repair, further confirming the significant role of CFTR in tendon repair. [82][83][84] Studies have also linked CFTR to DM. 85,86 One confirmed that high glucose levels inhibited TDSC proliferation and differentiation through the let-7b-5p/CFTR pathway, contributing to poor tendon healing in patients with DM (Figure 2A).…”