Is “delayed” hyperbaric therapy effective for “delayed” encephalopathy after carbon monoxide intoxication?

Pappalardo, Irene; L, Celli; Arena, Luciano; Testa, Lucia; Giovanniello, Andrea; Cava, Mariangela; Colla, L; Ghiazza, G; Morelli, Nicola; Rota, Eugenia

doi:10.1016/j.ensci.2019.100219

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…These patients developed DNS weeks to months after acute CO poisoning, and all presented to the hospital with severe cognitive and neurologic deficits that cost them independence in daily life activities. They underwent 10–40 sessions of HBOT, whereby periodic assessments by neuropsychologic test and image study were done; in some of the patients it was found that the lesions over the globus pallidus and white matter had disappeared after HBOT, which was also consistent with their symptoms 16 , 25 , 34 , 35 .…”

Section: Discussionmentioning

confidence: 93%

“…However, Carstairs et al conducted a study in a murine model focusing on the number of HBOT sessions after CO poisoning, and found that there was no difference between groups treated with either one or three HBOT sessions 40 . Only a few literature reports have focused on how many sessions of HBOT are appropriate at the acute CO poisoning stage to prevent DNS, and a range from one session to 40 or more sessions have been reported in small sample-size prospective studies or case reports 15 , 16 , 25 , 34 . Further larger scale studies are warranted to clarify the optimal treatment sessions at the acute CO poisoning stage for DNS prevention.…”

Section: Discussionmentioning

confidence: 99%

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Real-world effectiveness of hyperbaric oxygen therapy for delayed neuropsychiatric sequelae after carbon monoxide poisoning

Liao

Shao

Yang

et al. 2021

Sci Rep

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To assess real-world effectiveness of hyperbaric oxygen therapy (HBOT) on delayed neuropsychiatric sequelae (DNS) after carbon monoxide (CO) poisoning we conducted a retrospective review of patients with CO poisoning admitted to Linkou Chang-Gung Memorial Hospital, Taiwan’s largest medical center, during 2009–2015. We included patients developing DNS after CO poisoning and compared improvements in neuropsychiatric function, with and without HBOT, after 12 months post-DNS to understand differences in recovery rates. DNS improvement-associated factors were also evaluated. We used receiver operating characteristic (ROC) curve analysis to assess the role of time elapsed between DNS diagnosis and HBOT initiation in predicting DNS improvement. A total of 62 patients developed DNS, of whom 11 recovered while the rest did not. Possible factors predicting DNS improvement included receiving HBOT post-DNS (72.7% vs 25.5%; P = 0.006), and treatment with more than three HBOT sessions during acute stage CO poisoning (81.8% vs 27.5%; P = 0.003). The relevant area under the ROC curve was 0.789 (95% CI 0.603–0.974), and the best cut-off point was 3 days post-DNS diagnosis, with 87.5% sensitivity and 61.5% specificity. Early HBOT in patients who developed DNS after CO poisoning significantly improved their DNS symptoms, with treatment effects sustained for 1 year after DNS diagnosis.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Real-world effectiveness of hyperbaric oxygen therapy for delayed neuropsychiatric sequelae after carbon monoxide poisoning

Liao

Shao

Yang

et al. 2021

Sci Rep

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“…Thus, delayed neurologic sequelae of COP should be well recognized by other clinicians such as neurologists and psychiatrists [13]. Although response to different treatment modalities varies in individuals, patient selection for HBOT should be done carefully [14]. Carbon monoxide poisoning, is not only a life-threatening health problem, but also it may exert deleterious effects on the quality of life of the patient with its delayed sequelae.…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy for Carbon Monoxide Poisoning can Lead a Perfect Result: A Case Report

2021

Canadian Journal of Medicine

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Carbon monoxide poisoning (COP) is a common emergency worldwide, especially in the wintertime. It is known to cause serious morbidities, resulting in high mortality risk. COP is also reported to result in neurological complications for which hyperbaric oxygen therapy is likely to offer some benefits, which certainly makes it one of the potential treatment modalities. Here, Case in the paper is of a 64-year-old female patient with carbon monoxide poisoning. Her neurological symptoms nearly disappeared after the application of hyperbaric oxygen therapy (HBOT) and conventional medical treatment. Our case guides for the key role of HBOT in the treatment process of a 64-year-old female patient with COP. Our clinical experience revealed that hyperbaric oxygen therapy could successfully reverse the symptoms of delayed neurological findings caused by COP, a serious and preventable health problem.

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Early Diagnosis to Prevent Carbon Monoxide Poisoning Complications

Desai,

Shukla

2024

AIM Clinical Cases

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Is “delayed” hyperbaric therapy effective for “delayed” encephalopathy after carbon monoxide intoxication?

Cited by 3 publications

References 9 publications

Real-world effectiveness of hyperbaric oxygen therapy for delayed neuropsychiatric sequelae after carbon monoxide poisoning

Real-world effectiveness of hyperbaric oxygen therapy for delayed neuropsychiatric sequelae after carbon monoxide poisoning

Hyperbaric Oxygen Therapy for Carbon Monoxide Poisoning can Lead a Perfect Result: A Case Report

Early Diagnosis to Prevent Carbon Monoxide Poisoning Complications

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