Is Cytology Useful in the Diagnostic Workup of Male Breast Lesions?

Wauters, C. A. P.; Kooistra, Bauke W; Heijden, Ineke M de Kievit-van der; Strobbe, Luc J. A.

doi:10.1159/000325032

Cited by 24 publications

(3 citation statements)

References 10 publications

(20 reference statements)

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“…Male patients comprise only a minority of FNA clinic visits, ranging from 1.7 to 5.8% of the total patients, as reported in a few large studies of breast FNA biopsies [16, 18, 19, 27, 28]. In this 10-year, single-institution study, 74 (3.7%) out of 2,008 breast FNA biopsies were from male patients.…”

Section: Discussionmentioning

confidence: 65%

Diagnostic Value of Fine-Needle Aspiration in Male Breast Lesions

et al. 2019

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Objective: Differentiation between gynecomastia, a common cause of male breast enlargement, and breast cancer is crucial for appropriate management. Fine-needle aspiration biopsy has been shown to be sensitive and specific in assessing female breast lesions, comparable to core needle biopsy. Few such studies have been conducted in men. We assessed its diagnostic value in a male patient cohort. Study Design: Men who underwent fine-needle aspiration (FNA) for palpable breast lesions at Massachusetts General Hospital from January 2007 to December 2016 were evaluated. Clinical data, radiographic findings, and cytologic diagnoses of 74 breast FNA from 71 men were reviewed. Breast aspirates were classified as nondiagnostic, benign, atypical, suspicious for malignancy, or malignant. Histology was obtained in 37 cases, and clinical and radiological data were used as follow-up in 37 patients. Results: Most FNA biopsies (73%) were performed by cytopathologists, and 93.2% of the breast FNA in men were adequate; 58% showed benign processes, mostly gynecomastia (n = 22), and 28.4% (n = 21) were malignant, most often ductal carcinoma. No false-positive cytologies were obtained, and there was 1 false-negative cytology. In our study, FNA of palpable male breast lesions was 95.8% sensitive and 100% specific. Conclusions: FNA allows sensitive, specific, and safe evaluation and diagnosis of palpable male breast lesions.

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Section: Discussionmentioning

confidence: 65%

Diagnostic Value of Fine-Needle Aspiration in Male Breast Lesions

et al. 2019

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“…Two cases of infiltrating duct carcinoma and two cases that were first considered to be malignancies but were later revealed to be duct malignancies on histological examination were both found in the current investigation. 10.5% of the cases in our analysis had infiltrating duct carcinoma, which is close to the findings of Wauters et [29,30,24]. Benign lesions have a lesser chance of being biopsied.…”

Section: Discussionsupporting

confidence: 90%

Cytological Evaluation of Male Breast Lesions: Retrospective Analysis in Northern State of India.

Gupta,

Sharma,

Thapa

et al.

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Background:Symptoms of breast sickness commonly include breast discomfort, nipple discharge, and palpable breast lumps. Breast cytology, which involves fine-needle aspiration, nipple discharge smear, and touch preparation, may accurately assess breast specimens. This study's goals are to categorize the different cancers of the breast that breast cytology can diagnose and to assess the clinical sufficiency of narrative reporting of breast cytology results. Methods:The medical files of 390 patients who visited the general surgery clinics at the Rajendra Prasad Medical College, Tanda within five years underwent retrospective analysis. Results:Neoplastic breast lesions accounted up 75.9% of the overall number of breast lesions, however, all diagnostic breast lesions (n = 94) were non-neoplastic. The ratio of benign to malignant lesions was 2.6:1, with 72.3% of benign and 27.7% of malignant lesions among the neoplastic lesions (n = 214). Gynecomastia (n = 33) and fibroadenoma (n = 136) were the most frequently diagnosed breast lesions in both men and women. Conclusions:Both malignant and non-cancerous breast lesions were correctly detected by breast cytology. By comparing our findings with previous observations made by other authors, the conclusion that was drawn was that women were more likely than men to develop neoplastic breast lesions, whereas men were more likely to develop non-neoplastic lesions. Recommendation:This hospital is advised to implement a synoptic reporting format that includes the diagnostic categories (C1 to C5) of the United Kingdom's National Health Service Breast Screening Programme to resolve the issues related to narrative reporting of breast cytology results.

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“…It is responsible for <0.1% of men dying from any malignancy (24). In earlier studies on male breast pathologies, its malignant etiology was recorded in 2.5%-28.4% of the cases (1,4,7,18,20,25). Risk factors include older age, family history of breast cancer, radiation exposure, cryptorchidism, testicular trauma, Klinefelter syndrome, liver disease, and BRCA2 gene mutation.…”

Section: Discussionmentioning

confidence: 99%

Cytological Evaluation of Pathological Male Breast Lesions

Mondal¹,

Mandal²

2021

EJBH

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Morphologically, the male breasts, like its female counter organs, consist of glandular and adipose tissues. However, in men, glandular units are composed of ducts only, which are typically circumscribed underneath the nipple-areolar complex (1). Pathological lesions in male breasts are not common. Gynecomastia is the most common lesion in men. Its prevalence varies from 32% to 65% with respect to age groups. In postmortem male breast specimens, gynecomastia has been reported in 45%-50% of the cases (2). Similarly, carcinomas rarely occur in male breasts. It accounts for 1% of all breast cancer cases arising in both sexes, and approximately 1% of all malignancies occur in men. Clinically, it resembles gynecomastia as well as any other benign pathological lesions associated with male breast enlargement. Therefore, urgent discrimination of these two contrasting pathological entities is necessary (3). For this purpose, core needle biopsy and the recently amended vacuum-assisted breast biopsy are the most useful diagnostic method. However, as the most common male breast pathology, gynecomastia is best cured conservatively; it is therefore unreasonable to consider biopsy as the primary diagnostic intervention. On the contrary, fine needle aspiration cytology (FNAC) provides prompt and precise diagnoses economically and conveniently (4, 5). This study aimed to cytologically evaluate various pathological lesions that affect the male breasts and to validate the diagnostic accuracy of FNAC against the histopathology wherever practicable.

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Is Cytology Useful in the Diagnostic Workup of Male Breast Lesions?

Cited by 24 publications

References 10 publications

Diagnostic Value of Fine-Needle Aspiration in Male Breast Lesions

Diagnostic Value of Fine-Needle Aspiration in Male Breast Lesions

Cytological Evaluation of Male Breast Lesions: Retrospective Analysis in Northern State of India.

Cytological Evaluation of Pathological Male Breast Lesions

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