Is dehydration test using isosorbide useful in Meniere’s disease?

Lee, Jong Dae; Kim, Hyun Ji; Jung, Jinsei; Kim, Sung Huhn; Kim, Bo Gyung; Kim, Kyu-Sung

doi:10.1080/00016489.2016.1195917

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…An oral osmotic diuretic, isosorbide solution, is an alternative. It is well tolerated for most of patients with MD with only a few experiencing headaches or nausea after medication [11]. We hypothesize that changing the type of diuretics is a valid option if complications occur after initial diuretic administration.…”

Section: Discussionmentioning

confidence: 99%

Optimal First-Line Therapy for Acute Low-Tone Sensorineural Hearing Loss

et al. 2021

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Background and Objectives: We aimed to analyze treatment outcomes following different initial management approaches and confirm treatment regimens for acute low-tone sensorineural hearing loss (ALHL) that would yield the best results. Subjects and Methods: We retrospectively analyzed the medical records of 106 patients with ALHL who visited a university hospital's otology clinic from March 2013 to June 2019. Pure-tone averages at the initial visit and at 2 and 4 weeks after the initial visit were evaluated. Results: Forty-nine patients were enrolled in this study; of them, 41 (83.7%) exhibited complete recovery (CR) at 2 weeks and 43 (87.8%) exhibited CR at 1 month after the initial visit. Regression analysis revealed that CR at 2 weeks after the initial visit was associated with diuretic use [Exp(B): 10.309, 95% confidence interval (CI): 1.007-100]. An initial daily low-dose steroid use was marginally significant [Exp(B): 1.042, 95% CI: 0.997-1.092; p=0.066]. Isolated diuretic use [Exp(B): 25.641, 95% CI: 1.121-90.909; p=0.039] was an independent, good prognostic factor at 1 month after the initial visit. However, other treatment regimens did not affect the final results. Conclusions: A combination of initial daily administration of ≤30 mg prednisolone plus diuretics was sufficient as the first-line treatment for ALHL. High-dose steroids and salvage intratympanic steroid injections can be applied as a second choice; however, the predicted outcome would not be good in that case.

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Section: Discussionmentioning

confidence: 99%

Optimal First-Line Therapy for Acute Low-Tone Sensorineural Hearing Loss

et al. 2021

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“…In particular, isosorbide(ISB) has been widely used to improve the endolymphatic hydrops (Kitahara et al, 1982;Stahle, 1984;Kakigi et al, 1995;Lee et al, 2016).Since ISB is poorly metabolized, the mega dose of concentrated ISB makes water move from the tissue and into the blood. ISB acts on the stria vascularis in the ear, or on the endolymphatic sac and duct, and decreases endolymphatic pressure.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Physicochemical Propertiesof Isosorbide Gel Composed of Xanthan Gum, Locust Bean Gum and Agar for Improving the Patient�s Adherence

Kawano¹,

Kiuchi²,

Haraguchi³

et al. 2017

IJMP

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Isosorbide (ISB) has been widely used as a treatment for improving the endolymphatic hydrops of Meniere's disease. In general, ISB is used as a 70%(w/w) solution in medical treatments; however, ISB has a bitter taste,which reduces patient compliance. In recent years, jelly or gel formulations have been developed as "patient-friendly" and/or "patient-convenient" formulation. In this study, we attempted to develop various gel formulations of ISB to improve patient'sadherence. We used xanthan gum (XG), locust bean gum (LBG), and agar as gelling agents. The hardness of the gels was greatest with an XG:LBG mixture ratio of 1:1. When ISB was added to the gels, their strength decreased but still showed suitable values.Wealso investigated methods to mask the bitterness of ISB.Gel formulations reduced the bitterness of ISB, and the addition of stevia, to the ISB gels improved bitterness. Collectively, these findings indicate that these ISB gels may be useful formulations for improving the patient's adherence.

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Comparison of the outcomes of treatment with an oral diuretics with steroid and steroid only for acute low-tone hearing loss: a prospective randomized controlled trial

Hong,

Choi,

Park

et al. 2024

Res Vestib Sci

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Objectives: This study aimed to compare the efficacy of a combined steroid and diuretic (isosorbide) treatment with that of steroid-only treatment in patients with acute low-tone sensorineural hearing loss (ALHL). Methods: A total of 34 patients with ALHL were recruited between January 2018 and December 2019 and randomized into two groups: a steroid-with-diuretic (isosorbide) group and a steroid-only group. The steroid-with-diuretic group received oral methylprednisolone for 10 days and isosorbide for 14 days, while the steroid-only group received methylprednisolone for 10 days. Hearing outcomes were measured using pure-tone audiometry at 8 weeks posttreatment. The outcomes were the absolute hearing gain at low frequencies (125, 250, and 500 Hz) and the recovery rate, which was classified into complete, partial, unchanged, progressive, and fluctuating.Results: Of 34 patients, 30 (15 in each group) were analyzed. No significant differences were observed in baseline characteristics between the groups. The steroid-with-diuretic group showed higher absolute hearing gains at all three low frequencies than the steroid-only group, but the differences were not statistically significant complete recovery was observed in 13 patients in each group, with partial recovery in two patients in the steroid-with-diuretic group and unchanged outcomes in two patients in the steroid-only group. No patient exhibited disease progression.Conclusions: Although combined steroid and diuretic therapy yielded better hearing outcomes than steroid-only therapy, the differences were not statistically significant. Further studies with larger sample sizes and extended follow-up periods are necessary to confirm these findings.

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Is dehydration test using isosorbide useful in Meniere’s disease?

Cited by 4 publications

References 16 publications

Optimal First-Line Therapy for Acute Low-Tone Sensorineural Hearing Loss

Optimal First-Line Therapy for Acute Low-Tone Sensorineural Hearing Loss

Preparation and Evaluation of Physicochemical Propertiesof Isosorbide Gel Composed of Xanthan Gum, Locust Bean Gum and Agar for Improving the Patient�s Adherence

Comparison of the outcomes of treatment with an oral diuretics with steroid and steroid only for acute low-tone hearing loss: a prospective randomized controlled trial

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