Is Decidua Affected in Gestational Hypertension?: Indication by Elevated Pp14 Levels

Iino, Koichi; Julkunen, Mervi; Sjöberg, Jari; Seppälä, Markku

doi:10.3109/00016348609157362

Cited by 13 publications

(9 citation statements)

References 21 publications

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“…Interestingly, some women with preeclampsia show an increased glycodelin concentration during advancing pregnancy, compared with the normal pattern of decreasing values (31). In a study on gestational hypertension, the serum glycodelin levels were significantly higher than in normal pregnancy, being above the normal median in 80% of cases and above the normal 90th percentile in 38% of cases (191), but again, not all studies have confirmed this (192).…”

Section: Late Pregnancy Disordersmentioning

confidence: 81%

Glycodelin: A Major Lipocalin Protein of the Reproductive Axis with Diverse Actions in Cell Recognition and Differentiation

et al. 2002

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Glycodelin is a glycoprotein that belongs to the lipocalin superfamily. Depending on glycosylation, glycodelin appears in various isoforms. In the uterus, glycodelin-A is the major progesterone-regulated glycoprotein secreted into uterine luminal cavity by secretory/decidualized endometrial glands. The other tissues expressing glycodelin include fallopian tubes, ovary, breast, seminal vesicle, bone marrow, and eccrine glands. Glycodelin-A potently and dose-dependently inhibits human sperm-egg binding, whereas differently glycosylated glycodelin-S from seminal plasma has no such effect. Absence of contraceptive glycodelin-A in the uterus during periovulatory midcycle is consistent with an open "fertile window." Glycodelin induced by local or systemic administration of progestogens may potentially reduce the fertilizing capacity of sperm in any phase of the menstrual cycle. Glycodelin also has immunosuppressive activity. Its high concentration at the fetomaternal interface may contribute to protection of the embryonic semiallograft. Besides being an epithelial differentiation marker, glycodelin appears to play a role in glandular morphogenesis, as transfection of glycodelin cDNA into a glycodelin-negative breast cancer cells resulted in formation of gland-like structures, restricted proliferation, and induction of other epithelial markers. These various properties, as well as the chemistry, biology, and clinical aspects of glycodelin, continue to be areas of active investigation reviewed in this communication.

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Section: Late Pregnancy Disordersmentioning

confidence: 81%

Glycodelin: A Major Lipocalin Protein of the Reproductive Axis with Diverse Actions in Cell Recognition and Differentiation

et al. 2002

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“…Biochemical tests of fetoplacental well-being have been applied in this condition (6), sometimes with dramatic clinical significance (20,29). Increased concentrations of PP12 and PP14 have been described previously in pre-eclampsia (12,13,32) but no details were given regarding the severity of the disease-merely the presence or absence of proteinuria. In order to investigate further how preeclampsia affects the decidua, in addition to its known effect on the placenta, we have examined PP12 and PP14 levels in different grades of pre-eclampsia.…”

mentioning

confidence: 99%

Placental Proteins 12 And 14 In Pre‐Eclampsia

Howell

Economides

Teisner

et al. 1989

Acta Obstet Gynecol Scand

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The concentrations of circulating placental protein 12 (PP12) and placental protein 14 (PP14) were measured in 41 patients with pre-eclampsia and in 17 control subjects. The levels of PP12 were significantly elevated in patients with severe preeclampsia, whereas PP14 levels were unaffected. There was a negative correlation between the levels of both PP12 and PP14 and birthweight. PP12 and PP14 appear therefore to have different control mechanisms and, possibly, different cellular origins within the decidua.

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“…In gestational hypertension, the values were higher than normal. The presence or absence of proteinuria did not affect these results [10]. In contrast, Howell et al [8] demonstrated a slight reduction in the median values of PP14 in pregnancies complicated by hypertension.…”

Section: Discussionmentioning

confidence: 90%

“…Iino et al [10] investigated serum concentration of placental protein 14 (PP14), which is the former name for glycodelin, in 129 healthy pregnant women and 40 women with gestational hypertension either with or without proteinuria at similar weeks. In normal pregnancy, maternal serum PP14 levels decreased towards term.…”

Section: Discussionmentioning

confidence: 99%

Expression of glycodelin A in decidual tissue of preeclamptic, HELLP and intrauterine growth-restricted pregnancies

et al. 2005

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During pregnancy, the placenta produces a variety of proteins that are responsible for the establishment of the foeto-maternal tolerance and circulation. The aim of this study was to investigate the expression of glycodelin A (formerly named PP14) in decidual tissue of placentas with intrauterine growth restriction (IUGR), preeclamptic patients, hemolysis, elevated liver, low-platelet (HELLP) patients and normal decidual tissue. Slides of paraffin-embedded decidual tissue of patients with IUGR, preeclamptic patients, HELLP patients and normal-term placentas were incubated with either polyclonal or monoclonal antibodies against glycodelin A. Staining reaction was performed with the ABC reagent. Intensity of immunohistochemical reaction on the slides was analysed using a semi-quantitative score. In addition, expression of glycodelin mRNA was analysed by in situ hybridisation. Expression of glycodelin A was significantly reduced in decidual cells of placentas with IUGR and HELLP, as investigated with both monoclonal and polyclonal antibodies and in situ hybridisation. However, preeclamptic decidual tissue showed no significantly different expression of intensity of glycodelin mRNA compared with normal placental tissue controls. A reduced expression of glycodelin A by decidual cells seems to be related to IUGR and HELLP. Therefore, glycodelin A might play an important role in the pathogeneses of these diseases.

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Is Decidua Affected in Gestational Hypertension?: Indication by Elevated Pp14 Levels

Cited by 13 publications

References 21 publications

Glycodelin: A Major Lipocalin Protein of the Reproductive Axis with Diverse Actions in Cell Recognition and Differentiation

Glycodelin: A Major Lipocalin Protein of the Reproductive Axis with Diverse Actions in Cell Recognition and Differentiation

Placental Proteins 12 And 14 In Pre‐Eclampsia

Expression of glycodelin A in decidual tissue of preeclamptic, HELLP and intrauterine growth-restricted pregnancies

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